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Brain extraction (skull stripping) is a challenging problem in neuroimaging. It is due to the variability in conditions from data acquisition or abnormalities in images, making brain morphology and intensity characteristics changeable and…

Computer Vision and Pattern Recognition · Computer Science 2022-01-31 Duy H. M. Nguyen , Duy M. Nguyen , Mai T. N. Truong , Thu Nguyen , Khanh T. Tran , Nguyen A. Triet , Pham T. Bao , Binh T. Nguyen

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

The field of computer vision is undergoing a paradigm shift toward large-scale foundation model pre-training via self-supervised learning (SSL). Leveraging large volumes of unlabeled brain MRI data, such models can learn anatomical priors…

Image and Video Processing · Electrical Eng. & Systems 2026-01-15 Petros Koutsouvelis , Matej Gazda , Leroy Volmer , Sina Amirrajab , Kamil Barbierik , Branislav Setlak , Jakub Gazda , Peter Drotar

Skull-stripping is the removal of background and non-brain anatomical features from brain images. While many skull-stripping tools exist, few target pediatric populations. With the emergence of multi-institutional pediatric data acquisition…

Image and Video Processing · Electrical Eng. & Systems 2025-12-05 William Kelley , Nathan Ngo , Adrian V. Dalca , Bruce Fischl , Lilla Zöllei , Malte Hoffmann

Skull stripping for brain MR images is a basic segmentation task. Although many methods have been proposed, most of them focused mainly on the adult MR images. Skull stripping for infant MR images is more challenging due to the small size…

Computer Vision and Pattern Recognition · Computer Science 2019-10-11 Qian Zhang , Li Wang , Xiaopeng Zong , Weili Lin , Gang Li , Dinggang Shen

Automatic segmentation of the musculoskeletal system in pediatric magnetic resonance (MR) images is a challenging but crucial task for morphological evaluation in clinical practice. We propose a deep learning-based regularized segmentation…

Image and Video Processing · Electrical Eng. & Systems 2021-05-31 Arnaud Boutillon , Bhushan Borotikar , Christelle Pons , Valérie Burdin , Pierre-Henri Conze

Magnetic resonance imaging (MRI) is central to the diagnosis of multiple sclerosis, where the identification of biomarkers such as the central vein sign benefits from high-resolution images. However, most clinical brain MRI scans are…

Optimization and Control · Mathematics 2026-03-05 Matteo Cannas , Alice Mariottini , Luca Massacesi , Federica Porta , Simone Rebegoldi , Andrea Sebastiani

Skull stripping magnetic resonance images (MRI) of the human brain is an important process in many image processing techniques, such as automatic segmentation of brain structures. Numerous methods have been developed to perform this task,…

Image and Video Processing · Electrical Eng. & Systems 2026-04-16 Hjalti Thrastarson , Lotta M. Ellingsen

The main focus of this work is a novel framework for the joint reconstruction and segmentation of parallel MRI (PMRI) brain data. We introduce an image domain deep network for calibrationless recovery of undersampled PMRI data. The proposed…

Image and Video Processing · Electrical Eng. & Systems 2021-02-03 Aniket Pramanik , Mathews Jacob

Skullstripping is defined as the task of segmenting brain tissue from a full head magnetic resonance image~(MRI). It is a critical component in neuroimage processing pipelines. Downstream deformable registration and whole brain segmentation…

Computer Vision and Pattern Recognition · Computer Science 2019-04-30 Amod Jog , P. Ellen Grant , Joseph L. Jacobson , Andre van der Kouwe , Ernesta M. Meintjes , Bruce Fischl , Lilla Zöllei

The Plug-and-Play (PnP) framework was recently introduced for low-dose CT reconstruction to leverage the interpretability and the flexibility of model-based methods to incorporate various plugins, such as trained deep learning (DL) neural…

Image and Video Processing · Electrical Eng. & Systems 2022-02-16 Qifan Xu , Qihui Lyu , Dan Ruan , Ke Sheng

Reliable brain tumor segmentation in MRI is indispensable for treatment planning and outcome monitoring, yet models trained on curated benchmarks often fail under domain shifts arising from scanner and protocol variability as well as…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Yuanhan Wang , Yifei Chen , Shuo Jiang , Wenjing Yu , Mingxuan Liu , Beining Wu , Jinying Zong , Feiwei Qin , Changmiao Wang , Qiyuan Tian

Model generalization capacity at domain shift (e.g., various imaging protocols and scanners) is crucial for deep learning methods in real-world clinical deployment. This paper tackles the challenging problem of domain generalization, i.e.,…

Computer Vision and Pattern Recognition · Computer Science 2020-07-07 Quande Liu , Qi Dou , Pheng-Ann Heng

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and…

Machine Learning · Computer Science 2021-12-21 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

Skull stripping is a common preprocessing step that is often performed manually in Magnetic Resonance Imaging (MRI) pipelines, including functional MRI (fMRI). This manual process is time-consuming and operator dependent. Automating this…

Image and Video Processing · Electrical Eng. & Systems 2025-04-29 Sima Soltanpour , Rachel Utama , Arnold Chang , Md Taufiq Nasseef , Dan Madularu , Praveen Kulkarni , Craig Ferris , Chris Joslin

Whole brain extraction, also known as skull stripping, is a process in neuroimaging in which non-brain tissue such as skull, eyeballs, skin, etc. are removed from neuroimages. Skull striping is a preliminary step in presurgical planning,…

Image and Video Processing · Electrical Eng. & Systems 2020-06-05 Sara Ranjbar , Kyle W. Singleton , Lee Curtin , Cassandra R. Rickertsen , Lisa E. Paulson , Leland S. Hu , J. Ross Mitchell , Kristin R. Swanson

Skull-stripping separates the skull region of the head from the soft brain tissues. In many cases of brain image analysis, this is an essential preprocessing step in order to improve the final result. This is true for both registration and…

Computer Vision and Pattern Recognition · Computer Science 2012-04-03 Stefan Bauer , Lutz-P. Nolte , Mauricio Reyes

Aggregating multi-subject functional magnetic resonance imaging (fMRI) data is indispensable for generating valid and general inferences from patterns distributed across human brains. The disparities in anatomical structures and functional…

Machine Learning · Computer Science 2019-11-20 Weida Li , Mingxia Liu , Fang Chen , Daoqiang Zhang

Fast data acquisition in Magnetic Resonance Imaging (MRI) is vastly in demand and scan time directly depends on the number of acquired k-space samples. Conventional MRI reconstruction methods for fast MRI acquisition mostly relied on…

Image and Video Processing · Electrical Eng. & Systems 2019-09-10 Ali Pour Yazdanpanah , Onur Afacan , Simon K. Warfield

Since the various MR contrasts of a given anatomy contain redundant information, one contrast can be used to guide the reconstruction of another undersampled contrast acquired subsequently in the same session. To solve this reconstruction…

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