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Advances in medical imaging and deep learning have propelled progress in whole slide image (WSI) analysis, with multiple instance learning (MIL) showing promise for efficient and accurate diagnostics. However, conventional MIL models often…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Xianrui Li , Yufei Cui , Jun Li , Antoni B. Chan

In multiple instance multiple label learning, each sample, a bag, consists of multiple instances. To alleviate labeling complexity, each sample is associated with a set of bag-level labels leaving instances within the bag unlabeled. This…

Machine Learning · Computer Science 2021-07-28 Tam Nguyen , Raviv Raich

In the supervised learning setting termed Multiple-Instance Learning (MIL), the examples are bags of instances, and the bag label is a function of the labels of its instances. Typically, this function is the Boolean OR. The learner observes…

Machine Learning · Computer Science 2015-03-19 Sivan Sabato , Naftali Tishby

Training a Convolutional Neural Network (CNN) for semantic segmentation typically requires to collect a large amount of accurate pixel-level annotations, a hard and expensive task. In contrast, simple image tags are easier to gather. With…

Computer Vision and Pattern Recognition · Computer Science 2019-02-25 Carolina Redondo-Cabrera , Marcos Baptista-Ríos , Roberto J. López-Sastre

This paper introduces MAD-MIL, a Multi-head Attention-based Deep Multiple Instance Learning model, designed for weakly supervised Whole Slide Images (WSIs) classification in digital pathology. Inspired by the multi-head attention mechanism…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Hassan Keshvarikhojasteh , Josien Pluim , Mitko Veta

Supervised object detection and semantic segmentation require object or even pixel level annotations. When there exist image level labels only, it is challenging for weakly supervised algorithms to achieve accurate predictions. The accuracy…

Computer Vision and Pattern Recognition · Computer Science 2018-03-06 Weifeng Ge , Sibei Yang , Yizhou Yu

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Shaohua Li , Yong Liu , Xiuchao Sui , Cheng Chen , Gabriel Tjio , Daniel Shu Wei Ting , Rick Siow Mong Goh

Patient-level diagnosis of severity in ulcerative colitis (UC) is common in real clinical settings, where the most severe score in a patient is recorded. However, previous UC classification methods (i.e., image-level estimation) mainly…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Kaito Shiku , Kazuya Nishimura , Daiki Suehiro , Kiyohito Tanaka , Ryoma Bise

Malignant brain tumors have become an aggressive and dangerous disease that leads to death worldwide.Multi-modal MRI data is crucial for accurate brain tumor segmentation, but missing modalities common in clinical practice can severely…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Bingcang Huang , Kai Chen , Lin Gu , Zhe Wang , Sai Wu , Chang Yao

Early diagnosis of lung cancer is a key intervention for the treatment of lung cancer computer aided diagnosis (CAD) can play a crucial role. However, most published CAD methods treat lung cancer diagnosis as a lung nodule classification…

Image and Video Processing · Electrical Eng. & Systems 2022-10-12 Junhua Chen , Haiyan Zeng , Chong Zhang , Zhenwei Shi , Andre Dekker , Leonard Wee , Inigo Bermejo

This work addresses the task of completely weakly supervised class-incremental learning for semantic segmentation to learn segmentation for both base and additional novel classes using only image-level labels. While class-incremental…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 David Minkwan Kim , Soeun Lee , Byeongkeun Kang

Weakly supervised instance segmentation (WSIS) using only image-level labels is a challenging task due to the difficulty of aligning coarse annotations with the finer task. However, with the advancement of deep neural networks (DNNs), WSIS…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Zecheng Li , Zening Zeng , Yuqi Liang , Jin-Gang Yu

The deployment of machine learning solutions in real-world scenarios often involves addressing the challenge of out-of-distribution (OOD) detection. While significant efforts have been devoted to OOD detection in classical supervised…

Computer Vision and Pattern Recognition · Computer Science 2023-11-10 Loïc Le Bescond , Maria Vakalopoulou , Stergios Christodoulidis , Fabrice André , Hugues Talbot

Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a frozen patch encoder, a projection layer, and a slide-level aggregator. While encoders and…

Quantitative Methods · Quantitative Biology 2026-05-19 Yucheng Xing , Pei Liu , Jingying Ma , Ruping Hong , Jiangdong Qiu , Tianyu Liu , Kai He , Ling Huang , Mengling Feng

We study the problem of learning from aggregate observations where supervision signals are given to sets of instances instead of individual instances, while the goal is still to predict labels of unseen individuals. A well-known example is…

Machine Learning · Statistics 2021-01-08 Yivan Zhang , Nontawat Charoenphakdee , Zhenguo Wu , Masashi Sugiyama

Modern foundation models provide highly expressive visual representations, yet adapting them to high-resolution medical imaging remains challenging due to limited annotations and weak supervision. Mammography, in particular, is…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Nikola Jovišić , Milica Škipina , Nicola Dall'Asen , Dubravko Ćulibrk

Multiple instance learning (MIL) has been successfully applied for whole slide images (WSIs) analysis in computational pathology, enabling a wide range of prediction tasks from tumor subtyping to inferring genetic mutations and multi-omics…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Junyu Li , Ye Zhang , Wen Shu , Xiaobing Feng , Yingchun Wang , Pengju Yan , Xiaolin Li , Chulin Sha , Min He

State-of-the-art visual recognition and detection systems increasingly rely on large amounts of training data and complex classifiers. Therefore it becomes increasingly expensive both to manually annotate datasets and to keep running times…

Computer Vision and Pattern Recognition · Computer Science 2014-12-02 Stefan Mathe , Cristian Sminchisescu

In this paper, two methods for multiple instance target characterization, MI-SMF and MI-ACE, are presented. MI-SMF and MI-ACE estimate a discriminative target signature from imprecisely-labeled and mixed training data. In many applications,…

Computer Vision and Pattern Recognition · Computer Science 2017-09-14 Alina Zare , Changzhe Jiao , Taylor Glenn

Fetal abdominal malformations are serious congenital anomalies that require accurate diagnosis to guide pregnancy management and reduce mortality. Although AI has demonstrated significant potential in medical diagnosis, its application to…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Huanwen Liang , Jingxian Xu , Yuanji Zhang , Yuhao Huang , Yuhan Zhang , Xin Yang , Ran Li , Xuedong Deng , Yanjun Liu , Guowei Tao , Yun Wu , Sheng Zhao , Xinru Gao , Dong Ni
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