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Cell biologists study in parallel the morphology of cells with the regulation mechanisms that modify this morphology. Such studies are complicated by the inherent heterogeneity present in the cell population. It remains difficult to define…

Quantitative Methods · Quantitative Biology 2025-12-23 Yossi Bokor Bleile , Pooja Yadav , Patrice Koehl , Florian Rehfeldt

Topological Data Analysis is a relatively new field of study that uses topological invariants to study the shape of data. We analyze a dataset provided by the Centers for Disease Control and Prevention (CDC) using persistent homology and…

Algebraic Topology · Mathematics 2025-10-20 Megan Fairchild , Matthew Lemoine

We develop a method for analyzing spatial and spatiotemporal anomalies in geospatial data using topological data analysis (TDA). To do this, we use persistent homology (PH), which allows one to algorithmically detect geometric voids in a…

Physics and Society · Physics 2022-03-01 Abigail Hickok , Deanna Needell , Mason A. Porter

Persistent Homology is a powerful tool in Topological Data Analysis (TDA) to capture topological properties of data succinctly at different spatial resolutions. For graphical data, shape, and structure of the neighborhood of individual data…

Social and Information Networks · Computer Science 2018-11-12 Sumit Bhatia , Bapi Chatterjee , Deepak Nathani , Manohar Kaul

Convolutional neural networks (CNNs) are a standard tool for computer vision tasks such as image classification. However, typical model architectures may result in the loss of topological information. In specific domains such as…

Image and Video Processing · Electrical Eng. & Systems 2026-03-05 Shrunal Pothagoni , Benjamin Schweinhart

This article studies the robust version of persistent homology based on trimming methodology to capture the geometric feature through support of the data in presence of outliers. Precisely speaking, the proposed methodology works when the…

Methodology · Statistics 2026-01-01 Tuhin Subhra Mahato , Subhra Sankar Dhar

Topological data analysis is an approach to study shape of a data set by means of topology. Its main object of study is the persistence diagram, which represents the topological features of the data set at different spatial resolutions.…

Algebraic Topology · Mathematics 2025-11-05 Azmeer Nordin , Mohd Salmi Md Noorani , Nurulkamal Masseran , Mohd Sabri Ismail , Nur Firyal Roslan

Topological data analysis (TDA), while abstract, allows a characterization of time-series data obtained from nonlinear and complex dynamical systems. Though it is surprising that such an abstract measure of structure - counting pieces and…

Computational Geometry · Computer Science 2020-01-07 Nicole Sanderson , Elliott Shugerman , Samantha Molnar , James D. Meiss , Elizabeth Bradley

Chest computed tomography (CT) has played an essential diagnostic role in assessing patients with COVID-19 by showing disease-specific image features such as ground-glass opacity and consolidation. Image segmentation methods have proven to…

Image and Video Processing · Electrical Eng. & Systems 2021-07-26 Seong Tae Kim , Leili Goli , Magdalini Paschali , Ashkan Khakzar , Matthias Keicher , Tobias Czempiel , Egon Burian , Rickmer Braren , Nassir Navab , Thomas Wendler

Countries are recording health information on the global spread of COVID-19 using different methods, sometimes changing the rules after a few days. They are all publishing the number of new individuals infected, cured and dead, along with…

Populations and Evolution · Quantitative Biology 2020-12-15 J. M. Calabuig , L. M. García-Raffi , A. García-Valiente , E. A. Sánchez-Pérez

Gait recognition is an important biometric technique for video surveillance tasks, due to the advantage of using it at distance. In this paper, we present a persistent homology-based method to extract topological features (the so-called…

Computer Vision and Pattern Recognition · Computer Science 2017-07-24 J. Lamar-Leon , Raul Alonso-Baryolo , Edel Garcia-Reyes , R. Gonzalez-Diaz

Accurate and interpretable brain tumor classification from medical imaging remains a challenging problem due to the high dimensionality and complex structural patterns present in magnetic resonance imaging (MRI). In this study, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Faisal Ahmed

Introduction: For COVID-19 patients accurate prediction of disease severity and mortality risk would greatly improve care delivery and resource allocation. There are many patient-related factors, such as pre-existing comorbidities that…

X-ray images may present non-trivial features with predictive information of patients that develop severe symptoms of COVID-19. If true, this hypothesis may have practical value in allocating resources to particular patients while using a…

Image and Video Processing · Electrical Eng. & Systems 2021-01-22 Douglas P. S. Gomes , Anwaar Ulhaq , Manoranjan Paul , Michael J. Horry , Subrata Chakraborty , Manas Saha , Tanmoy Debnath , D. M. Motiur Rahaman

Topological Data Analysis (TDA) is an approach to handle with big data by studying its shape. A main tool of TDA is the persistence diagram, and one can use it to compare data sets. One approach to learn on the similarity between two…

Applications · Statistics 2020-03-04 Sarit Agami

Single-parameter persistent homology, a key tool in topological data analysis, has been widely applied to data problems along with statistical techniques that quantify the significance of the results. In contrast, statistical techniques for…

Algebraic Topology · Mathematics 2020-12-14 Matthew Wright , Xiaojun Zheng

We characterize structures such as monotonicity, convexity, and modality in smooth regression curves using persistent homology. Persistent homology is a key tool in topological data analysis that detects higher-dimensional topological…

Algebraic Topology · Mathematics 2025-10-28 Satish Kumar , Subhra Sankar Dhar

Visualization in the emerging field of topological data analysis has progressed from persistence barcodes and persistence diagrams to display of two-parameter persistent homology. Although persistence barcodes and diagrams have permitted…

Applications · Statistics 2019-01-08 Raoul R. Wadhwa , Andrew Dhawan , Drew F. K. Williamson , Jacob G. Scott

Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides…

Quantitative Methods · Quantitative Biology 2025-05-06 Maria Torras-Pérez , Iris H. R. Yoon , Praveen Weeratunga , Ling-Pei Ho , Helen M. Byrne , Ulrike Tillmann , Heather A. Harrington

Persistent homology is a common technique in topological data analysis providing geometrical and topological information about the sample space. All this information, known as topological features, is summarized in persistence diagrams, and…

Methodology · Statistics 2022-04-05 Asael Fabian Martínez