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Quadratic Unconstrained Binary Optimization (QUBO) provides a versatile framework for representing NP-hard combinatorial problems, yet existing solvers often face trade-offs among speed, accuracy, and scalability. In this work, we introduce…

Quantum Physics · Physics 2025-06-06 Jiecheng Yang , Ding Wang , Xiang Zhao , Hairui Zhang , Ming Gao , Lin Yang

The peptide-protein docking problem is an important problem in structural biology that facilitates rational and efficient drug design. In this work, we explore modeling and solving this problem with the quantum-amenable quadratic…

We propose a complete quantum-classical hybrid branch-and-bound algorithm (QCBB) to solve binary linear programs with equality constraints. That includes bound calculation, convergence metrics and optimality guarantee to the quantum…

Quantum Physics · Physics 2026-02-03 András Czégel , Dávid Sipos , Boglárka G. -Tóth

We propose and analyze a set of variational quantum algorithms for solving quadratic unconstrained binary optimization problems where a problem consisting of $n_c$ classical variables can be implemented on $\mathcal O(\log n_c)$ number of…

Quantum optimization solvers typically rely on one-variable-to-one-qubit mapping. However, the low qubit count on current quantum computers is a major obstacle in competing against classical methods. Here, we develop a qubit-efficient…

Quantum Physics · Physics 2026-03-24 Bhuvanesh Sundar , Maxime Dupont

With the advent of quantum computers, many quantum computing algorithms are being developed. Solving linear systems is one of the most fundamental problems in almost all science and engineering. The Harrow-Hassidim-Lloyd algorithm, a…

Quantum Physics · Physics 2022-01-25 Kyungtaek Jun

Solving combinatorial optimization problems of the kind that can be codified by quadratic unconstrained binary optimization (QUBO) is a promising application of quantum computation. Some problems of this class suitable for practical…

In solving optimization problems, objective functions generally need to be minimized or maximized. However, objective functions cannot always be formulated explicitly in a mathematical form for complicated problem settings. Although several…

Statistical Mechanics · Physics 2021-07-20 Ami S. Koshikawa , Masayuki Ohzeki , Tadashi Kadowaki , Kazuyuki Tanaka

Quadratic unconstrained binary optimization (QUBO) problems are well-studied, not least because they can be approached using contemporary quantum annealing or classical hardware acceleration. However, due to limited precision and hardware…

Quantum Physics · Physics 2023-07-06 Sascha Mücke , Thore Gerlach , Nico Piatkowski

We propose an enhanced zeroth-order stochastic Frank-Wolfe framework to address constrained finite-sum optimization problems, a structure prevalent in large-scale machine-learning applications. Our method introduces a novel double variance…

Machine Learning · Computer Science 2025-01-24 Haishan Ye , Yinghui Huang , Hao Di , Xiangyu Chang

Obtaining Quadratic Unconstrained Binary Optimisation models for various optimisation problems, in order to solve those on physical quantum computers (such as the the DWave annealers) is nowadays a lengthy and tedious process that requires…

Mathematical Software · Computer Science 2023-07-20 Armin Wolf , Cristian Grozea

NP problems are closely related to practical optimization challenges but often suffer from exponential increases in computation time as problem sizes grow. Quantum annealing offers a promising approach to solve NP problems faster than…

Quantum Physics · Physics 2025-04-14 Toru Fujii , Koshi Komuro , Kaito Tomari

Quantum annealers are specialized quantum computers for solving combinatorial optimization problems using special characteristics of quantum computing (QC), such as superposition, entanglement, and quantum tunneling. Theoretically, quantum…

Software Engineering · Computer Science 2024-07-29 Xinyi Wang , Asmar Muqeet , Tao Yue , Shaukat Ali , Paolo Arcaini

Quantum approximate optimization is one of the promising candidates for useful quantum computation, particularly in the context of finding approximate solutions to Quadratic Unconstrained Binary Optimization (QUBO) problems. However, the…

The problem of selecting an appropriate number of features in supervised learning problems is investigated in this paper. Starting with common methods in machine learning, we treat the feature selection task as a quadratic unconstrained…

Quantum Physics · Physics 2023-06-21 Gerhard Hellstern , Vanessa Dehn , Martin Zaefferer

Numerous established machine learning models and various neural network architectures can be restructured as Quadratic Unconstrained Binary Optimization (QUBO) problems. A significant challenge in Adiabatic Quantum Machine Learning (AQML)…

Quantum Physics · Physics 2025-05-15 Bahram Alidaee , Haibo Wang , Lutfu Sua , Wade Liu

Simulated annealing (SA) is a key algorithm for solving combinatorial optimization problems, which model numerous real-world systems. While SA is commonly used to solve quadratic unconstrained binary optimization (QUBO) problems, many…

Statistical Mechanics · Physics 2026-05-05 Kohei Suzuki

Quantum computing exploits basic quantum phenomena such as state superposition and entanglement to perform computations. The Quantum Approximate Optimization Algorithm (QAOA) is arguably one of the leading quantum algorithms that can…

Machine Learning · Computer Science 2022-06-16 Sami Khairy , Ruslan Shaydulin , Lukasz Cincio , Yuri Alexeev , Prasanna Balaprakash

This paper addresses the Quadratic Multiple Constraints Variable-Sized Bin Packing Problem (QMC-VSBPP), a challenging combinatorial optimization problem that generalizes the classical bin packing problem by incorporating multiple capacity…

Neural and Evolutionary Computing · Computer Science 2026-03-27 Natalia A. Santos , Marlon Jeske , Antonio A. Chaves

The focus of this work is to explore the use of quantum annealing solvers for the problem of phase unwrapping of synthetic aperture radar (SAR) images. Although solutions to this problem exist based on network programming, these techniques…

Computer Vision and Pattern Recognition · Computer Science 2020-10-02 Khaled A. Helal Kelany , Nikitas Dimopoulos , Clemens P. J. Adolphs , Bardia Barabadi , Amirali Baniasadi