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Deep learning models have demonstrated high-quality performance in areas such as image classification and speech processing. However, creating a deep learning model using electronic health record (EHR) data, requires addressing particular…

Machine Learning · Computer Science 2020-03-06 Amirsina Torfi , Edward A. Fox

The growing availability of clinical data has increased the use of machine learning, yet centralized data aggregation is often infeasible for sensitive health information. Federated Learning (FL) offers a distributed alternative, but its…

Machine Learning · Computer Science 2026-05-26 Anisa Halimi , Liubov Nedoshivina , Kieran Fraser , Stefano Braghin

Generative modeling has been used frequently in synthetic data generation. Fairness and privacy are two big concerns for synthetic data. Although Recent GAN [\cite{goodfellow2014generative}] based methods show good results in preserving…

Machine Learning · Computer Science 2023-07-04 Weijie Xu , Jinjin Zhao , Francis Iannacci , Bo Wang

Single nucleotide polymorphism (SNP) datasets are fundamental to genetic studies but pose significant privacy risks when shared. The correlation of SNPs with each other makes strong adversarial attacks such as masked-value reconstruction,…

Machine Learning · Computer Science 2025-10-08 Shadi Rahimian , Mario Fritz

The amount of data for processing and categorization grows at an ever increasing rate. At the same time the demand for collaboration and transparency in organizations, government and businesses, drives the release of data from internal…

Machine Learning · Computer Science 2020-08-26 Jan Neerbek

Motivation: Cutting the cost of DNA sequencing technology led to a quantum leap in the availability of genomic data. While sharing genomic data across researchers is an essential driver of advances in health and biomedical research, the…

Genomics · Quantitative Biology 2022-01-03 Nour Almadhoun Alserr , Ozgur Ulusoy , Erman Ayday , Onur Mutlu

Privacy-preserving synthetic data offers a promising solution to harness segregated data in high-stakes domains where information is compartmentalized for regulatory, privacy, or institutional reasons. This survey provides a comprehensive…

Cryptography and Security · Computer Science 2025-03-28 Viktor Schlegel , Anil A Bharath , Zilong Zhao , Kevin Yee

This paper studies federated learning for nonparametric regression in the context of distributed samples across different servers, each adhering to distinct differential privacy constraints. The setting we consider is heterogeneous,…

Statistics Theory · Mathematics 2024-06-12 T. Tony Cai , Abhinav Chakraborty , Lasse Vuursteen

We have developed a novel method to rapidly obtain homologous genomic data for phylogenetics directly from next-generation sequencing reads without the use of a reference genome. This software, called SISRS, avoids the time consuming steps…

Populations and Evolution · Quantitative Biology 2015-06-12 Rachel S. Schwartz , Kelly Harkins , Anne C. Stone , Reed A. Cartwright

The data revolution holds significant promise for the health sector. Vast amounts of data collected from individuals will be transformed into knowledge, AI models, predictive systems, and best practices. One area of health that stands to…

Cryptography and Security · Computer Science 2024-07-15 Zahra Rahmani , Nahal Shahini , Nadav Gat , Zebin Yun , Yuzhou Jiang , Ofir Farchy , Yaniv Harel , Vipin Chaudhary , Mahmood Sharif , Erman Ayday

Genomic data are becoming increasingly valuable as we develop methods to utilize the information at scale and gain a greater understanding of how genetic information relates to biological function. Advances in synthetic biology and the…

Differential privacy (DP) has been accepted as a rigorous criterion for measuring the privacy protection offered by random mechanisms used to obtain statistics or, as we will study here, synthetic datasets from confidential data. Methods to…

Methodology · Statistics 2024-05-09 Leila Nombo , Anne-Sophie Charest

This work studies formal utility and privacy guarantees for a simple multiplicative database transformation, where the data are compressed by a random linear or affine transformation, reducing the number of data records substantially, while…

Machine Learning · Statistics 2009-01-13 Shuheng Zhou , Katrina Ligett , Larry Wasserman

The rapid advance of DNA sequencing technologies has yielded databases of thousands of genomes. To search and index these databases effectively, it is important that we take advantage of the similarity between those genomes. Several authors…

Data Structures and Algorithms · Computer Science 2014-12-05 Travis Gagie , Simon J. Puglisi

Popular online enrichment analysis tools from the field of molecular systems biology provide users with the ability to submit their experimental results as gene sets for individual analysis. Such queries are kept private, and have never…

Molecular Networks · Quantitative Biology 2016-01-08 Avi Ma'ayan , Neil R. Clark

The need to analyze sensitive data, such as medical records or financial data, has created a critical research challenge in recent years. In this paper, we adopt the framework of differential privacy, and explore mechanisms for generating…

Cryptography and Security · Computer Science 2024-05-09 Nikolija Bojkovic , Po-Ling Loh

We revisit the problem of designing scalable protocols for private statistics and private federated learning when each device holds its private data. Locally differentially private algorithms require little trust but are (provably) limited…

This paper presents a novel approach to classical linear regression, enabling model computation from data streams or in a distributed setting while preserving data privacy in federated environments. We extend this framework to generalized…

Computation · Statistics 2026-05-29 Daniel Tinoco , Raquel Menezes , Carlos Baquero

Federated learning has emerged as an attractive approach to protect data privacy by eliminating the need for sharing clients' data while reducing communication costs compared with centralized machine learning algorithms. However, recent…

Typical personal medical data contains sensitive information about individuals. Storing or sharing the personal medical data is thus often risky. For example, a short DNA sequence can provide information that can not only identify an…

Cryptography and Security · Computer Science 2019-02-01 Ho Bae , Dahuin Jung , Sungroh Yoon