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While energy-based models (EBMs) exhibit a number of desirable properties, training and sampling on high-dimensional datasets remains challenging. Inspired by recent progress on diffusion probabilistic models, we present a diffusion…

Machine Learning · Computer Science 2021-03-30 Ruiqi Gao , Yang Song , Ben Poole , Ying Nian Wu , Diederik P. Kingma

We propose a novel unsupervised out-of-distribution detection method for medical images based on implicit fields image representations. In our approach, an auto-decoder feed-forward neural network learns the distribution of healthy images…

Image and Video Processing · Electrical Eng. & Systems 2021-06-10 Sergio Naval Marimont , Giacomo Tarroni

Accurate 3D aortic construction is crucial for clinical diagnosis, preoperative planning, and computational fluid dynamics (CFD) simulations, as it enables the estimation of critical hemodynamic parameters such as blood flow velocity,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-21 Delin An , Pan Du , Jian-Xun Wang , Chaoli Wang

Diffusion models have emerged as effective distribution estimators in vision, language, and reinforcement learning, but their use as priors in downstream tasks poses an intractable posterior inference problem. This paper studies amortized…

We present a general framework for Bayesian estimation of incompletely observed multivariate diffusion processes. Observations are assumed to be discrete in time, noisy and incomplete. We assume the drift and diffusion coefficient depend on…

Methodology · Statistics 2019-02-04 Frank van der Meulen , Moritz Schauer

Stochastic variational inference for Bayesian deep neural network (DNN) requires specifying priors and approximate posterior distributions over neural network weights. Specifying meaningful weight priors is a challenging problem,…

Neural and Evolutionary Computing · Computer Science 2020-01-01 Ranganath Krishnan , Mahesh Subedar , Omesh Tickoo

The complex and dynamic real-world clinical environment demands reliable deep learning (DL) systems. Out-of-distribution (OOD) detection plays a critical role in enhancing the reliability and generalizability of DL models when encountering…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Jiangbei Yue , Darren Treanor , Venkataraman Subramanian , Sharib Ali

Automated multimodal depression estimation in unconstrained environments is inherently challenged by naturalistic noise and complex behavioral variability. Prevailing deterministic methods, however, produce uncalibrated point estimates…

Machine Learning · Computer Science 2026-05-11 Fangyuan Liu , Sirui Zhao , Zeyu Zhang , Jinyang Huang , Feng-Qi Cui , Bin Luo , Meng Li , Tong Xu , Enhong Chen

A deep latent variable model is a powerful method for capturing complex distributions. These models assume that underlying structures, but unobserved, are present within the data. In this dissertation, we explore high-dimensional problems…

Machine Learning · Computer Science 2024-06-13 Khuong Vo

Deep learning shows promise for medical image analysis but lacks interpretability, hindering adoption in healthcare. Attribution techniques that explain model reasoning may increase trust in deep learning among clinical stakeholders. This…

Machine Learning · Computer Science 2023-08-08 Yusuf Brima , Marcellin Atemkeng

Probability density function estimation with weighted samples is the main foundation of all adaptive importance sampling algorithms. Classically, a target distribution is approximated either by a non-parametric model or within a parametric…

Machine Learning · Computer Science 2023-10-16 Julien Demange-Chryst , François Bachoc , Jérôme Morio , Timothé Krauth

Blood vessels (BVs) play a critical role in the Tumor Micro-Environment (TME), potentially influencing cancer progression and treatment response. However, manually quantifying BVs in Hematoxylin and Eosin (H&E) stained images is challenging…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Jiaqi Lv , Stefan S Antonowicz , Shan E Ahmed Raza

Vascular remodelling is inherent to the pathogenesis of many diseases including cancer, neurodegeneration, fibrosis, hypertension, and diabetes. In this paper, a new susceptibility-contrast based MRI approach is established to analyse…

Magnetic Resonance Fingerprinting (MRF) enables the simultaneous quantification of multiple properties of biological tissues. It relies on a pseudo-random acquisition and the matching of acquired signal evolutions to a precomputed…

Each training step for a variational autoencoder (VAE) requires us to sample from the approximate posterior, so we usually choose simple (e.g. factorised) approximate posteriors in which sampling is an efficient computation that fully…

Machine Learning · Statistics 2018-05-29 Laurence Aitchison , Vincent Adam , Srinivas C. Turaga

We present a novel technique for amortized posterior estimation using Normalizing Flows trained with likelihood-weighted importance sampling. This approach allows for the efficient inference of theoretical parameters in high-dimensional…

Machine Learning · Computer Science 2026-02-23 Rajneil Baruah

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

Machine Learning · Computer Science 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

Estimating the structure of Bayesian networks as directed acyclic graphs (DAGs) from observational data is a fundamental challenge, particularly in causal discovery. Bayesian approaches excel by quantifying uncertainty and addressing…

Machine Learning · Computer Science 2026-02-17 Edwin V. Bonilla , Pantelis Elinas , He Zhao , Maurizio Filippone , Vassili Kitsios , Terry O'Kane

We propose the first unsupervised and learning-based method to identify interpretable directions in h-space of pre-trained diffusion models. Our method is derived from an existing technique that operates on the GAN latent space.…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Zijian Zhang , Luping Liu , Zhijie Lin , Yichen Zhu , Zhou Zhao

Uncovering the underlying ordinary differential equations (ODEs) that govern dynamic systems is crucial for advancing our understanding of complex phenomena. Traditional symbolic regression methods often struggle to capture the temporal…

Machine Learning · Computer Science 2025-06-24 Yang Chang , Kuang-Da Wang , Ping-Chun Hsieh , Cheng-Kuan Lin , Wen-Chih Peng