Related papers: Transformative Technology for FLASH Radiation Ther…
Purpose: A novel rotating gamma stereotactic radiosurgery (SRS) system (Galaxy RTi) with real-time image guidance technology has been developed for high-precision SRS and frameless fractionated stereotactic radiotherapy (SRT). This work…
The predicted increase in the number of patients receiving radiation therapy (RT) to treat cancer calls for an optimized use of resources. To manually schedule patients on the linear accelerators delivering RT is a time-consuming and…
Radiation therapy has remained as one of the main cancer treatment modalities and a highly cost-effective single modality treatment of cancer care. Typical regimens for fractionated external beam radiotherapy comprise a constant dose…
Deep learning has facilitated the automation of radiotherapy by predicting accurate dose distribution maps. However, existing methods fail to derive the desirable radiotherapy parameters that can be directly input into the treatment…
Rapid technological advances in radiation therapy have significantly improved dose delivery and tumor control for head and neck cancers. However, treatment-related toxicities caused by high-dose exposure to critical structures remain a…
Radiotherapy is one of the primary treatment methods for tumors, but the organ movement caused by respiration limits its accuracy. Recently, 3D imaging from a single X-ray projection has received extensive attention as a promising approach…
{\bf Purpose}: To develop a geometry-governed diffusion framework that explains differential tissue response under FLASH ultra-high dose rate (UHDR) irradiation by explicitly accounting for structural heterogeneity and anomalous transport…
With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…
The future of ART in head and neck cancer is just beginning. Novel technologies have pushed the boundary of what is possible in terms of techniques to identify biomarkers for adaptation as well as innovative devices specialized to respond…
Theranostics, the combination of diagnosis and therapy, has long held promise as a means to achieving personalised precision cancer treatments. However, despite its potential, theranostics has yet to realise significant clinical…
The FLASH effect refers to a lower normal tissue damage for an equivalent tumour response, potentially widening the therapeutic window for radiotherapy. Although this effect has been demonstrated in various experiments using different types…
Purpose: A promising approach to enable FLASH conformal proton therapy is to passively degrade a single energy layer using a patient-specific range modulator. We propose an innovative method to directly optimize the geometrical…
In concurrent chemoradiotherapy, chemotherapeutic agents are administered during the course of radiotherapy to enhance the primary tumor control. However, that often comes at the expense of increased risk of normal-tissue complications. The…
Purpose: To quantitatively compare the dosimetric and biologic differences in treatment plans from flattened and flattening-filter-free (FFF) beam for three anatomic cancer sites. Methods and Materials: Treatment plans with static…
Diffusing alpha-emitters Radiation Therapy (Alpha DaRT) enables the use of alpha particles for the treatment of solid tumors. It employs interstitial sources carrying a few uCi of Ra-224, designed to release its short-lived progeny, which…
Computed tomography (CT) involves a patient's exposure to ionizing radiation. To reduce the radiation dose, we can either lower the X-ray photon count or down-sample projection views. However, either of the ways often compromises image…
Clinical applications of FLASH radiotherapy require formulas to describe how the FLASH radiation features and other related factors determine the FLASH effect. Mathematical analysis of the models can connect the theoretical hypotheses with…
Charged Particle Therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbons. A critical issue is the monitoring of the dose released by the beam to the tumor and to the surrounding tissues. We present…
Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation. The dose conformity of this treatment modality may be further improved if narrower proton…
The primary objective of Phase I oncology trials is to assess the safety and tolerability of novel therapeutics. Conventional dose escalation methods identify the maximum tolerated dose (MTD) based on dose-limiting toxicity (DLT). However,…