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We present a robust data-driven machine learning analysis of the COVID-19 pandemic from its early infection dynamics, specifically infection counts over time. The goal is to extract actionable public health insights. These insights include…

Populations and Evolution · Quantitative Biology 2020-04-06 Malik Magdon-Ismail

In this paper, we explore whether the infection-rate of a disease can serve as a robust monitoring variable in epidemiological surveillance algorithms. The infection-rate is dependent on population mixing patterns that do not vary…

Applications · Statistics 2024-07-17 Wyatt Bridgman , Cosmin Safta , Jaideep Ray

Background: The COVID-19 pandemic has had a profound impact on health, everyday life and economics around the world. An important complication that can arise in connection with a COVID-19 infection is acute kidney injury. A recent…

The COVID-19 pandemic has caused major disturbance to human life. An important reason behind the widespread social anxiety is the huge uncertainty about the pandemic. A fundamental uncertainty is how many or what percentage of people have…

Populations and Evolution · Quantitative Biology 2021-03-04 Donghui Yan , Ying Xu , Pei Wang

Following the emergence of a novel coronavirus (SARS-CoV-2) and its spread outside of China, Europe has experienced large epidemics. In response, many European countries have implemented unprecedented non-pharmaceutical interventions…

We describe a class of algorithms for evaluating posterior moments of certain Bayesian linear regression models with a normal likelihood and a normal prior on the regression coefficients. The proposed methods can be used for hierarchical…

Computation · Statistics 2021-10-08 Philip Greengard , Jeremy Hoskins , Charles C. Margossian , Andrew Gelman , Aki Vehtari

We propose a framework for Bayesian non-parametric estimation of the rate at which new infections occur assuming that the epidemic is partially observed. The developed methodology relies on modelling the rate at which new infections occur…

Methodology · Statistics 2014-12-16 Edward S. Knock , Theodore Kypraios

Ivermectin is an antiparasitic drug that some have claimed is an effective treatment for reducing Covid-19 deaths. To test this claim, two recent peer reviewed papers both conducted a meta-analysis on a similar set of randomized controlled…

Quantitative Methods · Quantitative Biology 2021-10-04 Martin Neil , Norman Fenton

The long duration of the COVID-19 pandemic allowed for multiple bursts in the infection and death rates, the so-called epidemic waves. This complex behavior is no longer tractable by simple compartmental model and requires more…

To make informative public policy decisions in battling the ongoing COVID-19 pandemic, it is important to know the disease prevalence in a population. There are two intertwined difficulties in estimating this prevalence based on testing…

Methodology · Statistics 2020-12-01 Bryan Cai , John P. A. Ioannidis , Eran Bendavid , Lu Tian

Large-scale testing is considered key to assess the state of the current COVID-19 pandemic. Yet, the link between the reported case numbers and the true state of the pandemic remains elusive. We develop mathematical models based on…

Applications · Statistics 2021-02-04 Michel Besserve , Simon Buchholz , Bernhard Schölkopf

This paper deals with the problem of estimating variables in nonlinear models for the spread of disease and its application to the COVID-19 epidemic. First unconstrained methods are revisited and they are shown to correspond to the…

Optimization and Control · Mathematics 2020-08-20 Mauricio C. de Oliveira

Meta-analysis aims to generalize results from multiple related statistical analyses through a combined analysis. While the natural outcome of a Bayesian study is a posterior distribution, traditional Bayesian meta-analyses proceed by…

Following [Diggle 2011, Greenland 1995], we give a simple formula for the Bayesian posterior density of a prevalence parameter based on unreliable testing of a population. This problem is of particular importance when the false positive…

Applications · Statistics 2020-09-14 Jonathan Baxter

We present a workflow for clinical data analysis that relies on Bayesian Structure Learning (BSL), an unsupervised learning approach, robust to noise and biases, that allows to incorporate prior medical knowledge into the learning process…

Machine Learning · Computer Science 2022-10-12 Elisa Ferrari , Luna Gargani , Greta Barbieri , Lorenzo Ghiadoni , Francesco Faita , Davide Bacciu

Objectives: To provide an overall quality assessment of the methods used for COVID-19-related studies using propensity score matching (PSM). Study Design and Setting: A systematic search was conducted in June 2021 on PubMed to identify…

Other Quantitative Biology · Quantitative Biology 2024-03-13 Chunhui Gu , Ruosha Li , Guoqiang Zhang

Non-representative surveys are commonly used and widely available but suffer from selection bias that generally cannot be entirely eliminated using weighting techniques. Instead, we propose a Bayesian method to synthesize longitudinal…

Methodology · Statistics 2024-07-08 Nathaniel Dyrkton , Paul Gustafson , Harlan Campbell

Because of the rapid spread of COVID-19 to almost every part of the globe, huge volumes of data and case studies have been made available, providing researchers with a unique opportunity to find trends and make discoveries like never…

Machine Learning · Computer Science 2021-10-20 Sarwan Ali , Yijing Zhou , Murray Patterson

Modern Bayesian approaches and workflows emphasize in how simulation is important in the context of model developing. Simulation can help researchers understand how the model behaves in a controlled setting and can be used to stress the…

Classical epidemiological models assume homogeneous populations. There have been important extensions to model heterogeneous populations, when the identity of the sub-populations is known, such as age group or geographical location. Here,…

Machine Learning · Computer Science 2023-02-10 Roberto Vega , Zehra Shah , Pouria Ramazi , Russell Greiner