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Histopathological imaging is vital for cancer research and clinical practice, with multiplexed Immunofluorescence (MxIF) and Hematoxylin and Eosin (H&E) providing complementary insights. However, aligning different stains at the cell level…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Jun Jiang , Raymond Moore , Brenna Novotny , Leo Liu , Zachary Fogarty , Ray Guo , Markovic Svetomir , Chen Wang

Lesion detection in digital breast tomosynthesis (DBT) is an important and a challenging problem characterized by a low prevalence of images containing tumors. Due to the label scarcity problem, large deep learning models and…

Computer Vision and Pattern Recognition · Computer Science 2022-10-12 Yifan Zhang , Haoyu Dong , Nicholas Konz , Hanxue Gu , Maciej A. Mazurowski

Breast cancer is a leading cause of cancer-related mortality worldwide, and timely accurate diagnosis is critical to improving survival outcomes. While convolutional neural networks (CNNs) have demonstrated strong performance on…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Aditya Shribhagwan Khandelwal , Mohammad Samar Ansari , Asra Aslam

In this paper, an innovative microwave imaging (MI) approach for breast tumor diagnosis is proposed that employs a differential formulation of the inverse scattering problem (ISP) at hand to exploit arbitrary-fidelity priors on the…

Signal Processing · Electrical Eng. & Systems 2024-01-08 Francesco Zardi , Luca Tosi , Marco Salucci , Andrea Massa

Performance of deep learning algorithms decreases drastically if the data distributions of the training and testing sets are different. Due to variations in staining protocols, reagent brands, and habits of technicians, color variation in…

Computer Vision and Pattern Recognition · Computer Science 2020-12-01 Abhijeet Patil , Mohd. Talha , Aniket Bhatia , Nikhil Cherian Kurian , Sammed Mangale , Sunil Patel , Amit Sethi

Noise is one of the major problems that hinder an effective texture analysis of disease in medical images, which may cause variability in the reported diagnosis. In this paper seven texture measurement methods (two wavelet, two model and…

Computer Vision and Pattern Recognition · Computer Science 2015-12-29 Omar Sultan Al-Kadi

Double staining in histopathology, particularly for metaplastic breast cancer, typically employs H&E and P63 dyes. However, P63's tissue damage and high cost necessitate alternative methods. This study introduces xAI-CycleGAN, an advanced…

Image and Video Processing · Electrical Eng. & Systems 2023-12-07 Tibor Sloboda , Lukáš Hudec , Wanda Benešová

Breast cancer is one of the main causes of death worldwide. Histopathological cellularity assessment of residual tumors in post-surgical tissues is used to analyze a tumor's response to a therapy. Correct cellularity assessment increases…

Image and Video Processing · Electrical Eng. & Systems 2019-09-04 Alexander Rakhlin , Aleksei Tiulpin , Alexey A. Shvets , Alexandr A. Kalinin , Vladimir I. Iglovikov , Sergey Nikolenko

kin cancer is considered one of the most common type of cancer in several countries. Due to the difficulty and subjectivity in the clinical diagnosis of skin lesions, Computer-Aided Diagnosis systems are being developed for assist experts…

Computer Vision and Pattern Recognition · Computer Science 2022-01-27 José G. M. Esgario , Renato A. Krohling

One issue with computer based histopathology image analysis is that the size of the raw image is usually very large. Taking the raw image as input to the deep learning model would be computationally expensive while resizing the raw image to…

Computer Vision and Pattern Recognition · Computer Science 2019-03-01 Bolei Xu , Jingxin Liu , Xianxu Hou , Bozhi Liu , Jon Garibaldi , Ian O. Ellis , Andy Green , Linlin Shen , Guoping Qiu

Hematoxylin and Eosin (H&E) has been the gold standard in tissue analysis for decades, however, tissue specimens stained in different laboratories vary, often significantly, in appearance. This variation poses a challenge for both…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Umair Khan , Jouni Härkönen , Marjukka Friman , Leena Latonen , Teijo Kuopio , Pekka Ruusuvuori

Background and Purpose: Colorectal cancer is a common fatal malignancy, the fourth most common cancer in men, and the third most common cancer in women worldwide. Timely detection of cancer in its early stages is essential for treating the…

Mammography screening for early detection of breast lesions currently suffers from high amounts of false positive findings, which result in unnecessary invasive biopsies. Diffusion-weighted MR images (DWI) can help to reduce many of these…

We explored the fractal and multifractal characteristics of breast mammogram micrographs to identify quantitative biomarkers associated with breast cancer progression. In addition to conventional fractal and multifractal analyses, we…

Medical Physics · Physics 2025-05-28 Santanu Maity , Mousa Alrubayan , Prabhakar Pradhan

Several studies indicate that deep learning models can learn to detect breast cancer from mammograms (X-ray images of the breasts). However, challenges with overfitting and poor generalisability prevent their routine use in the clinic.…

Image and Video Processing · Electrical Eng. & Systems 2025-02-05 Emir Ahmed , Spencer A. Thomas , Ciaran Bench

Breast cancer is a relatively common cancer among gynecological cancers. Its diagnosis often relies on the pathology of cells in the lesion. The pathological diagnosis of breast cancer not only requires professionals and time, but also…

Image and Video Processing · Electrical Eng. & Systems 2024-04-15 MingXuan Xiao , Yufeng Li , Xu Yan , Min Gao , Weimin Wang

With the growth of digital networks such as the Internet, digital media have been explosively developed in e-commerce and online services. This causes problems such as illegal copy and fake ownership. Watermarking is proposed as one of the…

Multimedia · Computer Science 2016-04-02 Malihe Mardanpour , Mohammad Ali Zare Chahooki

The wavelet spectra is a common starting point for estimating the Hurst exponent of a self-similar signal using wavelet-based techniques. The decay of the $\log_2$ average energy of the detail wavelet coefficients as a function of the level…

Methodology · Statistics 2025-12-02 Raymond J. Hinton, , Pepa Ramírez Cobo , Brani Vidakovic

In this study, we develop a new CAD system for accurate thyroid cancer classification with emphasis on feature extraction. Prior studies have shown that thyroid texture is important for segregating the thyroid ultrasound images into…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Saurabh Saini , Kapil Ahuja , Marc C. Steinbach , Thomas Wick

The current standard for detecting human epidermal growth factor receptor 2 (HER2) status in breast cancer patients relies on HER2 amplification, identified through fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC).…

Image and Video Processing · Electrical Eng. & Systems 2024-09-27 Ardhendu Sekhar , Vrinda Goel , Garima Jain , Abhijeet Patil , Ravi Kant Gupta , Tripti Bameta , Swapnil Rane , Amit Sethi