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This paper considers a novel application of deep AUC maximization (DAM) for multi-instance learning (MIL), in which a single class label is assigned to a bag of instances (e.g., multiple 2D slices of a CT scan for a patient). We address a…

Machine Learning · Computer Science 2023-06-07 Dixian Zhu , Bokun Wang , Zhi Chen , Yaxing Wang , Milan Sonka , Xiaodong Wu , Tianbao Yang

Multi-label classification has received considerable interest in recent years. Multi-label classifiers have to address many problems including: handling large-scale datasets with many instances and a large set of labels, compensating…

Machine Learning · Computer Science 2016-06-21 Amirhossein Akbarnejad , Mahdieh Soleymani Baghshah

Multi-instance multi-label (MIML) learning is widely applicated in numerous domains, such as the image classification where one image contains multiple instances correlated with multiple logic labels simultaneously. The related labels in…

Computer Vision and Pattern Recognition · Computer Science 2023-04-24 Houcheng Su , Jintao Huang , Daixian Liu , Rui Yan , Jiao Li , Chi-man Vong

In this work, we introduce a new information-theoretic perspective on Multiple Instance Learning (MIL) for parameter estimation with i.i.d. data, and show that MIL can outperform single-instance learners in low-signal regimes. Prior work…

Machine Learning · Computer Science 2025-12-03 Atakan Azakli , Bernd Stelzer

We propose a new problem formulation which is similar to, but more informative than, the binary multiple-instance learning problem. In this setting, we are given groups of instances (described by feature vectors) along with estimates of the…

Machine Learning · Computer Science 2012-07-09 Hendrik Kuck , Nando de Freitas

A new random forest based model for solving the Multiple Instance Learning (MIL) problem under small tabular data, called Soft Tree Ensemble MIL (STE-MIL), is proposed. A new type of soft decision trees is considered, which is similar to…

Machine Learning · Computer Science 2023-02-14 Andrei V. Konstantinov , Lev V. Utkin

With the emergence of diverse data collection techniques, objects in real applications can be represented as multi-modal features. What's more, objects may have multiple semantic meanings. Multi-modal and Multi-label (MMML) problem becomes…

Machine Learning · Computer Science 2019-07-30 Yi Zhang , Cheng Zeng , Hao Cheng , Chongjun Wang , Lei Zhang

Weakly Supervised Video Anomaly Detection (WSVAD) is challenging because the binary anomaly label is only given on the video level, but the output requires snippet-level predictions. So, Multiple Instance Learning (MIL) is prevailing in…

Computer Vision and Pattern Recognition · Computer Science 2023-03-23 Hui Lv , Zhongqi Yue , Qianru Sun , Bin Luo , Zhen Cui , Hanwang Zhang

Consider learning an imitation policy on the basis of demonstrated behavior from multiple environments, with an eye towards deployment in an unseen environment. Since the observable features from each setting may be different, directly…

Machine Learning · Statistics 2023-11-06 Ioana Bica , Daniel Jarrett , Mihaela van der Schaar

Instance-level image classification tasks have traditionally relied on single-instance labels to train models, e.g., few-shot learning and transfer learning. However, set-level coarse-grained labels that capture relationships among…

Machine Learning · Computer Science 2023-11-21 Renyu Zhang , Aly A. Khan , Yuxin Chen , Robert L. Grossman

Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Machine learning models have become integral to many fields, but their reliability, defined as producing dependable, trustworthy, and domain-consistent predictions, remains a critical concern. Multiple Instance Learning (MIL) models…

Computer Vision and Pattern Recognition · Computer Science 2025-12-10 Hassan Keshvarikhojasteh , Marc Aubreville , Christof A. Bertram , Josien P. W. Pluim , Mitko Veta

Whole slide image (WSI) refers to a type of high-resolution scanned tissue image, which is extensively employed in computer-assisted diagnosis (CAD). The extremely high resolution and limited availability of region-level annotations make…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Ruijie Zhang , Qiaozhe Zhang , Yingzhuang Liu , Hao Xin , Yan Liu , Xinggang Wang

Pathological image analysis is an important process for detecting abnormalities such as cancer from cell images. However, since the image size is generally very large, the cost of providing detailed annotations is high, which makes it…

Computer Vision and Pattern Recognition · Computer Science 2023-04-10 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Akihiko Yoshizawa , Tetsuo Ushiku , Masashi Fukayama , Masanobu Kitagawa , Masaru Kitsuregawa , Tatsuya Harada

Immune repertoire classification, a typical multiple instance learning (MIL) problem, is a frontier research topic in computational biology that makes transformative contributions to new vaccines and immune therapies. However, the…

Machine Learning · Computer Science 2023-08-01 Mingcai Chen , Yu Zhao , Zhonghuang Wang , Bing He , Jianhua Yao

This paper introduces MAD-MIL, a Multi-head Attention-based Deep Multiple Instance Learning model, designed for weakly supervised Whole Slide Images (WSIs) classification in digital pathology. Inspired by the multi-head attention mechanism…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Hassan Keshvarikhojasteh , Josien Pluim , Mitko Veta

Early diagnosis of lung cancer is a key intervention for the treatment of lung cancer computer aided diagnosis (CAD) can play a crucial role. However, most published CAD methods treat lung cancer diagnosis as a lung nodule classification…

Image and Video Processing · Electrical Eng. & Systems 2022-10-12 Junhua Chen , Haiyan Zeng , Chong Zhang , Zhenwei Shi , Andre Dekker , Leonard Wee , Inigo Bermejo

Aerial scenes are more complicated in terms of object distribution and spatial arrangement than natural scenes due to the bird view, and thus remain challenging to learn discriminative scene representation. Recent solutions design…

Computer Vision and Pattern Recognition · Computer Science 2022-05-30 Jingjun Yi , Beichen Zhou

Multiple Instance Learning (MIL) is a popular weakly-supervised method for various applications, with a particular interest in histological whole slide image (WSI) classification. Due to the gigapixel resolution of WSI, applications of MIL…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Wenhui Zhu , Peijie Qiu , Xiwen Chen , Zhangsihao Yang , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang