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We use a coarse-grained molecular model to study the self-assembly process of complexes of cationic and neutral lipids with DNA molecules ("lipoplexes") - a promising nonviral carrier of DNA for gene therapy. We identify the resulting…

Soft Condensed Matter · Physics 2011-05-31 Oded Farago , Niels Grønbech-Jensen

The growth dynamics of rigid biopolymers, consisting of $N$ parallel protofilaments, is investigated theoretically using simple approximate models. In our approach, the structure of a polymer's growing end and lateral interactions between…

Statistical Mechanics · Physics 2009-11-10 Evgeny B. Stukalin , Anatoly B. Kolomeisky

We show that hydrodynamic turbulent cloud simulations naturally produce large filaments made up of a network of smaller and coherent sub-filaments. Such simulations resemble observations of filaments and fibres in nearby molecular clouds.…

Astrophysics of Galaxies · Physics 2015-12-09 Rowan J. Smith , Simon C. O. Glover , Ralf S. Klessen , Gary A. Fuller

The mechanical properties of molecules are today captured by single molecule manipulation experiments, so that polymer features are tested at a nanometric scale. Yet devising mathematical models to get further insight beyond the commonly…

From understanding the sand on the beach to the foam on your beer, soft sphere simulations have been crucial to the study of the amorphous world around us. However, many of the materials we interact with on a daily basis aren't comprised of…

Soft Condensed Matter · Physics 2024-03-18 R. C. Dennis

Loop formation in long molecules occurs many places in nature, from solutions of carbon nanotubes to polymers inside a cell. In this article, we review theoretical studies of the static and dynamic properties of polymer loops. For example,…

Biological Physics · Physics 2007-05-23 Suckjoon Jun , John Bechhoefer

Capillary thinning of polymeric fluids is central to biological and industrial processes, yet the mechanisms governing thinning dynamics remain unresolved, especially for semi-flexible polymers. Using ideal solutions of semi-flexible DNA,…

Soft Condensed Matter · Physics 2025-03-19 Vincenzo Calabrese , Silvia Nardone , Amy Q. Shen , Simon J. Haward

Biofilament-motor protein complexes are ubiquitous in biology and drive the transport of cargo vital for many fundamental cellular processes. As they move, motor proteins exert compressive forces on the filaments to which they are attached,…

Biological Physics · Physics 2024-06-12 Bethany Clarke , Yongyun Hwang , Eric Keaveny

Large scale molecular dynamics simulations are used to study the dispersion of nanoparticles (NPs) in a polymer film during solvent evaporation. As the solvent evaporates, a dense polymer-rich skin layer forms at the liquid/vapor interface,…

Soft Condensed Matter · Physics 2016-05-23 Shengfeng Cheng , Gary S. Grest

Formation of bacterial colonies as biofilm on the surface/interface of various objects has the potential to impact not only human health and disease but also energy and environmental considerations. Biofilms can be regarded as soft…

Fluid Dynamics · Physics 2015-09-15 Pallab Barai , Aloke Kumar , Partha P. Mukherjee

Filaments are crucial intermediaries in the star formation process. Recent observations of filaments show that - \textbf{(i)} a number of them are non-singular entities, and rather a bundle of velocity coherent fibres, and \textbf{(ii)}…

Astrophysics of Galaxies · Physics 2021-01-13 S. Anathpindika , J. Di Francesco

A filament of liquid is usually unstable and breaks up into small droplets, while a filament of polymer solution is known to be quite stable against such instability, and they form a stable configuration of filament connecting two spherical…

Soft Condensed Matter · Physics 2020-08-20 Jiajia Zhou , Masao Doi

Genetic information is stored in a linear sequence of base-pairs; however, thermal fluctuations and complex DNA conformations such as folds and loops make it challenging to order genomic material for in vitro analysis. In this work, we…

We present an analytically solvable model for self-assembly of a molecular complex on a filament. The process is driven by a seed molecule that undergoes facilitated diffusion, which is a search strategy that combines diffusion in…

Statistical Mechanics · Physics 2015-11-04 Ziya Kalay

Soft slender structures are ubiquitous in natural and artificial systems and can be observed at scales that range from the nanometric to the kilometric, from polymers to space tethers. We present a practical numerical approach to simulate…

Fluid Dynamics · Physics 2017-08-18 Mattia Gazzola , Levi H. Dudte , Andrew G. McCormick , L. Mahadevan

The presence of a very small amount of high molecular weight polymer significantly delays the pinch-off singularity of a drop of water falling from a faucet, and leads to the formation of a long-lived cylindrical filament. In this paper we…

Soft Condensed Matter · Physics 2009-11-10 C. Wagner , Y. Amarouchene , D. Bonn , J. Eggers

We present a novel buckling instability relevant to membrane budding in eukaryotic cells. In this mechanism, curved filaments bind to a lipid bilayer without changing its intrinsic curvature. As more and more filaments adsorb, newly added…

Biological Physics · Physics 2009-07-16 Martin Lenz , Daniel J. G. Crow , Jean-François Joanny

Microscopic organisms, such as bacteria, have the ability of colonizing surfaces and developing biofilms that can determine diseases and infections. Most bacteria secrete a significant amount of extracellular polymer substances that are…

Biological Physics · Physics 2021-05-19 Francisco Javier Lobo-Cabrera , Alessandro Patti , Fernando Govantes , Alejandro Cuetos

We introduce a particle-based model of self-replicating cells on a deformable substrate composed of the dermis and the basement membrane and investigate the relationship between dermal deformations and stem cell pattering on it. We show…

Tissues and Organs · Quantitative Biology 2018-08-22 Yasuaki Kobayashi , Yusuke Yasugahira , Hiroyuki Kitahata , Mika Watanabe , Ken Natsuga , Masaharu Nagayama

A theory is presented for the binding of small molecules such as surfactants to semiflexible polymers. The persistence length is assumed to be large compared to the monomer size but much smaller than the total chain length. Such polymers…

Soft Condensed Matter · Physics 2009-09-25 Haim Diamant , David Andelman