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The healthcare sector has experienced a rapid accumulation of digital data recently, especially in the form of electronic health records (EHRs). EHRs constitute a precious resource that IS researchers could utilize for clinical applications…
Chronic diseases are long-lasting conditions that require lifelong medical attention. Using big EMR data, we have developed early disease risk prediction models for five common chronic diseases: diabetes, hypertension, CKD, COPD, and…
In this study, we investigated the application of bio-inspired optimization algorithms, including Genetic Algorithm, Particle Swarm Optimization, and Whale Optimization Algorithm, for feature selection in chronic disease prediction. The…
Today there exists no shortage of outlier detection algorithms in the literature, yet the complementary and critical problem of unsupervised outlier model selection (UOMS) is vastly understudied. In this work we propose ELECT, a new…
Compositional data, where only relative abundances are available, are common in microbiome and other high-throughput sequencing studies. Log ratios between groups of variables serve as key biomarkers in these settings. However, selecting…
Survival prediction with small sets of features is a highly relevant topic for decision-making in clinical practice. I describe a method for predicting survival of amyotrophic lateral sclerosis (ALS) patients that was developed as a…
High-throughput microarray and sequencing technology have been used to identify disease subtypes that could not be observed otherwise by using clinical variables alone. The classical unsupervised clustering strategy concerns primarily the…
The centrality and diversity of the labeled data are very influential to the performance of semi-supervised learning (SSL), but most SSL models select the labeled data randomly. This study first construct a leading forest that forms a…
With the increasing availability of data for Prognostics and Health Management (PHM), Deep Learning (DL) techniques are now the subject of considerable attention for this application, often achieving more accurate Remaining Useful Life…
Hypertension is a major risk factor for stroke, cardiovascular disease, and end-stage renal disease, and its prevalence is expected to rise dramatically. Effective hypertension management is thus critical. A particular priority is…
Prognostics or Remaining Useful Life (RUL) Estimation from multi-sensor time series data is useful to enable condition-based maintenance and ensure high operational availability of equipment. We propose a novel deep learning based approach…
Stroke remains a leading cause of death and disability worldwide, yet effective prediction of stroke risk using large-scale population data remains challenging due to data imbalance and high-dimensional features. In this study, we develop…
Deep learning models have shown a great effectiveness in recognition of findings in medical images. However, they cannot handle the ever-changing clinical environment, bringing newly annotated medical data from different sources. To exploit…
Electronic Health Records (EHRs) enable deep learning for clinical predictions, but the optimal method for representing patient data remains unclear due to inconsistent evaluation practices. We present the first systematic benchmark to…
In traditional logistic regression models, the link function is often assumed to be linear and continuous in predictors. Here, we consider a threshold model that all continuous features are discretized into ordinal levels, which further…
In biomedical studies, it is often desirable to characterize the interactive mode of multiple disease outcomes beyond their marginal risk. Ising model is one of the most popular choices serving for this purpose. Nevertheless, learning…
It is of paramount importance to enhance medical practices, given how important it is to protect human life. Medical therapy can be accelerated by automating patient prediction using machine learning techniques. To double the efficiency of…
Monitoring the health status of patients and predicting mortality in advance is vital for providing patients with timely care and treatment. Massive medical signs in electronic health records (EHR) are fitted into advanced machine learning…
Effective feature selection is essential for high-dimensional data analysis and machine learning. Unsupervised feature selection (UFS) aims to simultaneously cluster data and identify the most discriminative features. Most existing UFS…
Brain stroke remains one of the principal causes of death and disability worldwide, yet most tabular-data prediction models still hover below the 95% accuracy threshold, limiting real-world utility. Addressing this gap, the present work…