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Distance-based metrics, such as the Hausdorff distance (HD), are widely used to validate segmentation performance in (bio)medical imaging. However, their implementation is complex, and critical differences across open-source tools remain…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Gasper Podobnik , Tomaz Vrtovec

Overlap-based metrics such as the Dice Similarity Coefficient (DSC) penalize segmentation errors more heavily in smaller structures. As organ size differs by sex, this implies that a segmentation error of equal magnitude may result in lower…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Hartmut Häntze , Myrthe Buser , Alessa Hering , Lisa C. Adams , Keno K. Bressem

Current medical image segmentation relies on the region-based (Dice, F1-score) and boundary-based (Hausdorff distance, surface distance) metrics as the de-facto standard. While these metrics are widely used, they lack a unified…

Image and Video Processing · Electrical Eng. & Systems 2024-05-15 Zheyuan Zhang , Ulas Bagci

The Hausdorff Distance (HD) is widely used in evaluating medical image segmentation methods. However, existing segmentation methods do not attempt to reduce HD directly. In this paper, we present novel loss functions for training…

Image and Video Processing · Electrical Eng. & Systems 2019-04-24 Davood Karimi , Septimiu E. Salcudean

Accurate automated detection of recurrent prostate cancer in PSMA PET/CT scans is challenging due to heterogeneous lesion size, activity, anatomical location, and intra- and inter-class imbalances. Conventional deep learning loss functions…

Image and Video Processing · Electrical Eng. & Systems 2026-03-17 Obed Korshie Dzikunu , Shadab Ahamed , Amirhossein Toosi , Xiaoxiao Li , Arman Rahmim

The development of automatic segmentation techniques for medical imaging tasks requires assessment metrics to fairly judge and rank such approaches on benchmarks. The Dice Similarity Coefficient (DSC) is a popular choice for comparing the…

Image and Video Processing · Electrical Eng. & Systems 2023-02-13 Vatsal Raina , Nataliia Molchanova , Mara Graziani , Andrey Malinin , Henning Muller , Meritxell Bach Cuadra , Mark Gales

Deep learning (DL) networks have recently been shown to outperform other segmentation methods on various public, medical-image challenge datasets [3,11,16], especially for large pathologies. However, in the context of diseases such as…

Computer Vision and Pattern Recognition · Computer Science 2018-10-18 Tanya Nair , Doina Precup , Douglas L. Arnold , Tal Arbel

Within medical imaging segmentation, the Dice coefficient and Hausdorff-based metrics are standard measures of success for deep learning models. However, modern loss functions for medical image segmentation often only consider the Dice…

Image and Video Processing · Electrical Eng. & Systems 2024-01-26 Adrian Celaya , Beatrice Riviere , David Fuentes

Validation of image segmentation methods is of critical importance. Probabilistic image segmentation is increasingly popular as it captures uncertainty in the results. Image segmentation methods that support multi-region (as opposed to…

Computer Vision and Pattern Recognition · Computer Science 2015-10-14 Shawn Andrews , Ghassan Hamarneh

This paper focuses on the uncertainty estimation for white matter lesions (WML) segmentation in magnetic resonance imaging (MRI). On one side, voxel-scale segmentation errors cause the erroneous delineation of the lesions; on the other…

Image and Video Processing · Electrical Eng. & Systems 2023-11-16 Nataliia Molchanova , Vatsal Raina , Andrey Malinin , Francesco La Rosa , Henning Muller , Mark Gales , Cristina Granziera , Mara Graziani , Meritxell Bach Cuadra

Deep learning models (DLMs) can achieve state-of-the-art performance in histopathology image segmentation and classification, but have limited deployment potential in real-world clinical settings. Uncertainty estimates of DLMs can increase…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Audrey Xie , Elhoucine Elfatimi , Sambuddha Ghosal , Pratik Shah

Measuring cross-sectional areas in ultrasound images is a standard tool to evaluate disease progress or treatment response. Often addressed today with supervised deep-learning segmentation approaches, existing solutions highly depend upon…

Image and Video Processing · Electrical Eng. & Systems 2023-08-21 Vanessa Gonzalez Duque , Leonhard Zirus , Yordanka Velikova , Nassir Navab , Diana Mateus

Recent studies demonstrated the eligibility of convolutional neural networks (CNNs) for solving the image registration problem. CNNs enable faster transformation estimation and greater generalization capability needed for better support…

Image and Video Processing · Electrical Eng. & Systems 2021-02-10 Oleksii Bashkanov , Anneke Meyer , Daniel Schindele , Martin Schostak , Klaus Tönnies , Christian Hansen , Marko Rak

The assessment of segmentation quality plays a fundamental role in the development, optimization, and comparison of segmentation methods which are used in a wide range of applications. With few exceptions, quality assessment is performed…

Computer Vision and Pattern Recognition · Computer Science 2025-04-02 Niklas Rottmayer , Claudia Redenbach

We utilized a 3D nnU-Net model with residual layers supplemented by squeeze and excitation (SE) normalization for tumor segmentation from PET/CT images provided by the Head and Neck Tumor segmentation chal-lenge (HECKTOR). Our proposed loss…

The Dice similarity coefficient (DSC) is both a widely used metric and loss function for biomedical image segmentation due to its robustness to class imbalance. However, it is well known that the DSC loss is poorly calibrated, resulting in…

Image and Video Processing · Electrical Eng. & Systems 2022-11-02 Michael Yeung , Leonardo Rundo , Yang Nan , Evis Sala , Carola-Bibiane Schönlieb , Guang Yang

In the last decade, research on artificial intelligence has seen rapid growth with deep learning models, especially in the field of medical image segmentation. Various studies demonstrated that these models have powerful prediction…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Dominik Müller , Iñaki Soto-Rey , Frank Kramer

Deep convolutional neural networks are widely used in medical image segmentation but require many labeled images for training. Annotating three-dimensional medical images is a time-consuming and costly process. To overcome this limitation,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Weiyi Xie , Nathalie Willems , Nikolas Lessmann , Tom Gibbons , Daniele De Massari

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is a valuable tool to localize, characterize, and evaluate anomalous prostate tissue. Ultrafast gradient-echo acquisitions of MRI volumes are generated at regular time intervals…

Medical Physics · Physics 2017-10-11 Wuilian Torres , Leonardo Cordero , Miguel Martín-Landrove , Antonio Rueda-Toicen

In this paper, we demonstrate the feasibility and performance of deep residual neural networks for volumetric segmentation of irreversibly damaged brain tissue lesions on T1-weighted MRI scans for chronic stroke patients. A total of 239…

Image and Video Processing · Electrical Eng. & Systems 2019-11-27 Naofumi Tomita , Steven Jiang , Matthew E. Maeder , Saeed Hassanpour
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