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Gene expression analysis aims at identifying the genes able to accurately predict biological parameters like, for example, disease subtyping or progression. While accurate prediction can be achieved by means of many different techniques,…

Methodology · Statistics 2008-09-11 Christine De Mol , Sofia Mosci , Magali Traskine , Alessandro Verri

Society has come to rely on algorithms like classifiers for important decision making, giving rise to the need for ethical guarantees such as fairness. Fairness is typically defined by asking that some statistic of a classifier be…

Neural and Evolutionary Computing · Computer Science 2020-04-29 William La Cava , Jason H. Moore

Program synthesis--the automated generation of executable code from high-level specifications--has been a central goal of computer science for over fifty years. This thesis provides a comparative literature review of the main paradigms that…

Programming Languages · Computer Science 2025-08-04 Zurabi Kobaladze , Anna Arnania , Tamar Sanikidze

The problem of automatic software generation is known as Machine Programming. In this work, we propose a framework based on genetic algorithms to solve this problem. Although genetic algorithms have been used successfully for many problems,…

Neural and Evolutionary Computing · Computer Science 2023-04-04 Shantanu Mandal , Todd A. Anderson , Javier S. Turek , Justin Gottschlich , Shengtian Zhou , Abdullah Muzahid

Gene expression programming is an evolutionary optimization algorithm with the potential to generate interpretable and easily implementable equations for regression problems. Despite knowledge gained from previous optimizations being…

Neural and Evolutionary Computing · Computer Science 2025-02-05 Maximilian Reissmann , Yuan Fang , Andrew S. H. Ooi , Richard D. Sandberg

We consider the problem of automatically constructing computer programs from input-output examples. We investigate how to augment probabilistic and neural program synthesis methods with new search algorithms, proposing a framework called…

Machine Learning · Computer Science 2021-12-07 Nathanaël Fijalkow , Guillaume Lagarde , Théo Matricon , Kevin Ellis , Pierre Ohlmann , Akarsh Potta

The choice of crossover and mutation strategies plays a crucial role in the searchability, convergence efficiency and precision of genetic algorithms. In this paper, a novel improved genetic algorithm is proposed by improving the crossover…

Neural and Evolutionary Computing · Computer Science 2022-10-12 Dingming Yang , Zeyu Yu , Hongqiang Yuan , Yanrong Cui

Software is omnipresent within all factors of society. It is thus important to ensure that software are well tested to mitigate bad user experiences as well as the potential for severe financial and human losses. Software testing is however…

Software Engineering · Computer Science 2025-04-30 Jason Wang , Basem Suleiman , Muhammad Johan Alibasa

We address the problem of synthetic gene design using Bayesian optimization. The main issue when designing a gene is that the design space is defined in terms of long strings of characters of different lengths, which renders the…

Machine Learning · Statistics 2015-05-08 Javier González , Joseph Longworth , David C. James , Neil D. Lawrence

Generative AI systems have revolutionized human interaction by enabling natural language-based coding and problem solving. However, the inherent ambiguity of natural language often leads to imprecise instructions, forcing users to…

Artificial Intelligence · Computer Science 2025-07-02 Fabrizio Marozzo

Program Synthesis is the task of generating a program from a provided specification. Traditionally, this has been treated as a search problem by the programming languages (PL) community and more recently as a supervised learning problem by…

Artificial Intelligence · Computer Science 2018-06-11 Riley Simmons-Edler , Anders Miltner , Sebastian Seung

Many program synthesis tasks prove too challenging for even state-of-the-art language models to solve in single attempts. Search-based evolutionary methods offer a promising alternative by exploring solution spaces iteratively, but their…

Machine Learning · Computer Science 2026-03-17 Julien Pourcel , Cédric Colas , Pierre-Yves Oudeyer

Computational models of human language often involve combinatorial problems. For instance, a probabilistic parser may marginalize over exponentially many trees to make predictions. Algorithms for such problems often employ dynamic…

Computation and Language · Computer Science 2021-09-16 Tim Vieira , Ryan Cotterell , Jason Eisner

Combinatorial evolution - the creation of new things through the combination of existing things - can be a powerful way to evolve rather than design technical objects such as electronic circuits. Intriguingly, this seems to be an ongoing…

Software Engineering · Computer Science 2021-11-23 Sebastian Fix , Thomas Probst , Oliver Ruggli , Thomas Hanne , Patrik Christen

A key challenge in program synthesis is the astronomical size of the search space the synthesizer has to explore. In response to this challenge, recent work proposed to guide synthesis using learned probabilistic models. Obtaining such a…

Programming Languages · Computer Science 2020-10-20 Shraddha Barke , Hila Peleg , Nadia Polikarpova

Several recent advances in AI systems solve problems by providing a "scaffolding" program that structures multiple calls to language models (LMs) to generate better outputs. A scaffolding program is written in a programming language such as…

Computation and Language · Computer Science 2024-08-19 Eric Zelikman , Eliana Lorch , Lester Mackey , Adam Tauman Kalai

While Genetic Improvement (GI) is a useful paradigm to improve functional and nonfunctional aspects of software, existing techniques tended to use the same set of mutation operators for differing objectives, due to the difficulty of writing…

Software Engineering · Computer Science 2023-04-20 Sungmin Kang , Shin Yoo

Iterative compilation is a widely adopted technique to optimize programs for different constraints such as performance, code size and power consumption in rapidly evolving hardware and software environments. However, in case of statically…

Programming Languages · Computer Science 2014-07-16 Lianjie Luo , Yang Chen , Chengyong Wu , Shun Long , Grigori Fursin

Automated Synthesis Planning has recently re-emerged as a research area at the intersection of chemistry and machine learning. Despite the appearance of steady progress, we argue that imperfect benchmarks and inconsistent comparisons mask…

Machine Learning · Computer Science 2024-09-09 Krzysztof Maziarz , Austin Tripp , Guoqing Liu , Megan Stanley , Shufang Xie , Piotr Gaiński , Philipp Seidl , Marwin Segler

Large language models (LLMs) have shown impressive promise in code generation, yet their progress remains limited by the shortage of large-scale datasets that are both diverse and well-aligned with human reasoning. Most existing resources…

Machine Learning · Computer Science 2025-10-28 Amal Abed , Ivan Lukic , Jörg K. H. Franke , Frank Hutter
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