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Developing models with high interpretability and even deriving formulas to quantify relationships between biological data is an emerging need. We propose here a framework for ab initio derivation of sequence motifs and linear formula using…

Quantitative Methods · Quantitative Biology 2022-08-23 Chengyu Liu , Wei Wang

In this paper we introduce a novel framework for making exact nonparametric Bayesian inference on latent functions, that is particularly suitable for Big Data tasks. Firstly, we introduce a class of stochastic processes we refer to as…

Machine Learning · Statistics 2016-08-22 Yves-Laurent Kom Samo , Stephen Roberts

Graph Neural Networks (GNNs) have become essential in interpreting relational data across various domains, yet, they often struggle to generalize to unseen graph data that differs markedly from training instances. In this paper, we…

Machine Learning · Computer Science 2024-12-10 Xinke Jiang , Rihong Qiu , Yongxin Xu , Wentao Zhang , Yichen Zhu , Ruizhe Zhang , Yuchen Fang , Xu Chu , Junfeng Zhao , Yasha Wang

In this paper, we propose an algorithmic framework to automatically generate efficient deep neural networks and optimize their associated hyperparameters. The framework is based on evolving directed acyclic graphs (DAGs), defining a more…

Neural and Evolutionary Computing · Computer Science 2024-05-15 Julie Keisler , El-Ghazali Talbi , Sandra Claudel , Gilles Cabriel

We propose and study a method for learning interpretable representations for the task of regression. Features are represented as networks of multi-type expression trees comprised of activation functions common in neural networks in addition…

Neural and Evolutionary Computing · Computer Science 2019-03-26 William La Cava , Tilak Raj Singh , James Taggart , Srinivas Suri , Jason H. Moore

This paper proposes a hybrid basis function construction method (GP-RVM) for Symbolic Regression problem, which combines an extended version of Genetic Programming called Kaizen Programming and Relevance Vector Machine to evolve an optimal…

Neural and Evolutionary Computing · Computer Science 2018-08-28 Hossein Izadi Rad , Ji Feng , Hitoshi Iba

Genetic programming (GP) is an evolutionary computation technique to solve problems in an automated, domain-independent way. Rather than identifying the optimum of a function as in more traditional evolutionary optimization, the aim of GP…

Neural and Evolutionary Computing · Computer Science 2019-05-15 Andrei Lissovoi , Pietro S. Oliveto

Cartesian Genetic Programming has traditionally been using mutation as its main and often sole genetic operator to drive evolutionary search. Despite advancements in recent years, recombinationbased approaches have long been avoided, due to…

Neural and Evolutionary Computing · Computer Science 2026-05-28 Duy Long Tran , Anja Jankovic , Marie Anastacio , Holger Hoos , Roman Kalkreuth

Evolutionary deep neural networks have emerged as a rapidly growing field of research. This paper studies numerical integrators for such and other classes of nonlinear parametrizations $ u(t) = \Phi(\theta(t)) $, where the evolving…

Numerical Analysis · Mathematics 2025-01-22 Christian Lubich , Jörg Nick

Genetic programming (GP) has the potential to generate explainable results, especially when used for dimensionality reduction. In this research, we investigate the potential of leveraging eXplainable AI (XAI) and large language models…

Neural and Evolutionary Computing · Computer Science 2024-03-07 Paula Maddigan , Andrew Lensen , Bing Xue

Gene regulatory networks (GRNs) control cellular function and decision making during tissue development and homeostasis. Mathematical tools based on dynamical systems theory are often used to model these networks, but the size and…

Molecular Networks · Quantitative Biology 2018-03-16 Edgar Herrera-Delgado , Ruben Perez-Carrasco , James Briscoe , Peter Sollich

Discovering the governing equations of dynamical systems is a central problem across many scientific disciplines. As experimental data become increasingly available, automated equation discovery methods offer a promising data-driven…

Machine Learning · Computer Science 2026-04-07 Amirmohammad Ziaei Bideh , Jonathan Gryak

Many machine learning strategies designed to automate mathematical tasks leverage neural networks to search large combinatorial spaces of mathematical symbols. In contrast to traditional evolutionary approaches, using a neural network at…

Symbolic Regression (SR) can generate interpretable, concise expressions that fit a given dataset, allowing for more human understanding of the structure than black-box approaches. The addition of background knowledge (in the form of…

Machine Learning · Computer Science 2023-05-05 Charles Fox , Neil Tran , Nikki Nacion , Samiha Sharlin , Tyler R. Josephson

Symbolic Regression (SR) is a regression method that aims to discover mathematical expressions that describe the relationship between variables, and it is often implemented through Genetic Programming, a metaphor for the process of…

Neural and Evolutionary Computing · Computer Science 2025-12-02 Guilherme Seidyo Imai Aldeia

Omics data, such as transcriptomics, proteomics, and metabolomics, provide critical insights into disease mechanisms and clinical outcomes. However, their high dimensionality, small sample sizes, and intricate biological networks pose major…

Machine Learning · Computer Science 2026-01-22 Tiantian Yang , Yuxuan Wang , Zhenwei Zhou , Ching-Ti Liu

Identifying the mathematical relationships that best describe a dataset remains a very challenging problem in machine learning, and is known as Symbolic Regression (SR). In contrast to neural networks which are often treated as black boxes,…

Machine Learning · Computer Science 2023-01-10 Tony Tohme , Dehong Liu , Kamal Youcef-Toumi

Understanding how complex systems respond to perturbations, such as whether they will remain stable or what their most sensitive patterns are, is a fundamental challenge across science and engineering. Traditional stability and receptivity…

Fluid Dynamics · Physics 2026-04-28 Chengyun Wang , Liwei Chen , Nils Thuerey

Logic-Geometric Programming (LGP) is a powerful motion and manipulation planning framework, which represents hierarchical structure using logic rules that describe discrete aspects of problems, e.g., touch, grasp, hit, or push, and solves…

Robotics · Computer Science 2020-03-10 Jung-Su Ha , Danny Driess , Marc Toussaint

We introduce SymbolFit, a framework that automates parametric modeling by using symbolic regression to perform a machine-search for functions that fit the data while simultaneously providing uncertainty estimates in a single run.…

High Energy Physics - Experiment · Physics 2025-07-04 Ho Fung Tsoi , Dylan Rankin , Cecile Caillol , Miles Cranmer , Sridhara Dasu , Javier Duarte , Philip Harris , Elliot Lipeles , Vladimir Loncar