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We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

Learning disentangled representations with variational autoencoders (VAEs) is often attributed to the regularisation component of the loss. In this work, we highlight the interaction between data and the reconstruction term of the loss as…

Machine Learning · Computer Science 2023-10-27 Nathan Michlo , Richard Klein , Steven James

Variational Auto-encoders (VAEs) have been very successful as methods for forming compressed latent representations of complex, often high-dimensional, data. In this paper, we derive an alternative variational lower bound from the one…

Machine Learning · Computer Science 2019-03-20 Shuyu Lin , Ronald Clark , Robert Birke , Niki Trigoni , Stephen Roberts

Masked autoencoder (MAE), a simple and effective self-supervised learning framework based on the reconstruction of masked image regions, has recently achieved prominent success in a variety of vision tasks. Despite the emergence of…

Machine Learning · Computer Science 2023-06-09 Lingjing Kong , Martin Q. Ma , Guangyi Chen , Eric P. Xing , Yuejie Chi , Louis-Philippe Morency , Kun Zhang

Recent work has shown that Variational Autoencoders (VAEs) can be used to upper-bound the information rate-distortion (R-D) function of images, i.e., the fundamental limit of lossy image compression. In this paper, we report an improved…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Zhihao Duan , Jack Ma , Jiangpeng He , Fengqing Zhu

Variational autoencoder (VAE) is one of the most common techniques in the field of medical image generation, where this architecture has shown advanced researchers in recent years and has developed into various architectures. VAE has…

Machine Learning · Computer Science 2024-11-13 Khadija Rais , Mohamed Amroune , Abdelmadjid Benmachiche , Mohamed Yassine Haouam

Variational autoencoders (VAEs) have recently been used for unsupervised disentanglement learning of complex density distributions. Numerous variants exist to encourage disentanglement in latent space while improving reconstruction.…

Machine Learning · Statistics 2022-06-10 Kenneth Ezukwoke , Anis Hoayek , Mireille Batton-Hubert , Xavier Boucher

Inverse problems aim to determine model parameters of a mathematical problem from given observational data. Neural networks can provide an efficient tool to solve these problems. In the context of Bayesian inverse problems, Uncertainty…

Numerical Analysis · Mathematics 2025-09-16 Andrea Tonini , Tan Bui-Thanh , Francesco Regazzoni , Luca Dede' , Alfio Quarteroni

We propose the first general PAC-Bayesian generalization bounds for adversarial robustness, that estimate, at test time, how much a model will be invariant to imperceptible perturbations in the input. Instead of deriving a worst-case…

Machine Learning · Computer Science 2021-10-28 Paul Viallard , Guillaume Vidot , Amaury Habrard , Emilie Morvant

Variational inference (VI) is widely used for approximate inference in Bayesian machine learning. In addition to this practical success, generalization bounds for variational inference and related algorithms have been developed, mostly…

Machine Learning · Computer Science 2025-02-19 Yadi Wei , Roni Khardon

By leveraging experience from previous tasks, meta-learning algorithms can achieve effective fast adaptation ability when encountering new tasks. However it is unclear how the generalization property applies to new tasks. Probably…

Machine Learning · Computer Science 2021-02-09 Tianyu Liu , Jie Lu , Zheng Yan , Guangquan Zhang

The Variational Auto-Encoder (VAE) is a simple, efficient, and popular deep maximum likelihood model. Though usage of VAEs is widespread, the derivation of the VAE is not as widely understood. In this tutorial, we will provide an overview…

Machine Learning · Computer Science 2020-07-02 Ronald Yu

Although the variational autoencoder (VAE) and its conditional extension (CVAE) are capable of state-of-the-art results across multiple domains, their precise behavior is still not fully understood, particularly in the context of data (like…

Machine Learning · Computer Science 2023-06-16 Yijia Zheng , Tong He , Yixuan Qiu , David Wipf

We consider a variational autoencoder (VAE) for binary data. Our main innovations are an interpretable lower bound for its training objective, a modified initialization and architecture of such a VAE that leads to faster training, and a…

Machine Learning · Computer Science 2020-03-27 Robert Sicks , Ralf Korn , Stefanie Schwaar

In Bayesian machine learning, the posterior distribution is typically computationally intractable, hence variational inference is often required. In this approach, an evidence lower bound on the log likelihood of data is maximized during…

Machine Learning · Computer Science 2019-07-23 Stephen Odaibo

Generalised Bayesian learning algorithms are increasingly popular in machine learning, due to their PAC generalisation properties and flexibility. The present paper aims at providing a self-contained survey on the resulting PAC-Bayes…

Machine Learning · Statistics 2020-02-06 Benjamin Guedj

Anomaly detection without priors of the anomalies is challenging. In the field of unsupervised anomaly detection, traditional auto-encoder (AE) tends to fail based on the assumption that by training only on normal images, the model will not…

Computer Vision and Pattern Recognition · Computer Science 2024-08-15 Yajie Cui , Zhaoxiang Liu , Shiguo Lian

We combine conditional variational autoencoders (VAE) with adversarial censoring in order to learn invariant representations that are disentangled from nuisance/sensitive variations. In this method, an adversarial network attempts to…

Machine Learning · Computer Science 2018-05-22 Ye Wang , Toshiaki Koike-Akino , Deniz Erdogmus

Is there really much more to say about sparse autoencoders (SAEs)? Autoencoders in general, and SAEs in particular, represent deep architectures that are capable of modeling low-dimensional latent structure in data. Such structure could…

Machine Learning · Computer Science 2025-06-09 Yin Lu , Xuening Zhu , Tong He , David Wipf

Variational autoencoder (VAE) is a very successful generative model whose key element is the so called amortized inference network, which can perform test time inference using a single feed forward pass. Unfortunately, this comes at the…

Machine Learning · Computer Science 2021-02-08 Minyoung Kim , Vladimir Pavlovic