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Related papers: Functional universality in slow-growing microbial …

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High-throughput experimental techniques and bioinformatics tools make it possible to obtain reconstructions of the metabolism of microbial species. Combined with mathematical frameworks such as flux balance analysis, which assumes that…

Microbial communities routinely have several alternative stable states observed for the same environmental parameters. Sudden and irreversible transitions between these states make external manipulation of these systems more complicated. To…

Populations and Evolution · Quantitative Biology 2018-10-12 Veronika Dubinkina , Yulia Fridman , Parth Pandey , Sergei Maslov

The metabolic network plays a crucial role in regulating bacterial metabolism and growth, but it is subject to inherent molecular stochasticity. Previous studies have utilized flux balance analysis and the maximum entropy method to predict…

Molecular Networks · Quantitative Biology 2024-01-12 Shaohua Guan , Zhichao Zhang , Zihan Zhang , Hualin Shi

The energy dissipated by a living organism is commonly identified with heat generation. However, as cells exchange metabolites with their environment they also dissipate energy in the form of chemical entropy. How dissipation is distributed…

Other Quantitative Biology · Quantitative Biology 2025-10-09 Tommaso Cossetto , Jonathan Rodenfels , Pablo Sartori

Ecosystems frequently display the coexistence of diverse species under resource competition, typically resulting in skewed distributions of rarity and abundance. A potential driver of such coexistence is environmental fluctuations that…

Populations and Evolution · Quantitative Biology 2025-08-07 Davide Zanchetta , Deepak Gupta , Sofia Moschin , Samir Suweis , Amos Maritan , Sandro Azaele

Microbial communities assemble through a complex set of interactions between microbes and their environment, and the resulting metabolic impact on the host ecosystem can be profound. Microbial activity is known to impact human health, plant…

Quantitative Methods · Quantitative Biology 2023-11-09 James D. Brunner , Laverne A. Gallegos-Graves , Marie E. Kroeger

Our planet is roughly closed to matter, but open to energy input from the sun. However, to harness this energy, organisms must transform matter from one chemical (redox) state to another. For example, photosynthetic organisms can capture…

Populations and Evolution · Quantitative Biology 2024-03-04 Akshit Goyal , Avi I. Flamholz , Alexander P. Petroff , Arvind Murugan

Immotile microbes inhabit nearly every environment on Earth, from soils and sediments to food matrices -- yet how they disperse through these physically confining environments is poorly understood. Here, we show that immotile microbial…

The human gut microbiome is a complex ecosystem, in which hundreds of microbial species and metabolites coexist, in part due to an extensive network of cross-feeding interactions. However, both the large-scale trophic organization of this…

Populations and Evolution · Quantitative Biology 2020-07-01 Tong Wang , Akshit Goyal , Veronika Dubinkina , Sergei Maslov

We introduce an approach to partitioning networks into communities that not only determines the best community structure, but also provides a range of characterization techniques to assess how significant that structure is. We study the…

Statistical Mechanics · Physics 2007-05-23 Claire P. Massen , Jonathan P. K. Doye

In this work we to develop a general statistical mechanic formalism to study systems restricted to surfaces of revolution, these are a very well model to study the termodinamical properties of microbiological systems and macromolecules lies…

Soft Condensed Matter · Physics 2013-08-27 J. L. Silva-Acosta , R. Juárez-Maldonado

There is a pressing need to better understand how microbial populations respond to antimicrobial drugs, and to find mechanisms to possibly eradicate antimicrobial-resistant cells. The inactivation of antimicrobials by resistant microbes can…

Populations and Evolution · Quantitative Biology 2023-11-16 Lluís Hernández-Navarro , Matthew Asker , Alastair M. Rucklidge , Mauro Mobilia

In living systems, collective molecular behavior is driven by thermodynamic forces in the form of chemical gradients. Leveraging recent advances in the field of nonequilibrium physics, I show that increasing the thermodynamic force alone…

Subcellular Processes · Quantitative Biology 2022-09-21 Milo M. Lin

Standard game theory cannot describe microbial interactions mediated by diffusible molecules. Nevertheless, we show that one can still model microbial dynamics using game theory with parameters renormalized by diffusion. Contrary to…

Populations and Evolution · Quantitative Biology 2015-05-26 Rajita Menon , Kirill S. Korolev

This study investigates the role of spatial segregation, prompted by competition avoidance, as a key mechanism for emergent coexistence within microbial communities. Recognizing these communities as complex adaptive systems, we challenge…

Physics and Society · Physics 2024-03-12 Mattia Mattei , Alex Arenas

Microbial communities display extreme diversity. A variety of strains or species coexist even when limited by a single resource. It has been argued that metabolite secretion creates new niches and facilitates such diversity. Nonetheless, it…

Populations and Evolution · Quantitative Biology 2020-02-05 Jumpei F Yamagishi , Nen Saito , Kunihiko Kaneko

Microbial communities are ubiquitous in nature and come in a multitude of forms, ranging from communities dominated by a handful of species to communities containing a wide variety of metabolically distinct organisms. This huge range in…

Biological Physics · Physics 2021-11-02 Amir Erez , Jaime G. Lopez , Yigal Meir , Ned S. Wingreen

A key unresolved question in microbial ecology is how the extraordinary diversity of microbiomes emerges from the behaviour of individual populations. This process is driven by the cross-feeding networks that structure these communities,…

Populations and Evolution · Quantitative Biology 2026-04-09 Tom Clegg , Thilo gross

Monod's law is a widely accepted phenomenology for bacterial growth. Since it has the same functional form as the Michaelis--Menten equation for enzyme kinetics, cell growth is often considered to be locally constrained by a single…

Cell Behavior · Quantitative Biology 2025-10-14 Jumpei F. Yamagishi , Tetsuhiro S. Hatakeyama

This paper presents a conceptual model describing the medium and long-term co-evolution of natural and socio-economic subsystems of Earth. An economy is viewed as an out-of-equilibrium dissipative structure that can only be maintained with…

General Economics · Economics 2022-05-09 Éric Herbert , and Gael Giraud , Aurélie Louis-Napoléon , Christophe Goupil