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We propose a new type of diffuse interface model describing the evolution of a tumor mass under the effects of a chemical substance (e.g., a nutrient or a drug). The process is described by utilizing the variables $\varphi$, an order…

Analysis of PDEs · Mathematics 2022-02-23 Elisabetta Rocca , Giulio Schimperna , Andrea Signori

The global-in-time existence of weak solutions to a degenerate Cahn-Hilliard cross-diffusion system with singular potential in a bounded domain with no-flux boundary conditions is proved. The model consists of two coupled parabolic…

Analysis of PDEs · Mathematics 2024-01-11 Ansgar Jüngel , Yue Li

In this work, we develop a structure-preserving numerical scheme for a Cahn-Hilliard-Darcy model that describes tumor growth in a fluid-saturated porous medium. First, we derive a physically consistent model from the general framework…

Numerical Analysis · Mathematics 2026-05-22 Daniel Acosta-Soba , Francisco Guillén-González , J. Rafael Rodríguez-Galván

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein

We study a Navier-Stokes/Cahn-Hilliard system modeling the evolution of a compressible binary mixture of viscous fluids undergoing phase separation. The novelty of this work is a free energy potential including the physically relevant…

Analysis of PDEs · Mathematics 2025-06-10 Danica Basarić , Andrea Giorgini

Using basic thermodynamic principles we derive a Cahn--Hilliard--Darcy model for tumour growth including nutrient diffusion, chemotaxis, active transport, adhesion, apoptosis and proliferation. The model generalises earlier models and in…

Analysis of PDEs · Mathematics 2016-06-06 Harald Garcke , Kei Fong Lam , Emanuel Sitka , Vanessa Styles

The global existence of bounded weak solutions to a diffusion system modeling biofilm growth is proven. The equations consist of a reaction-diffusion equation for the substrate concentration and a fourth-order Cahn-Hilliard-type equation…

Analysis of PDEs · Mathematics 2023-07-20 Christoph Helmer , Ansgar Jüngel

A typical phase field approach for describing phase separation and coarsening phenomena in alloys is the Cahn-Hilliard model. This model has been generalized to the so-called Cahn-Larch\'e system by combining it with elasticity to capture…

Analysis of PDEs · Mathematics 2015-02-23 Christian Heinemann , Christiane Kraus

We analyze a diffuse interface model that describes the dynamics of incompressible two-phase flows influenced by interactions with a soluble chemical substance, encompassing the chemotaxis effect, mass transport, and reactions. In the…

Analysis of PDEs · Mathematics 2026-01-13 Andrea Giorgini , Jingning He , Hao Wu

In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalization of a phase field…

Analysis of PDEs · Mathematics 2019-06-27 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

We study the well-posedness of a coupled Cahn-Hilliard-Stokes-Darcy system which is a diffuse-interface model for essentially immiscible two phase incompressible flows with matched density in a karstic geometry. Existence of finite energy…

Analysis of PDEs · Mathematics 2014-05-22 Daozhi Han , Xiaoming Wang , Hao WU

We introduce a new diffuse interface model for tumour growth in the presence of a nutrient, in which we take into account mechanical effects and reversible tissue damage. The highly nonlinear PDEs system mainly consists of a Cahn-Hilliard…

Analysis of PDEs · Mathematics 2025-10-09 Giulia Cavalleri

We prove existence of weak solutions to a diffuse interface model describing the flow of a fluid through a deformable porous medium consisting of two phases. The system non-linearly couples Biot's equations for poroelasticity, including…

Analysis of PDEs · Mathematics 2024-08-27 Helmut Abels , Harald Garcke , Jonas Haselböck

This paper investigates a Cahn-Hilliard-Swift-Hohenberg system, focusing on a three-species chemical mixture subject to physical constraints on volume fractions. The resulting system leads to complex patterns involving a separation into…

Analysis of PDEs · Mathematics 2024-10-02 Harald Garcke , Kei Fong Lam , Robert Nürnberg , Andrea Signori

A Maxwell-Stefan system for fluid mixtures with driving forces depending on Cahn-Hilliard-type chemical potentials is analyzed. The corresponding parabolic cross-diffusion equations contain fourth-order derivatives and are considered in a…

Analysis of PDEs · Mathematics 2022-05-16 Xiaokai Huo , Ansgar Jüngel , Athanasios E. Tzavaras

The diffusion driven by the gradient of the chemical potential (by the Fick/Darcy law) in deforming continua at large strains is formulated in the reference configuration with both the Fick/Darcy law and the capillarity gradient term…

Analysis of PDEs · Mathematics 2019-04-02 Tomáš Roubíček

We consider a diffuse interface model for tumor growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation, which models a tumor growing in the presence of a nutrient species and surrounded by…

Analysis of PDEs · Mathematics 2017-05-04 Harald Garcke , Kei Fong Lam

We consider a class of six-order Cahn-Hilliard equations with logarithmic type potential. This system is closely connected with some important phase-field models relevant in different applications, for instance, the functionalized…

Analysis of PDEs · Mathematics 2023-07-28 Giulio Schimperna , Hao Wu

We investigate the Cahn-Hilliard equation with nonlinear diffusion and non-degenerate mobility modeling phase separation phenomena in complex systems (e.g., crystals and polymers). Previous results in the literature on this model relied on…

Analysis of PDEs · Mathematics 2025-10-10 Monica Conti , Stefania Gatti , Andrea Giorgini , Giulio Schimperna

We consider a class of Cahn-Hilliard equation that models phase separation process of binary mixtures involving nontrivial boundary interactions in a bounded domain with non-permeable wall. The system is characterized by certain dynamic…

Analysis of PDEs · Mathematics 2023-07-28 Takeshi Fukao , Hao Wu