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Cancer subtype classification is crucial for personalized treatment and prognostic assessment. However, effectively integrating multi-omic data remains challenging due to the heterogeneous nature of genomic, epigenomic, and transcriptomic…

Machine Learning · Computer Science 2025-06-10 Sajib Acharjee Dip , Uddip Acharjee Shuvo , Dipanwita Mallick , Abrar Rahman Abir , Liqing Zhang

Recent advancements in general-purpose or domain-specific multimodal large language models (LLMs) have witnessed remarkable progress for medical decision-making. However, they are designated for specific classification or generative tasks,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Songtao Jiang , Tuo Zheng , Yan Zhang , Yeying Jin , Li Yuan , Zuozhu Liu

Comparison of optimization algorithms for inverse treatment planning requires objective function value evaluation.

Medical Physics · Physics 2015-03-17 Bram L. Gorissen , Aswin L. Hoffmann

We review the field of multi-criteria optimization for radiation therapy treatment planning. Special attention is given to the technique known as Pareto surface navigation, which allows physicians and treatment planners to interactively…

Optimization and Control · Mathematics 2013-05-08 David Craft

The processes occurring in climatic change evolution and their variations play a major role in environmental engineering. Different techniques are used to model the relationship between temperatures, dew point and relative humidity. Gene…

Neural and Evolutionary Computing · Computer Science 2013-04-19 Siddharth Shroff , Vipul Dabhi

Solving constrained multi-objective optimization problems with evolutionary algorithms has attracted considerable attention. Various constrained multi-objective optimization evolutionary algorithms (CMOEAs) have been developed with the use…

Artificial Intelligence · Computer Science 2024-02-21 Fei Ming , Wenyin Gong , Ling Wang , Yaochu Jin

Optimum implementation of non-conventional wells allows us to increase considerably hydrocarbon recovery. By considering the high drilling cost and the potential improvement in well productivity, well placement decision is an important…

Computational Engineering, Finance, and Science · Computer Science 2010-11-25 Zyed Bouzarkouna , Didier Yu Ding , Anne Auger

A preference based multi-objective evolutionary algorithm is proposed for generating solutions in an automatically detected knee point region. It is named Automatic Preference based DI-MOEA (AP-DI-MOEA) where DI-MOEA stands for…

Neural and Evolutionary Computing · Computer Science 2021-01-26 Yali Wang , Steffen Limmer , Markus Olhofer , Michael Emmerich , Thomas Baeck

We design a class of variable metric evolution strategies well suited for high-dimensional problems. We target problems with many variables, not (necessarily) with many objectives. The construction combines two independent developments:…

Neural and Evolutionary Computing · Computer Science 2024-12-23 Tobias Glasmachers

The optimization problems in realistic world present significant challenges onto optimization algorithms, such as the expensive evaluation issue and complex constraint conditions. COBRA optimizer (including its up-to-date variants) is a…

Neural and Evolutionary Computing · Computer Science 2026-02-03 Zipei Yu , Zhiyang Huang , Hongshu Guo , Yue-Jiao Gong , Zeyuan Ma

The performance of evolutionary algorithms can be heavily undermined when constraints limit the feasible areas of the search space. For instance, while Covariance Matrix Adaptation Evolution Strategy is one of the most efficient algorithms…

Neural and Evolutionary Computing · Computer Science 2018-10-08 A. Maesani , G. Iacca , D. Floreano

We consider multiobjective combinatorial optimization problems handled by means of preference driven efficient heuristics. They look for the most preferred part of the Pareto front on the basis of some preferences expressed by the Decision…

Optimization and Control · Mathematics 2022-03-09 Maria Barbati , Salvatore Corrente , Salvatore Greco

An emerging optimisation problem from the real-world applications, named the multi-point dynamic aggregation (MPDA) problem, has become one of the active research topics of the multi-robot system. This paper focuses on a multi-objective…

Neural and Evolutionary Computing · Computer Science 2021-05-12 Guanqiang Gao , Bin Xin , Yi Mei , Shuxin Ding , Juan Li

This study focuses on mixed-variable black-box optimization (MV-BBO), addressing continuous, integer, and categorical variables. Many real-world MV-BBO problems involve dependencies among these different types of variables, requiring…

Neural and Evolutionary Computing · Computer Science 2026-01-08 Ryoki Hamano , Masahiro Nomura , Shota Saito , Kento Uchida , Shinichi Shirakawa

We propose a prognostic stratum matching framework that addresses the deficiencies of Randomized trial data subgroup analysis and transforms ObservAtional Data to be used as if they were randomized, thus paving the road for precision…

Applications · Statistics 2023-11-06 Dimitris Bertsimas , Angelos G. Koulouras , Georgios Antonios Margonis

Variable selection is recognized as one of the most critical steps in statistical modeling. The problems encountered in engineering and social sciences are commonly characterized by over-abundance of explanatory variables, non-linearities…

Computation · Statistics 2016-07-14 Ankur Sinha , Pekka Malo , Timo Kuosmanen

This paper presents the Multi-Objective Ant Nesting Algorithm (MOANA), a novel extension of the Ant Nesting Algorithm (ANA), specifically designed to address multi-objective optimization problems (MOPs). MOANA incorporates adaptive…

Neural and Evolutionary Computing · Computer Science 2024-11-26 Noor A. Rashed , Yossra H. Ali Tarik A. Rashid , Seyedali Mirjalili

In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain…

Computer Vision and Pattern Recognition · Computer Science 2018-08-17 Mikael Agn , Per Munck af Rosenschöld , Oula Puonti , Michael J. Lundemann , Laura Mancini , Anastasia Papadaki , Steffi Thust , John Ashburner , Ian Law , Koen Van Leemput

Evolutionary algorithms often struggle to find well converged (e.g small inverted generational distance on test problems) solutions to multi-objective optimization problems on a limited budget of function evaluations (here, a few hundred).…

Neural and Evolutionary Computing · Computer Science 2025-04-30 Christopher M. Pierce , Young-Kee Kim , Ivan Bazarov

Real-world multiobjective optimization problems usually involve conflicting objectives that change over time, which requires the optimization algorithms to quickly track the Pareto optimal front (POF) when the environment changes. In recent…

Neural and Evolutionary Computing · Computer Science 2021-02-25 Dejun Xu , Min Jiang , Weizhen Hu , Shaozi Li , Renhu Pan , Gary G. Yen