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Nuclei detection is a key task in Ki67 proliferation index estimation in breast cancer images. Deep learning algorithms have shown strong potential in nuclei detection tasks. However, they face challenges when applied to pathology images…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Seyed Hossein Mirjahanmardi , Melanie Dawe , Anthony Fyles , Wei Shi , Fei-Fei Liu , Susan Done , April Khademi

The nuclear protein Ki-67 and Tumor infiltrating lymphocytes (TILs) have been introduced as prognostic factors in predicting tumor progression and its treatment response. The value of the Ki-67 index and TILs in approach to heterogeneous…

Image and Video Processing · Electrical Eng. & Systems 2021-04-30 Farzin Negahbani , Rasool Sabzi , Bita Pakniyat Jahromi , Fateme Movahedi , Mahsa Kohandel Shirazi , Shayan Majidi , Dena Firouzabadi , Amirreza Dehghanian

Ki67 is an important biomarker for breast cancer. Classification of positive and negative Ki67 cells in histology slides is a common approach to determine cancer proliferation status. However, there is a lack of generalizable and accurate…

Computer Vision and Pattern Recognition · Computer Science 2018-06-29 Priya Lakshmi Narayanan , Shan E Ahmed Raza , Andrew Dodson , Barry Gusterson , Mitchell Dowsett , Yinyin Yuan

Ki-67 is a nuclear protein that can be produced during cell proliferation. The Ki67 index is a valuable prognostic variable in several kinds of cancer. In breast cancer, the index is even routinely checked in many patients. Currently,…

Image and Video Processing · Electrical Eng. & Systems 2022-09-28 Hsiang-Wei Huang , Wen-Tsung Huang , Hsun-Heng Tsai

Reliable quantification of Ki-67, a key proliferation marker in breast cancer, is essential for molecular subtyping and informed treatment planning. Conventional approaches, including visual estimation and manual counting, suffer from…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Deepti Madurai Muthu , Priyanka S , Lalitha Rani N , P. G. Kubendran Amos

Breast cancer has become a symbol of tremendous concern in the modern world, as it is one of the major causes of cancer mortality worldwide. In this regard, breast ultrasonography images are frequently utilized by doctors to diagnose breast…

Image and Video Processing · Electrical Eng. & Systems 2022-02-15 Muhammad Sakib Khan Inan , Fahim Irfan Alam , Rizwan Hasan

Clear cell renal cell carcinoma (ccRCC) is one of the most common forms of intratumoral heterogeneity in the study of renal cancer. ccRCC originates from the epithelial lining of proximal convoluted renal tubules. These cells undergo…

Image and Video Processing · Electrical Eng. & Systems 2021-07-02 Shiba Kuanar , Vassilis Athitsos , Dwarikanath Mahapatra , Anand Rajan

The prediction of tumor progression and chemotherapy response has been recently tackled exploiting Tumor Infiltrating Lymphocytes (TILs) and the nuclear protein Ki67 as prognostic factors. Recently, deep neural networks (DNNs) have been…

Quantitative Methods · Quantitative Biology 2024-01-02 J. Gliozzo , G. Marinò , A. Bonometti , M. Frasca , D. Malchiodi

In this paper, we introduce PathRTM, a novel deep neural network detector based on RTMDet, for automated KI-67 proliferation and tumor-infiltrated lymphocyte estimation. KI-67 proliferation and tumor-infiltrated lymphocyte estimation play a…

Quantitative Methods · Quantitative Biology 2023-05-03 Steven Zvi Lapp , Eli David , Nathan S. Netanyahu

Current analysis of tumor proliferation, the most salient prognostic biomarker for invasive breast cancer, is limited to subjective mitosis counting by pathologists in localized regions of tissue images. This study presents the first…

Computer Vision and Pattern Recognition · Computer Science 2016-10-12 Manan Shah , Christopher Rubadue , David Suster , Dayong Wang

We address the problem of supporting radiologists in the longitudinal management of lung cancer. Therefore, we proposed a deep learning pipeline, composed of four stages that completely automatized from the detection of nodules to the…

Image and Video Processing · Electrical Eng. & Systems 2021-03-29 Xavier Rafael-Palou , Anton Aubanell , Mario Ceresa , Vicent Ribas , Gemma Piella , Miguel A. González Ballester

Automated cervical nucleus segmentation based on deep learning can effectively improve the quantitative analysis of cervical cancer. However, accurate nuclei segmentation is still challenging. The classic U-net has not achieved satisfactory…

Image and Video Processing · Electrical Eng. & Systems 2019-11-13 Jie Zhao , Lei Dai , Mo Zhang , Fei Yu , Meng Li , Hongfeng Li , Wenjia Wang , Li Zhang

An automatic segmentation algorithm for delineation of the gross tumour volume and pathologic lymph nodes of head and neck cancers in PET/CT images is described. The proposed algorithm is based on a convolutional neural network using the…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Yngve Mardal Moe , Aurora Rosvoll Groendahl , Martine Mulstad , Oliver Tomic , Ulf Indahl , Einar Dale , Eirik Malinen , Cecilia Marie Futsaether

Background: Skin cancer is one of the widely seen cancer worldwide and automatic classification of skin cancer can be benefited dermatology clinics for an accurate diagnosis. Hence, a machine learning-based automatic skin cancer detection…

Computer Vision and Pattern Recognition · Computer Science 2022-03-30 Mehmet Baygin , Turker Tuncer , Sengul Dogan

Accurately assessing tumor removal is paramount in the management of glioblastoma. We developed a pipeline using MRI scans and neural networks to segment tumor subregions and the surgical cavity in postoperative images. Our model excels in…

Precise characterization of the kidney and kidney tumor characteristics is of outmost importance in the context of kidney cancer treatment, especially for nephron sparing surgery which requires a precise localization of the tissues to be…

Image and Video Processing · Electrical Eng. & Systems 2020-11-03 Gianmarco Santini , Noémie Moreau , Mathieu Rubeaux

Oral cancer incidence is rapidly increasing worldwide. The most important determinant factor in cancer survival is early diagnosis. To facilitate large scale screening, we propose a fully automated pipeline for oral cancer detection on…

Image and Video Processing · Electrical Eng. & Systems 2020-09-14 Jiahao Lu , Nataša Sladoje , Christina Runow Stark , Eva Darai Ramqvist , Jan-Michaél Hirsch , Joakim Lindblad

The quantification of biomarkers on immunohistochemistry breast cancer images is essential for defining appropriate therapy for breast cancer patients, as well as for extracting relevant information on disease prognosis. This is an arduous…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Blanca Maria Priego-Torresa , Barbara Lobato-Delgado , Lidia Atienza-Cuevas , Daniel Sanchez-Morillo

Tumour-infiltrating lymphocytes (TILs) are considered as a valuable prognostic markers in both triple-negative and human epidermal growth factor receptor 2 (HER2) positive breast cancer. In this study, we introduce an innovative deep…

Image and Video Processing · Electrical Eng. & Systems 2023-11-22 Adam J Shephard , Mostafa Jahanifar , Ruoyu Wang , Muhammad Dawood , Simon Graham , Kastytis Sidlauskas , Syed Ali Khurram , Nasir M Rajpoot , Shan E Ahmed Raza

In this paper, we introduce a conceptually simple network for generating discriminative tissue-level segmentation masks for the purpose of breast cancer diagnosis. Our method efficiently segments different types of tissues in breast biopsy…

Computer Vision and Pattern Recognition · Computer Science 2018-06-06 Sachin Mehta , Ezgi Mercan , Jamen Bartlett , Donald Weave , Joann G. Elmore , Linda Shapiro
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