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Deep learning for histopathology has been successfully used for disease classification, image segmentation and more. However, combining image and text modalities using current state-of-the-art methods has been a challenge due to the high…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Saurav Sengupta , Donald E. Brown

The popular use of histopathology images, such as hematoxylin and eosin (H&E), has proven to be useful in detecting tumors. However, moving such cancer cases forward for treatment requires accurate on the amount of the human epidermal…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Olaide N. Oyelade , Oliver Hoxey , Yulia Humrye

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The difference in procedures to acquire WSIs at various trial sites gives rise to variability in the histopathology images, thus making consistent…

Image and Video Processing · Electrical Eng. & Systems 2022-04-07 Milad Sikaroudi , Shahryar Rahnamayan , H. R. Tizhoosh

Determining lymphoma subtypes is a crucial step for better patient treatment targeting to potentially increase their survival chances. In this context, the existing gold standard diagnosis method, which relies on gene expression technology,…

Image and Video Processing · Electrical Eng. & Systems 2024-07-24 Bilel Guetarni , Feryal Windal , Halim Benhabiles , Marianne Petit , Romain Dubois , Emmanuelle Leteurtre , Dominique Collard

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

We propose WS-DINO as a novel framework to use weak label information in learning phenotypic representations from high-content fluorescent images of cells. Our model is based on a knowledge distillation approach with a vision transformer…

Computer Vision and Pattern Recognition · Computer Science 2022-11-18 Jan Oscar Cross-Zamirski , Guy Williams , Elizabeth Mouchet , Carola-Bibiane Schönlieb , Riku Turkki , Yinhai Wang

Deep learning has transformed computer vision but relies heavily on large labeled datasets and computational resources. Transfer learning, particularly fine-tuning pretrained models, offers a practical alternative; however, models…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Iván Matas , Carmen Serrano , Miguel Nogales , David Moreno , Lara Ferrándiz , Teresa Ojeda , Begoña Acha

Pathology foundation models learn morphological representations through self-supervised pretraining on large-scale whole-slide images, yet they do not explicitly capture the underlying molecular state of the tissue. Spatial transcriptomics…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Minsoo Lee , Jonghyun Kim , Juseung Yun , Sunwoo Yu , Jongseong Jang

Using features extracted from networks pretrained on ImageNet is a common practice in applications of deep learning for digital pathology. However it presents the downside of missing domain specific image information. In digital pathology,…

Computer Vision and Pattern Recognition · Computer Science 2020-01-14 Jacob Gildenblat , Eldad Klaiman

Colonoscopy plays a crucial role in the diagnosis and prognosis of various gastrointestinal diseases. Due to the challenges of collecting large-scale high-quality ground truth annotations for colonoscopy images, and more generally medical…

Image and Video Processing · Electrical Eng. & Systems 2023-12-21 Heming Yao , Jérôme Lüscher , Benjamin Gutierrez Becker , Josep Arús-Pous , Tommaso Biancalani , Amelie Bigorgne , David Richmond

One of the main obstacles of adopting digital pathology is the challenge of efficient processing of hyperdimensional digitized biopsy samples, called whole slide images (WSIs). Exploiting deep learning and introducing compact WSI…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Azam Asilian Bidgoli , Shahryar Rahnamayan , Taher Dehkharghanian , Abtin Riasatian , H. R. Tizhoosh

Survival prediction based on whole slide images (WSIs) is a challenging task for patient-level multiple instance learning (MIL). Due to the vast amount of data for a patient (one or multiple gigapixels WSIs) and the irregularly shaped…

Computer Vision and Pattern Recognition · Computer Science 2023-07-03 Zhuchen Shao , Yang Chen , Hao Bian , Jian Zhang , Guojun Liu , Yongbing Zhang

We provide in this paper a comprehensive comparison of various transfer learning strategies and deep learning architectures for computer-aided classification of adult-type diffuse gliomas. We evaluate the generalizability of out-of-domain…

Whole slide imaging (WSI) has transformed digital pathology by enabling computational analysis of gigapixel histopathology images. Recent foundation model advances have accelerated progress in computational pathology, facilitating joint…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Peihang Wu , Zehong Chen , Lijian Xu

Whole slide image (WSI) classification is a crucial problem for cancer diagnostics in clinics and hospitals. A WSI, acquired at gigapixel size, is commonly tiled into patches and processed by multiple-instance learning (MIL) models.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Doanh C. Bui , Jin Tae Kwak

Vision Transformers (ViTs) have ushered in a new era in computer vision, showcasing unparalleled performance in many challenging tasks. However, their practical deployment in computational pathology has largely been constrained by the sheer…

Computer Vision and Pattern Recognition · Computer Science 2023-12-21 Clément Grisi , Geert Litjens , Jeroen van der Laak

Histopathological images contain rich phenotypic information that can be used to monitor underlying mechanisms contributing to diseases progression and patient survival outcomes. Recently, deep learning has become the mainstream…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Chetan L. Srinidhi , Ozan Ciga , Anne L. Martel

Self-supervised learning has emerged as a powerful paradigm for training deep neural networks, particularly in medical imaging where labeled data is scarce. While current approaches typically rely on synthetic augmentations of single…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Andre Dourson , Kylie Taylor , Xiaoli Qiao , Michael Fitzke

Transfer learning has become a standard practice to mitigate the lack of labeled data in medical classification tasks. Whereas finetuning a downstream task using supervised ImageNet pretrained features is straightforward and extensively…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Tuan Truong , Sadegh Mohammadi , Matthias Lenga

Learning meaningful and interpretable representations from high-dimensional volumetric magnetic resonance (MR) images is essential for advancing personalized medicine. While Vision Transformers (ViTs) have shown promise in handling image…

Computer Vision and Pattern Recognition · Computer Science 2024-09-13 Qingqiao Hu , Daoan Zhang , Jiebo Luo , Zhenyu Gong , Benedikt Wiestler , Jianguo Zhang , Hongwei Bran Li