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We introduce GENomic Encoding REpresentation with Language Model (GENEREL), a framework designed to bridge genetic and biomedical knowledge bases. What sets GENEREL apart is its ability to fine-tune language models to infuse biological…

Machine Learning · Computer Science 2024-10-15 Hongyi Yuan , Suqi Liu , Kelly Cho , Katherine Liao , Alexandre Pereira , Tianxi Cai

Recent work incorporates pre-trained word embeddings such as BERT embeddings into Neural Topic Models (NTMs), generating highly coherent topics. However, with high-quality contextualized document representations, do we really need…

Computation and Language · Computer Science 2022-04-22 Zihan Zhang , Meng Fang , Ling Chen , Mohammad-Reza Namazi-Rad

Medical concept normalization helps in discovering standard concepts in free-form text i.e., maps health-related mentions to standard concepts in a vocabulary. It is much beyond simple string matching and requires a deep semantic…

Computation and Language · Computer Science 2020-06-09 Katikapalli Subramanyam Kalyan , S. Sangeetha

AI-enabled precision medicine promises a transformational improvement in healthcare outcomes by enabling data-driven personalized diagnosis, prognosis, and treatment. However, the well-known "curse of dimensionality" and the clustered…

Machine Learning · Computer Science 2023-05-19 Amanda M. Buch , Conor Liston , Logan Grosenick

Understanding patient feedback is crucial for improving healthcare services, yet analyzing unlabeled short-text feedback presents challenges due to limited data and domain-specific nuances. Traditional supervised approaches require…

Machine Learning · Computer Science 2026-01-21 K M Sajjadul Islam , Ravi Teja Karri , Srujan Vegesna , Jiawei Wu , Praveen Madiraju

Recently, the performance of Pre-trained Language Models (PLMs) has been significantly improved by injecting knowledge facts to enhance their abilities of language understanding. For medical domains, the background knowledge sources are…

Computation and Language · Computer Science 2021-08-23 Taolin Zhang , Zerui Cai , Chengyu Wang , Minghui Qiu , Bite Yang , Xiaofeng He

In this paper, we propose a novel approach for text classification based on clustering word embeddings, inspired by the bag of visual words model, which is widely used in computer vision. After each word in a collection of documents is…

Computation and Language · Computer Science 2017-07-26 Andrei M. Butnaru , Radu Tudor Ionescu

Representation learning methods that transform encoded data (e.g., diagnosis and drug codes) into continuous vector spaces (i.e., vector embeddings) are critical for the application of deep learning in healthcare. Initial work in this area…

Machine Learning · Computer Science 2019-07-23 Khushbu Agarwal , Tome Eftimov , Raghavendra Addanki , Sutanay Choudhury , Suzanne Tamang , Robert Rallo

State-of-the-art clustering algorithms use heuristics to partition the feature space and provide little insight into the rationale for cluster membership, limiting their interpretability. In healthcare applications, the latter poses a…

Machine Learning · Statistics 2018-12-04 Dimitris Bertsimas , Agni Orfanoudaki , Holly Wiberg

Knowledge graphs are freely aggregated, published, and edited in the Web of data, and thus may overlap. Hence, a key task resides in aligning (or matching) their content. This task encompasses the identification, within an aggregated…

Machine Learning · Computer Science 2021-10-22 Pierre Monnin , Chedy Raïssi , Amedeo Napoli , Adrien Coulet

Graph contrastive learning defines a contrastive task to pull similar instances close and push dissimilar instances away. It learns discriminative node embeddings without supervised labels, which has aroused increasing attention in the past…

Machine Learning · Computer Science 2023-04-25 Lin Shu , Chuan Chen , Zibin Zheng

Biomedical knowledge graphs (BioMedKGs) are essential infrastructures for biomedical and healthcare big data and artificial intelligence (AI), facilitating natural language processing, model development, and data exchange. For decades,…

This research aims to develop a dynamic and scalable framework to facilitate harmonization of Common Data Elements (CDEs) across heterogeneous biomedical datasets by addressing challenges such as semantic heterogeneity, structural…

Information Retrieval · Computer Science 2025-06-04 Madan Krishnamurthy , Daniel Korn , Melissa A Haendel , Christopher J Mungall , Anne E Thessen

With the development of medical imaging technology and machine learning, computer-assisted diagnosis which can provide impressive reference to pathologists, attracts extensive research interests. The exponential growth of medical images and…

Computer Vision and Pattern Recognition · Computer Science 2020-10-08 Xiao Kang , Xingbo Liu , Xiushan Nie , Yilong Yin

Clinical notes contain rich clinical narratives but their unstructured format poses challenges for large-scale analysis. Standardized terminologies such as SNOMED CT improve interoperability, yet understanding how concepts relate through…

Computation and Language · Computer Science 2025-09-05 Ali Noori , Somya Mohanty , Prashanti Manda

Biomedical word sense disambiguation (WSD) is an important intermediate task in many natural language processing applications such as named entity recognition, syntactic parsing, and relation extraction. In this paper, we employ…

Computation and Language · Computer Science 2017-10-03 A. K. M. Sabbir , Antonio Jimeno Yepes , Ramakanth Kavuluru

Learning vectorized embeddings is fundamental to many recommender systems for user-item matching. To enable efficient online inference, representation binarization, which embeds latent features into compact binary sequences, has recently…

Information Retrieval · Computer Science 2025-06-04 Yankai Chen , Yue Que , Xinni Zhang , Chen Ma , Irwin King

Contextual word embedding models, such as BioBERT and Bio_ClinicalBERT, have achieved state-of-the-art results in biomedical natural language processing tasks by focusing their pre-training process on domain-specific corpora. However, such…

Computation and Language · Computer Science 2021-06-04 George Michalopoulos , Yuanxin Wang , Hussam Kaka , Helen Chen , Alexander Wong

There have been some works that learn a lexicon together with the corpus to improve the word embeddings. However, they either model the lexicon separately but update the neural networks for both the corpus and the lexicon by the same…

Computation and Language · Computer Science 2017-07-25 Yuanzhi Ke , Masafumi Hagiwara

Distributed representations of medical concepts have been used to support downstream clinical tasks recently. Electronic Health Records (EHR) capture different aspects of patients' hospital encounters and serve as a rich source for…

Computation and Language · Computer Science 2020-01-07 Shaika Chowdhury , Chenwei Zhang , Philip S. Yu , Yuan Luo