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The recent spike in certified Artificial Intelligence (AI) tools for healthcare has renewed the debate around adoption of this technology. One thread of such debate concerns Explainable AI (XAI) and its promise to render AI devices more…

Artificial Intelligence · Computer Science 2023-02-27 Giovanni Cinà , Tabea E. Röber , Rob Goedhart , Ş. İlker Birbil

Multiple instance learning (MIL) has enabled substantial progress in computational histopathology, where a large amount of patches from gigapixel whole slide images are aggregated into slide-level predictions. Heatmaps are widely used to…

Validation metrics are key for the reliable tracking of scientific progress and for bridging the current chasm between artificial intelligence (AI) research and its translation into practice. However, increasing evidence shows that…

Artificial Intelligence in Medicine has made significant progress with emerging applications in medical imaging, patient care, and other areas. While these applications have proven successful in retrospective studies, very few of them were…

Artificial Intelligence · Computer Science 2023-08-11 Nicoletta Prentzas , Antonis Kakas , Constantinos S. Pattichis

Artificial Intelligence (AI) has become essential for analyzing complex data and solving highly-challenging tasks. It is being applied across numerous disciplines beyond computer science, including Food Engineering, where there is a growing…

As artificial intelligence becomes increasingly pervasive and powerful, the ability to audit AI-based systems is growing in importance. However, explainability for artificial intelligence systems is not a one-size-fits-all solution;…

Human-Computer Interaction · Computer Science 2025-10-13 Nicola Rossberg , Bennett Kleinberg , Barry O'Sullivan , Luca Longo , Andrea Visentin

Clinical decision making from magnetic resonance imaging (MRI) combines complementary information from multiple MRI sequences (defined as 'modalities'). MRI image registration aims to geometrically 'pair' diagnoses from different…

Image and Video Processing · Electrical Eng. & Systems 2023-08-07 Chengjia Wang , Giorgos Papanastasiou

Despite promising developments in Explainable Artificial Intelligence, the practical value of XAI methods remains under-explored and insufficiently validated in real-world settings. Robust and context-aware evaluation is essential, not only…

Human-Computer Interaction · Computer Science 2025-06-18 Ivania Donoso-Guzmán , Kristýna Sirka Kacafírková , Maxwell Szymanski , An Jacobs , Denis Parra , Katrien Verbert

In the health domain, decisions are often based on different data modalities. Thus, when creating prediction models, multimodal fusion approaches that can extract and combine relevant features from different data modalities, can be highly…

Artificial Intelligence · Computer Science 2024-02-20 Mafalda Malafaia , Thalea Schlender , Peter A. N. Bosman , Tanja Alderliesten

XAI refers to the techniques and methods for building AI applications which assist end users to interpret output and predictions of AI models. Black box AI applications in high-stakes decision-making situations, such as medical domain have…

Explainable Artificial Intelligence (XAI) is essential for the transparency and clinical adoption of Clinical Decision Support Systems (CDSS). However, the real-world effectiveness of existing XAI methods remains limited and is…

Machine Learning · Computer Science 2026-01-26 Alessandro Gambetti , Qiwei Han , Hong Shen , Claudia Soares

A multitude of explainability methods and associated fidelity performance metrics have been proposed to help better understand how modern AI systems make decisions. However, much of the current work has remained theoretical -- without much…

Computer Vision and Pattern Recognition · Computer Science 2023-02-01 Julien Colin , Thomas Fel , Remi Cadene , Thomas Serre

Advances in computing power, deep learning architectures, and expert labelled datasets have spurred the development of medical imaging artificial intelligence systems that rival clinical experts in a variety of scenarios. The National…

Image and Video Processing · Electrical Eng. & Systems 2021-11-18 Rohan Shad , John P. Cunningham , Euan A. Ashley , Curtis P. Langlotz , William Hiesinger

Explainable AI aims to render model behavior understandable by humans, which can be seen as an intermediate step in extracting causal relations from correlative patterns. Due to the high risk of possible fatal decisions in image-based…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Lukas Klein , João B. S. Carvalho , Mennatallah El-Assady , Paolo Penna , Joachim M. Buhmann , Paul F. Jaeger

Given the sheer volume of surgical procedures and the significant rate of postoperative fatalities, assessing and managing surgical complications has become a critical public health concern. Existing artificial intelligence (AI) tools for…

Pretraining on large-scale, in-domain datasets grants histopathology foundation models (FM) the ability to learn task-agnostic data representations, enhancing transfer learning on downstream tasks. In computational pathology, automated…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Pablo Meseguer , Rocío del Amor , Valery Naranjo

One principal impediment in the successful deployment of AI-based Computer-Aided Diagnosis (CAD) systems in clinical workflows is their lack of transparent decision making. Although commonly used eXplainable AI methods provide some insight…

Artificial Intelligence · Computer Science 2022-01-05 Adriano Lucieri , Muhammad Naseer Bajwa , Stephan Alexander Braun , Muhammad Imran Malik , Andreas Dengel , Sheraz Ahmed

Explainable AI (XAI) promises to provide insight into machine learning models' decision processes, where one goal is to identify failures such as shortcut learning. This promise relies on the field's assumption that input features marked as…

Machine Learning · Computer Science 2026-02-19 Benedict Clark , Marta Oliveira , Rick Wilming , Stefan Haufe

Clinical decision-making relies on the integrated analysis of medical images and the associated clinical reports. While Vision-Language Models (VLMs) can offer a unified framework for such tasks, they can exhibit strong biases toward one…

Computer Vision and Pattern Recognition · Computer Science 2025-08-04 David Restrepo , Ira Ktena , Maria Vakalopoulou , Stergios Christodoulidis , Enzo Ferrante

eXplainable Artificial Intelligence (XAI) is a sub-field of Artificial Intelligence (AI) that is at the forefront of AI research. In XAI, feature attribution methods produce explanations in the form of feature importance. People often use…

Artificial Intelligence · Computer Science 2022-02-09 Jamie Duell , Monika Seisenberger , Gert Aarts , Shangming Zhou , Xiuyi Fan