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The use of complex machine learning models can make systems opaque to users. Machine learning research proposes the use of post-hoc explanations. However, it is unclear if they give users insights into otherwise uninterpretable models. One…

Human-Computer Interaction · Computer Science 2019-05-09 Martin Schuessler , Philipp Weiß

In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques

There has been much progress in data-driven artificial intelligence technology for medical image analysis in the last decades. However, it still remains challenging due to its distinctive complexity of acquiring and annotating image data,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Chao Gou , Tianyu Shen , Wenbo Zheng , Huadan Xue , Hui Yu , Qiang Ji , Zhengyu Jin , Fei-Yue Wang

Nowadays Artificial Intelligence (AI) has become a fundamental component of healthcare applications, both clinical and remote, but the best performing AI systems are often too complex to be self-explaining. Explainable AI (XAI) techniques…

Machine Learning · Computer Science 2022-09-15 Flavio Di Martino , Franca Delmastro

A longstanding challenge surrounding deep learning algorithms is unpacking and understanding how they make their decisions. Explainable Artificial Intelligence (XAI) offers methods to provide explanations of internal functions of algorithms…

Artificial Intelligence · Computer Science 2022-08-16 Amin Nayebi , Sindhu Tipirneni , Brandon Foreman , Chandan K. Reddy , Vignesh Subbian

Background: Despite the current ubiquity of Large Language Models (LLMs) across the medical domain, there is a surprising lack of studies which address their reasoning behaviour. We emphasise the importance of understanding reasoning…

Computation and Language · Computer Science 2025-07-29 Shamus Sim , Tyrone Chen

Model explainability is essential for the creation of trustworthy Machine Learning models in healthcare. An ideal explanation resembles the decision-making process of a domain expert and is expressed using concepts or terminology that is…

Machine Learning · Computer Science 2021-07-14 Sumedha Singla , Stephen Wallace , Sofia Triantafillou , Kayhan Batmanghelich

Machine learning (ML) is increasingly used to support decision-making in the healthcare sector. While ML approaches provide promising results with regard to their classification performance, most share a central limitation, namely their…

In recent years, machine learning (ML) has become a key enabling technology for the sciences and industry. Especially through improvements in methodology, the availability of large databases and increased computational power, today's ML…

Artificial Intelligence · Computer Science 2019-09-27 Wojciech Samek , Klaus-Robert Müller

In recent years, artificial intelligence (AI) systems have come to the forefront. These systems, mostly based on Deep learning (DL), achieve excellent results in areas such as image processing, natural language processing, or speech…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Frantisek Sefcik , Wanda Benesova

Explainability is motivated by the lack of transparency of black-box Machine Learning approaches, which do not foster trust and acceptance of Machine Learning algorithms. This also happens in the Predictive Process Monitoring field, where…

Artificial Intelligence · Computer Science 2025-07-25 Williams Rizzi , Marco Comuzzi , Chiara Di Francescomarino , Chiara Ghidini , Suhwan Lee , Fabrizio Maria Maggi , Alexander Nolte

Medical imaging is an invaluable resource in medicine as it enables to peer inside the human body and provides scientists and physicians with a wealth of information indispensable for understanding, modelling, diagnosis, and treatment of…

Image and Video Processing · Electrical Eng. & Systems 2022-08-25 Hanene Ben Yedder , Ben Cardoen , Ghassan Hamarneh

In the ever-evolving field of Artificial Intelligence, a critical challenge has been to decipher the decision-making processes within the so-called "black boxes" in deep learning. Over recent years, a plethora of methods have emerged,…

Artificial Intelligence · Computer Science 2024-02-15 Karam Dawoud , Wojciech Samek , Peter Eisert , Sebastian Lapuschkin , Sebastian Bosse

The deployment of Machine Learning models intraoperatively for tissue characterisation can assist decision making and guide safe tumour resections. For image classification models, pixel attribution methods are popular to infer…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Alfie Roddan , Chi Xu , Serine Ajlouni , Irini Kakaletri , Patra Charalampaki , Stamatia Giannarou

Explanatory interactive learning (XIL) enables users to guide model training in machine learning (ML) by providing feedback on the model's explanations, thereby helping it to focus on features that are relevant to the prediction from the…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Nathanya Satriani , Djordje Slijepčević , Markus Schedl , Matthias Zeppelzauer

Medical imaging is a cornerstone of therapy and diagnosis in modern medicine. However, the choice of imaging modality for a particular theranostic task typically involves trade-offs between the feasibility of using a particular modality…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Mayur Mallya , Ghassan Hamarneh

The rapid evolution of deep learning has significantly advanced the field of medical image analysis. However, despite these achievements, the further enhancement of deep learning models for medical image analysis faces a significant…

Image and Video Processing · Electrical Eng. & Systems 2023-10-11 Suruchi Kumari , Pravendra Singh

Deep learning methods have become very popular for the processing of natural images, and were then successfully adapted to the neuroimaging field. As these methods are non-transparent, interpretability methods are needed to validate them…

Computer Vision and Pattern Recognition · Computer Science 2022-04-15 Elina Thibeau-Sutre , Sasha Collin , Ninon Burgos , Olivier Colliot

Although modern machine learning and deep learning methods allow for complex and in-depth data analytics, the predictive models generated by these methods are often highly complex, and lack transparency. Explainable AI (XAI) methods are…

Machine Learning · Computer Science 2021-06-17 Mythreyi Velmurugan , Chun Ouyang , Catarina Moreira , Renuka Sindhgatta

In artificial intelligence (AI), the complexity of many models and processes surpasses human understanding, making it challenging to determine why a specific prediction is made. This lack of transparency is particularly problematic in…

Machine Learning · Statistics 2025-06-30 Alexandra Stadler , Werner G. Müller , Radoslav Harman
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