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Data-driven predictive methods which can efficiently and accurately transform protein sequences into biologically active structures are highly valuable for scientific research and medical development. Determining accurate folding landscape…

Contact-assisted protein folding has made very good progress, but two challenges remain. One is accurate contact prediction for proteins lack of many sequence homologs and the other is that time-consuming folding simulation is often needed…

Biomolecules · Quantitative Biology 2022-10-12 Jinbo Xu

High-fidelity physics simulations are powerful tools in the design and optimization of charged particle accelerators. However, the computational burden of these simulations often limits their use in practice for design optimization and…

Accelerator Physics · Physics 2020-04-15 Auralee Edelen , Nicole Neveu , Yannick Huber , Mattias Frey , Christopher Mayes , Andreas Adelmann

Existing approaches to train neural networks that use large images require to either crop or down-sample data during pre-processing, use small batch sizes, or split the model across devices mainly due to the prohibitively limited memory…

Image and Video Processing · Electrical Eng. & Systems 2020-03-12 Kushal Datta , Imtiaz Hossain , Sun Choi , Vikram Saletore , Kyle Ambert , William J. Godinez , Xian Zhang

The training process of Deep Neural Network (DNN) is compute-intensive, often taking days to weeks to train a DNN model. Therefore, parallel execution of DNN training on GPUs is a widely adopted approach to speed up the process nowadays.…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-10-29 Chi-Chung Chen , Chia-Lin Yang , Hsiang-Yun Cheng

This article presents design techniques proposed for efficient hardware implementation of feedforward artificial neural networks (ANNs) under parallel and time-multiplexed architectures. To reduce their design complexity, after the weights…

Hardware Architecture · Computer Science 2021-08-05 Mohammadreza Esmali Nojehdeh , Sajjad Parvin , Mustafa Altun

Recent advancements in machine learning (ML) are transforming the field of structural biology. For example, AlphaFold, a groundbreaking neural network for protein structure prediction, has been widely adopted by researchers. The…

Training large-scale deep learning models has become a key challenge for the scientific community and industry. While the massive use of GPUs can significantly speed up training times, this approach has a negative impact on efficiency. In…

Machine Learning · Computer Science 2025-09-04 David Cortes , Carlos Juiz , Belen Bermejo

Large language models~(LLMs) are known for their high demand on computing resources and memory due to their substantial model size, which leads to inefficient inference on moderate GPU systems. Techniques like quantization or pruning can…

Computational Engineering, Finance, and Science · Computer Science 2024-11-26 Wenxiang Lin , Xinglin Pan , Shaohuai Shi , Xuan Wang , Xiaowen Chu

Accelerated edge devices, like Nvidia's Jetson with 1000+ CUDA cores, are increasingly used for DNN training and federated learning, rather than just for inferencing workloads. A unique feature of these compact devices is their fine-grained…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-07-22 Prashanthi S. K. , Saisamarth Taluri , Beautlin S , Lakshya Karwa , Yogesh Simmhan

Domain-specialized FPGAs have delivered unprecedented performance for low-latency inference across scientific and industrial workloads, yet nearly all existing accelerators assume static models trained offline, relegating learning and…

Hardware Architecture · Computer Science 2026-02-03 Duc Hoang

The increasing complexity of modern deep neural network models and the expanding sizes of datasets necessitate the development of optimized and scalable training methods. In this white paper, we addressed the challenge of efficiently…

Machine Learning · Computer Science 2024-04-29 Raphael Ruschel , A. S. M. Iftekhar , B. S. Manjunath , Suya You

There has been considerable research into improving Fast Fourier Transform (FFT) performance through parallelization and optimization for specialized hardware. However, even with those advancements, processing of very large files, over 1TB…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-07-28 Rostislav Tsiomenko , Bradley S. Rees

The Fast Fourier Transform (FFT), as a core computation in a wide range of scientific applications, is increasingly threatened by reliability issues. In this paper, we introduce TurboFFT, a high-performance FFT implementation equipped with…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-05-07 Shixun Wu , Yujia Zhai , Jinyang Liu , Jiajun Huang , Zizhe Jian , Huangliang Dai , Sheng Di , Zizhong Chen , Franck Cappello

This paper presents ProFL, a new framework that effectively addresses the memory constraints in FL. Rather than updating the full model during local training, ProFL partitions the model into blocks based on its original architecture and…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-22 Yebo Wu , Li Li , Chengzhong Xu

Training deep neural networks (DNNs) requires significantly more computation and memory than inference, making runtime adaptation of DNNs challenging on resource-limited IoT platforms. We propose InstantFT, an FPGA-based method for…

Machine Learning · Computer Science 2025-06-10 Keisuke Sugiura , Hiroki Matsutani

Currently, training large-scale deep learning models is typically achieved through parallel training across multiple GPUs. However, due to the inherent communication overhead and synchronization delays in traditional model parallelism…

Computer Vision and Pattern Recognition · Computer Science 2024-11-21 Xiuyuan Guo , Chengqi Xu , Guinan Guo , Feiyu Zhu , Changpeng Cai , Peizhe Wang , Xiaoming Wei , Junhao Su , Jialin Gao

After the tremendous development of neural networks trained by backpropagation, it is a good time to develop other algorithms for training neural networks to gain more insights into networks. In this paper, we propose a new algorithm for…

Machine Learning · Computer Science 2020-07-01 Benyamin Ghojogh , Fakhri Karray , Mark Crowley

Motivation Protein fold recognition is an important problem in structural bioinformatics. Almost all traditional fold recognition methods use sequence (homology) comparison to indirectly predict the fold of a tar get protein based on the…

Machine Learning · Computer Science 2017-06-06 Jie Hou , Badri Adhikari , Jianlin Cheng

Deploying pretrained visual models in real-world environments often suffers from significant performance degradation due to the diversity of testing scenarios. Continuous adaptation of learning models on edge devices via unlabeled data…

Neural and Evolutionary Computing · Computer Science 2026-05-08 Jianming Lv , Chengjun Wang , Depin Liang , Qianli Ma , Wei Chen , Xueqi Cheng
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