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Predicting breast cancer recurrence risk is a critical clinical challenge. This study investigates the potential of computational pathology to stratify patients using deep learning on routine Hematoxylin and Eosin (H&E) stained whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Jinqiu Chen , Huyan Xu

Lung cancer is the leading cause of cancer death worldwide. The critical reason for the deaths is delayed diagnosis and poor prognosis. With the accelerated development of deep learning techniques, it has been successfully applied…

Image and Video Processing · Electrical Eng. & Systems 2021-06-15 Yujiao Wu , Jie Ma , Xiaoshui Huang , Sai Ho Ling , Steven Weidong Su

Histopathology Whole-Slide Images (WSIs) provide an important tool to assess cancer prognosis in computational pathology (CPATH). While existing survival analysis (SA) approaches have made exciting progress, they are generally limited to…

Computer Vision and Pattern Recognition · Computer Science 2025-02-12 Pei Liu , Luping Ji , Jiaxiang Gou , Bo Fu , Mao Ye

Automatic non-invasive assessment of hepatocellular carcinoma (HCC) malignancy has the potential to substantially enhance tumor treatment strategies for HCC patients. In this work we present a novel framework to automatically characterize…

Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…

Although melanoma occurs more rarely than several other skin cancers, patients' long term survival rate is extremely low if the diagnosis is missed. Diagnosis is complicated by a high discordance rate among pathologists when distinguishing…

Computer Vision and Pattern Recognition · Computer Science 2022-10-11 Sean Grullon , Vaughn Spurrier , Jiayi Zhao , Corey Chivers , Yang Jiang , Kiran Motaparthi , Michael Bonham , Julianna Ianni

Survival prediction for esophageal squamous cell cancer (ESCC) is crucial for doctors to assess a patient's condition and tailor treatment plans. The application and development of multi-modal deep learning in this field have attracted…

Image and Video Processing · Electrical Eng. & Systems 2024-08-27 Chengyu Wu , Yatao Zhang , Yaqi Wang , Qifeng Wang , Shuai Wang

Survival prediction based on whole slide images (WSIs) is a challenging task for patient-level multiple instance learning (MIL). Due to the vast amount of data for a patient (one or multiple gigapixels WSIs) and the irregularly shaped…

Computer Vision and Pattern Recognition · Computer Science 2023-07-03 Zhuchen Shao , Yang Chen , Hao Bian , Jian Zhang , Guojun Liu , Yongbing Zhang

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

In this paper, we describe a dataset relating to cellular and physical conditions of patients who are operated upon to remove colorectal tumours. This data provides a unique insight into immunological status at the point of tumour removal,…

Machine Learning · Computer Science 2016-11-17 Chris Roadknight , Uwe Aickelin , Guoping Qiu , John Scholefield , Lindy Durrant

Objective: Lung cancer is the leading cause of cancer-related death worldwide. Computer-aided diagnosis (CAD) systems have shown significant promise in recent years for facilitating the effective detection and classification of abnormal…

Computer Vision and Pattern Recognition · Computer Science 2019-01-16 Vignesh Sankar , Devinder Kumar , David A. Clausi , Graham W. Taylor , Alexander Wong

Multimodal machine learning integrating histopathology and molecular data shows promise for cancer prognostication. We systematically reviewed studies combining whole slide images (WSIs) and high-throughput omics to predict overall…

Quantitative Methods · Quantitative Biology 2025-07-30 Charlotte Jennings , Andrew Broad , Lucy Godson , Emily Clarke , David Westhead , Darren Treanor

Objective: This study explores a semi-supervised learning (SSL), pseudo-labeled strategy using diverse datasets to enhance lung cancer (LCa) survival predictions, analyzing Handcrafted and Deep Radiomic Features (HRF/DRF) from PET/CT scans…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Mohammad R. Salmanpour , Arman Gorji , Amin Mousavi , Ali Fathi Jouzdani , Nima Sanati , Mehdi Maghsudi , Bonnie Leung , Cheryl Ho , Ren Yuan , Arman Rahmim

Molecular subtypes of breast cancer are important references to personalized clinical treatment. For cost and labor savings, only one of the patient's paraffin blocks is usually selected for subsequent immunohistochemistry (IHC) to obtain…

Image and Video Processing · Electrical Eng. & Systems 2022-03-16 Hong Liu , Wen-Dong Xu , Zi-Hao Shang , Xiang-Dong Wang , Hai-Yan Zhou , Ke-Wen Ma , Huan Zhou , Jia-Lin Qi , Jia-Rui Jiang , Li-Lan Tan , Hui-Min Zeng , Hui-Juan Cai , Kuan-Song Wang , Yue-Liang Qian

Head and neck squamous cell carcinoma (HNSCC) presents significant challenges in clinical oncology due to its heterogeneity and high mortality rates. This study aims to leverage clinical data and machine learning (ML) principles to predict…

Quantitative Methods · Quantitative Biology 2025-02-18 Naman Dhariwal , Abeyankar Giridharan

The visual examination of tissue biopsy sections is fundamental for cancer diagnosis, with pathologists analyzing sections at multiple magnifications to discern tumor cells and their subtypes. However, existing attention-based multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Olga Fourkioti , Matt De Vries , Chen Jin , Daniel C. Alexander , Chris Bakal

Oral Squamous Cell Carcinoma (OSCC) is a prevalent and aggressive malignancy where deep learning-based computer-aided diagnosis and prognosis can enhance clinical assessments.However, existing publicly available OSCC datasets often suffer…

Image and Video Processing · Electrical Eng. & Systems 2025-07-23 Jinquan Guan , Junhong Guo , Qi Chen , Jian Chen , Yongkang Cai , Yilin He , Zhiquan Huang , Yan Wang , Yutong Xie

Accurate prediction of the likelihood of recurrence is important in the selection of postoperative treatment for patients with early-stage breast cancer. In this study, we investigated whether deep learning algorithms can predict patients'…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Geongyu Lee , Joonho Lee , Tae-Yeong Kwak , Sun Woo Kim , Youngmee Kwon , Chungyeul Kim , Hyeyoon Chang

Whole Slide Image (WSI) analysis, with its ability to reveal detailed tissue structures in magnified views, plays a crucial role in cancer diagnosis and prognosis. Due to their giga-sized nature, WSIs require substantial storage and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Doanh Cao Bui , Jin Tae Kwak

Background: CT imaging is vital for lung cancer management, offering detailed visualization for AI-based prognosis. However, supervised learning SL models require large labeled datasets, limiting their real-world application in settings…