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Quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) simulations have been developed to simulate molecular systems, where an explicit description of changes in the electronic structure is necessary. However, QM/MM MD…

Chemical Physics · Physics 2021-04-15 Lennard Böselt , Moritz Thürlemann , Sereina Riniker

Two-sample tests have been extensively employed in various scientific fields and machine learning such as evaluation on the effectiveness of drugs and A/B testing on different marketing strategies to discriminate whether two sets of samples…

Quantum Physics · Physics 2025-11-27 Yu Terada , Yugo Ogio , Ken Arai , Hiroyuki Tezuka , Yu Tanaka

The mechanical properties of molecules are today captured by single molecule manipulation experiments, so that polymer features are tested at a nanometric scale. Yet devising mathematical models to get further insight beyond the commonly…

Quantum machine learning techniques are commonly considered one of the most promising candidates for demonstrating practical quantum advantage. In particular, quantum kernel methods have been demonstrated to be able to learn certain…

Quantum reinforcement learning (QRL) models augment classical reinforcement learning schemes with quantum-enhanced kernels. Different proposals on how to construct such models empirically show a promising performance. In particular, these…

Coarse-graining (CG) enables molecular dynamics (MD) simulations of larger systems and longer timescales that are otherwise infeasible with atomistic models. Machine learning potentials (MLPs), with their capacity to capture many-body…

Chemical Physics · Physics 2025-12-01 Weilong Chen , Franz Görlich , Paul Fuchs , Julija Zavadlav

Gradient-domain machine learning (GDML) is an accurate and efficient approach to learn a molecular potential and associated force field based on the kernel ridge regression algorithm. Here, we demonstrate its application to learn an…

Computational Physics · Physics 2020-06-24 Jiang Wang , Stefan Chmiela , Klaus-Robert Müller , Frank Noè , Cecilia Clementi

Quantum machine learning is a rapidly growing field at the intersection of quantum technology and artificial intelligence. This review provides a two-fold overview of several key approaches that can offer advancements in both the…

Quantum Physics · Physics 2023-03-07 Alexey Melnikov , Mohammad Kordzanganeh , Alexander Alodjants , Ray-Kuang Lee

Molecular dynamics (MD) simulates the time evolution of atomic systems governed by interatomic forces, and the fidelity of these simulations depends critically on the underlying force model. Classical force fields (CFFs) rely on fixed…

Performance · Computer Science 2026-03-05 Udari De Alwis , Benjamin E. Mayer , Tom J. Ashby , Maria Barrera , Timon Evenblij , Joyjit Kundu

Classical machine learning, extensively utilized across diverse domains, faces limitations in speed, efficiency, parallelism, and processing of complex datasets. In contrast, quantum machine learning algorithms offer significant advantages,…

Quantum Physics · Physics 2024-06-05 Anand Babu , Saurabh G. Ghatnekar , Amit Saxena , Dipankar Mandal

Quantum and classical machine learning have been naturally connected through kernel methods, which have also served as proof-of-concept for quantum advantage. Quantum embeddings encode classical data into quantum feature states, enabling…

Quantum Physics · Physics 2025-07-01 Pablo Rodriguez-Grasa , Yue Ban , Mikel Sanz

Quantum computers progress toward outperforming classical supercomputers, but quantum errors remain their primary obstacle. The key to overcoming errors on near-term devices has emerged through the field of quantum error mitigation,…

Quantum Physics · Physics 2025-05-14 Haoran Liao , Derek S. Wang , Iskandar Sitdikov , Ciro Salcedo , Alireza Seif , Zlatko K. Minev

We perform quantum simulation on classical and quantum computers and set up a machine learning framework in which we can map out phase diagrams of known and unknown quantum many-body systems in an unsupervised fashion. The classical…

Quantum Physics · Physics 2022-10-21 Korbinian Kottmann

Using conservation of energy - a fundamental property of closed classical and quantum mechanical systems - we develop an efficient gradient-domain machine learning (GDML) approach to construct accurate molecular force fields using a…

One of the main challenges in drug discovery is to find molecules that bind specifically and strongly to their target protein while having minimal binding to other proteins. By predicting binding affinity, it is possible to identify the…

Quantum Physics · Physics 2023-01-19 L. Domingo , M. Djukic , C. Johnson , F. Borondo

A novel method combining the ensemble refinement by maximum entropy principle and the force field fitting approach is presented. Its formulation allows to continuously interpolate in between these two methods, which can thus be interpreted…

Chemical Physics · Physics 2024-01-30 Ivan Gilardoni , Thorben Fröhlking , Giovanni Bussi

To address the computational challenges of ab initio molecular dynamics and the accuracy limitations of empirical force fields, the introduction of machine learning force fields has proven effective in various systems including metals and…

Soft Condensed Matter · Physics 2023-12-18 Junbao Hu , Liyang Zhou , Jian Jiang

Machine learning force fields show great promise in enabling more accurate molecular dynamics simulations compared to manually derived ones. Much of the progress in recent years was driven by exploiting prior knowledge about physical…

Machine Learning · Computer Science 2025-09-11 Andreas Burger , Luca Thiede , Alán Aspuru-Guzik , Nandita Vijaykumar

The advent of hybrid computing platforms consisting of quantum processing units integrated with conventional high-performance computing brings new opportunities for algorithm design. By strategically offloading select portions of the…

Quantum-enhanced machine learning is a rapidly evolving field that aims to leverage the unique properties of quantum mechanics to enhance classical machine learning. However, the practical applicability of these methods remains an open…

Quantum Physics · Physics 2025-02-18 Diego Alvarez-Estevez