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In response to the evolving landscape of data storage, researchers have increasingly explored non-traditional platforms, with DNA-based storage emerging as a cutting-edge solution. Our work is motivated by the potential of in-vivo DNA…

Information Theory · Computer Science 2024-01-09 Ohad Elishco

With the availability of hybrid DRAM-NVRAM memory on the memory bus of CPUs, a number of file systems on NVRAM have been designed and implemented. In this paper we present the design and implementation of a file system on NVRAM called…

Operating Systems · Computer Science 2018-11-05 Chandan Kalita , Gautam Barua , Priya Sehgal

In this work, we show that by varying the experimental conditions, the driving amplitude, a dynamic force microscope allows DNA properties to be selectively imaged. The substrate on which the DNA is fixed is a silica surface grafted with…

Biological Physics · Physics 2016-08-16 Laurent Nony , Rodolphe Boisgard , Jean-Pierre Aimé

DNA adsorption on solid or liquid surfaces is a topic of broad fundamental and applied interest. Here we study by x-ray reflectivity the adsorption of monodisperse double-stranded DNA molecules a positively-charged surface, obtained through…

Soft Condensed Matter · Physics 2008-09-29 Carine Douarche , Robert Cortès , Steven J. Roser , Jean-Louis Sikorav , Alan Braslau

Dielectrophoresis can potentially be used as an efficient trapping tool in the fabrication of molecular devices. For nanoscale objects, however, the Brownian motion poses a challenge. We show that the use of carbon nanotube electrodes makes…

Debates about conductivity of DNAs have been recently renewed due to contradictory results of direct measurements by use of electrical contacts to molecules. In several works it was discovered that double-stranded (ds)DNAs are conductors:…

Condensed Matter · Physics 2007-05-23 A. Yu. Kasumov , D. V. Klinov

Reference-guided DNA sequencing and alignment is an important process in computational molecular biology. The amount of DNA data grows very fast, and many new genomes are waiting to be sequenced while millions of private genomes need to be…

The energetic and transport properties of a double-stranded DNA dodecamer encapsulated in hydrophobic carbon nanotubes are probed employing two limiting nanotube diameters, D=4 nm and D=3 nm, corresponding to (51,0) and (40,0) zig-zag…

Biological Physics · Physics 2016-05-06 Fernando J. A. L. Cruz , Juan J. de Pablo , José P. B. Mota

DNA-based storage has emerged as a promising approach to the global data crisis, offering molecular-scale density and millennial-scale stability at low maintenance cost. Over the past decade, substantial progress has been made in storing…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Cihan Ruan , Lebin Zhou , Bingqing Zhao , Rongduo Han , Qiming Yuan , Chenchen Zhu , Linyi Han , Liang Yang , Wei Wang , Wei Jiang , Nam Ling

Dielectrophoretic trapping of six different DNA fragments, sizes varying from the 27 to 8416 bp, has been studied using confocal microscopy. The effect of the DNA length and the size of the constriction between nanoscale fingertip…

To increase the information capacity of DNA storage, composite DNA letters were introduced. We propose a novel channel model for composite DNA in which composite sequences are decomposed into ordered standard non-composite sequences. The…

Information Theory · Computer Science 2025-10-31 Besart Dollma , Ohad Elishco , Eitan Yaakobi

Emerging high-performance storage technologies are opening up the possibility of designing new distributed data acquisition system architectures, in which the live acquisition of data and their processing are decoupled through a storage…

Instrumentation and Detectors · Physics 2020-11-04 Adam Abed Abud , Giovanna Lehmann , Roland Sipos

Emerging DNA storage technologies use composite DNA letters, where information is represented by a probability vector, leading to higher information density and lower synthesis costs. However, it faces the problem of information leakage in…

Information Theory · Computer Science 2025-04-29 Wenkai Zhang , Zhiying Wang

Recent experiments have demonstrated the feasibility of storing digital information in macromolecules such as DNA and protein. However, the DNA storage channel is prone to errors such as deletions, insertions, and substitutions. During the…

Information Theory · Computer Science 2024-10-22 Aryan Abbasian , Mahtab Mirmohseni , Masoumeh Nasiri Kenari

An approach for approximately calculating the number of genes in a genome is presented, which takes into account the average protein length expected for the species. A number of virus, bacterial and eukaryotic genomes are scrutinized.…

Genomics · Quantitative Biology 2015-02-13 N. S. Santos-Magalhaes , H. M. de Oliveira

DNA-based data storage systems face practical challenges due to the high cost of DNA synthesis. A strategy to address the problem entails encoding data via topological modifications of the DNA sugar-phosphate backbone. The DNA Punchcards…

Emerging Technologies · Computer Science 2025-05-07 Jin Sima , Chao Pan , S. Kasra Tabatabaei , Alvaro G. Hernandez , Charles M. Schroeder , Olgica Milenkovic

Effective and reliable data retrieval is critical for the feasibility of DNA storage, and the development of random access efficiency plays a key role in its practicality and reliability. In this paper, we study the Random Access Problem,…

Information Theory · Computer Science 2025-10-10 Anina Gruica , Maria Montanucci , Ferdinando Zullo

The errors occurring in DNA-based storage are correlated in nature, which is a direct consequence of the synthesis and sequencing processes. In this paper, we consider the memory-$k$ nanopore channel model recently introduced by Hamoum et…

Information Theory · Computer Science 2023-03-27 Issam Maarouf , Eirik Rosnes , Alexandre Graell i Amat

In this paper, we consider a concatenated coding based class of DNA storage codes in which the selected molecules are constrained to be taken from an ``inner'' codebook associated with the sequencing channel. This codebook is used in a…

Information Theory · Computer Science 2025-06-19 Yan Hao Ling , Jonathan Scarlett

Codd [Codd 1970] wrote the first paper in which the model of a relational database was proposed. Adleman [Adleman 1994] wrote the first paper in which DNA strands in a test tube were used to solve an instance of the Hamiltonian path…

Neural and Evolutionary Computing · Computer Science 2007-12-13 Weng-Long Chang , Michael , Ho , Minyi Guo