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In biology, predicting RNA secondary structures plays a vital role in determining its physical and chemical properties. Although we have powerful energy models to predict them as well as parametric analysis to understand the models…

Biomolecules · Quantitative Biology 2023-05-01 Doan Dai Nguyen

Living organisms rely on molecular networks, such as gene circuits and signaling pathways, for information processing and robust decision-making in crowded, noisy environments. Recent advances show that interacting biomolecules…

Modern deep-learning systems are specialized to problem settings in which training occurs once and then never again, as opposed to continual-learning settings in which training occurs continually. If deep-learning systems are applied in a…

Machine Learning · Computer Science 2024-04-11 Shibhansh Dohare , J. Fernando Hernandez-Garcia , Parash Rahman , A. Rupam Mahmood , Richard S. Sutton

The rich polymorphism exhibited by inorganic/organic interfaces is a major challenge for materials design. In this work we present a method to efficiently explore the potential energy surface and predict the formation energies of polymorphs…

Neuroevolution is an alternative to gradient-based optimisation that has the potential to avoid local minima and allows parallelisation. The main limiting factor is that usually it does not scale well with parameter space dimensionality.…

Machine Learning · Computer Science 2021-04-29 Nemanja Rakicevic , Antoine Cully , Petar Kormushev

Current methods for microplastic identification in water samples are costly and require expert analysis. Here, we propose a deep learning segmentation model to automatically identify microplastics in microscopic images. We labeled images of…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Alex Dils , David Raymond , Jack Spottiswood , Samay Kodige , Dylan Karmin , Rikhil Kokal , Win Cowger , Chris Sadée

There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell…

Quantitative Methods · Quantitative Biology 2020-02-26 Finn Kuusisto , Vitor Santos Costa , Zhonggang Hou , James Thomson , David Page , Ron Stewart

CMOS-based computing systems that employ the von Neumann architecture are relatively limited when it comes to parallel data storage and processing. In contrast, the human brain is a living computational signal processing unit that operates…

Mesoscale and Nanoscale Physics · Physics 2022-08-02 Dmitry Kireev , Samuel Liu , Harrison Jin , T. Patrick Xiao , Christopher H. Bennett , Deji Akinwande , Jean Anne Incorvia

The feedback alignment (FA) algorithm offers a biologically plausible alternative to backpropagation (BP) for training neural networks yet notably fails to scale to convolutional architectures. Modifications have been proposed to address…

Artificial Intelligence · Computer Science 2026-05-12 Jake Lance , Larry Kieu

The microstructure of the Ti-Al binary system is an area of great interest as it affects material properties and plasticity. Phase transformations induce microstructural changes; therefore, accurately modeling the phase transformations of…

Materials Science · Physics 2024-11-13 Micah Nichols , Christopher D. Barrett , Doyl E. Dickel , Mashroor S. Nitol , Saryu J. Fensin

Underpinning the past decades of work on the design, initialization, and optimization of neural networks is a seemingly innocuous assumption: that the network is trained on a \textit{stationary} data distribution. In settings where this…

Machine Learning · Computer Science 2024-03-01 Clare Lyle , Zeyu Zheng , Khimya Khetarpal , Hado van Hasselt , Razvan Pascanu , James Martens , Will Dabney

As we passed the 20th anniversary of the publication of the 12 principles of green chemistry, the sustainable modification of cellulose, being the most abundant biobased polymer, is certainly worth considering. Many researchers work on an…

Applied Physics · Physics 2019-11-19 Kelechukwu Onwukamike , Stéphane Grelier , Etienne Grau , Henri Cramail , Michael Meier

Despite great advances, molecular cancer pathology is often limited to the use of a small number of biomarkers rather than the whole transcriptome, partly due to computational challenges. Here, we introduce a novel architecture of Deep…

Machine Learning · Statistics 2019-08-14 Behrooz Azarkhalili , Ali Saberi , Hamidreza Chitsaz , Ali Sharifi-Zarchi

While deep neural networks have surpassed human performance in multiple situations, they are prone to catastrophic forgetting: upon training a new task, they rapidly forget previously learned ones. Neuroscience studies, based on idealized…

Neural and Evolutionary Computing · Computer Science 2021-03-24 Axel Laborieux , Maxence Ernoult , Tifenn Hirtzlin , Damien Querlioz

The importance of plastic waste recycling is undeniable. In this respect, computer vision and deep learning enable solutions through the automated analysis of short-wave-infrared hyper-spectral images of plastics. In this paper, we offer an…

Computer Vision and Pattern Recognition · Computer Science 2022-03-23 Klaas Dijkstra , Maya Aghaei , Femke Jaarsma , Martin Dijkstra , Rudy Folkersma , Jan Jager , Jaap van de Loosdrecht

Crystal-graph attention networks have emerged recently as remarkable tools for the prediction of thermodynamic stability and materials properties from unrelaxed crystal structures. Previous networks trained on two million materials…

Emerging multi-material 3D printing techniques have paved the way for the rational design of metamaterials with not only complex geometries but also arbitrary distributions of multiple materials within those geometries. Varying the spatial…

Materials Science · Physics 2022-04-06 H. Pahlavani , M. Amani , M. Cruz Saldívar , J. Zhou , M. J. Mirzaali , A. A. Zadpoor

Conjugated organic molecules represent an important area of materials chemistry for both fundamental scientific exploration and technological applications. Using a genetic algorithm to computationally screen up to ~25-50 million molecules…

Applied Physics · Physics 2017-07-14 Ilana Y. Kanal , Geoffrey R. Hutchison

Interest in biologically inspired alternatives to backpropagation is driven by the desire to both advance connections between deep learning and neuroscience and address backpropagation's shortcomings on tasks such as online, continual…

Neural and Evolutionary Computing · Computer Science 2020-06-18 Jack Lindsey , Ashok Litwin-Kumar

There has been rapidly growing demand of polymeric materials coming from different aspects of modern life because of the highly diverse physical and chemical properties of polymers. Polymer informatics is an interdisciplinary research field…

Soft Condensed Matter · Physics 2020-10-16 Stephen Wu , Hironao Yamada , Yoshihiro Hayashi , Massimiliano Zamengo , Ryo Yoshida