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Clinical oncology generates vast, unstructured data that often contain inconsistencies, missing information, and ambiguities, making it difficult to extract reliable insights for data-driven decision-making. General-purpose large language…

Computation and Language · Computer Science 2025-03-12 Morteza Rohanian , Tarun Mehra , Nicola Miglino , Farhad Nooralahzadeh , Michael Krauthammer , Andreas Wicki

Control theory has seen recently impactful applications in network science, especially in connections with applications in network medicine. A key topic of research is that of finding minimal external interventions that offer control over…

Molecular Networks · Quantitative Biology 2020-07-10 Victor-Bogdan Popescu , Krishna Kanhaiya , Iulian Năstac , Eugen Czeizler , Ion Petre

This research presents an innovative approach to cancer diagnosis and prediction using explainable Artificial Intelligence (XAI) and deep learning techniques. With cancer causing nearly 10 million deaths globally in 2020, early and accurate…

Artificial Intelligence · Computer Science 2024-12-24 Badaru I. Olumuyiwa , The Anh Han , Zia U. Shamszaman

Accurate segmentation of brain tumors is vital for diagnosis, surgical planning, and treatment monitoring. Deep learning has advanced on benchmarks, but two issues limit clinical use: no uncertainty estimates for errors and no segmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Andrew Zhou

Medical image classification is crucial for supporting healthcare professionals in decision-making and training. While Convolutional Neural Networks (CNNs) have traditionally dominated this field, Transformer-based models are gaining…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 S. Park , J. Kim

There is a widening recognition that cancer cells are products of complex developmental processes. Carcinogenesis and metastasis formation are increasingly described as systems-level, network phenomena. Here we propose that malignant…

Molecular Networks · Quantitative Biology 2013-09-18 David M. Gyurko , Daniel V. Veres , Dezso Modos , Katalin Lenti , Tamas Korcsmaros , Peter Csermely

Transfer learning has been shown to be effective in many applications in which training data for the target problem are limited but data for a related (source) problem are abundant. In this paper, we apply transfer learning to the…

Quantitative Methods · Quantitative Biology 2020-05-20 Yitan Zhu , Thomas Brettin , Yvonne A. Evrard , Alexander Partin , Fangfang Xia , Maulik Shukla , Hyunseung Yoo , James H. Doroshow , Rick Stevens

This study investigates the application of quantum neural networks (QNNs) for propensity score estimation to address selection bias in comparing survival outcomes between laparoscopic and open surgical techniques in a cohort of 1177…

Quantum Physics · Physics 2025-06-26 Vojtěch Novák , Ivan Zelinka , Lenka Přibylová , Lubomír Martínek

Introduction: The present study on the development and evaluation of an automated brain tumor segmentation technique based on deep learning using the 3D U-Net model. Objectives: The objective is to leverage state-of-the-art convolutional…

Image and Video Processing · Electrical Eng. & Systems 2024-04-10 Suman Sourabh , Murugappan Valliappan , Narayana Darapaneni , Anwesh R P

Cancer is a complex disease that is characterized by uncontrolled growth and division of cells. It involves a complex interplay between genetic and environmental factors that lead to the initiation and progression of tumors. Recent advances…

Biomolecules · Quantitative Biology 2025-02-07 Reza Bozorgpour

In the cancer diagnosis pipeline, digital pathology plays an instrumental role in the identification, staging, and grading of malignant areas on biopsy tissue specimens. High resolution histology images are subject to high variance in…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Vasileios Magoulianitis , Catherine A. Alexander , C. -C. Jay Kuo

Cancer is a complex genetic disease involving uncontrolled cell growth and proliferation, and necessitates effective targeting of dysregulated cellular pathways underlying cancer progression. Multiple genetic and epigenetic alterations…

Other Quantitative Biology · Quantitative Biology 2026-01-28 Manish Kumar

Oncolytic viral therapy (OVT) is an emerging precision therapy for aggressive and recurrent cancers. However, its clinical efficacy is hindered by the complexity of tumor-virus-immune interactions and the lack of predictive models for…

Quantitative Methods · Quantitative Biology 2026-03-11 Abicumaran Uthamacumaran , Juri Kiyokawa , Hiroaki Wakimoto

Cancers are complex adaptive diseases regulated by the nonlinear feedback systems between genetic instabilities, environmental signals, cellular protein flows, and gene regulatory networks. Understanding the cybernetics of cancer requires…

Other Quantitative Biology · Quantitative Biology 2022-08-30 Abicumaran Uthamacumaran , Hector Zenil

The goal of cancer immunotherapy is to boost a patient's immune response to a tumor. Yet, the design of an effective immunotherapy is complicated by various factors, including a potentially immunosuppressive tumor microenvironment,…

Tissues and Organs · Quantitative Biology 2017-06-29 Anna Konstorum , Anthony T. Vella , Adam J. Adler , Reinhard Laubenbacher

Data clustering has been widely used in data analysis and classification. In the present work, a method based on dynamic quantum clustering is proposed for the segmentation and analysis of brain tumor MRI. The results open the possibility…

Medical Physics · Physics 2021-07-27 Jacksson Sanchez , Miguel Martin Landrove

Accurate and robust cell nuclei classification is the cornerstone for a wider range of tasks in digital and Computational Pathology. However, most machine learning systems require extensive labeling from expert pathologists for each…

Quantitative Methods · Quantitative Biology 2016-12-05 Stefan Bauer , Nicolas Carion , Peter Schüffler , Thomas Fuchs , Peter Wild , Joachim M. Buhmann

Histopathological images contain rich phenotypic information that can be used to monitor underlying mechanisms contributing to diseases progression and patient survival outcomes. Recently, deep learning has become the mainstream…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Chetan L. Srinidhi , Ozan Ciga , Anne L. Martel

Comparative diagnostic in brain tumor evaluation makes possible to use the available information of a medical center to compare similar cases when a new patient is evaluated. By leveraging Artificial Intelligence models, the proposed system…

Image and Video Processing · Electrical Eng. & Systems 2024-05-31 Guillermo Iglesias , Edgar Talavera , Jesús Troya Garcìa , Alberto Díaz-Álvarez , Miguel Gracía-Remesal

Brain tumors are one of the most common and dangerous neurological diseases which require a timely and correct diagnosis to provide the right treatment procedures. Even with the promotion of magnetic resonance imaging (MRI), the process of…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Md. Srabon Chowdhury , Syeda Fahmida Tanzim , Sheekar Banerjee , Ishtiak Al Mamoon , AKM Muzahidul Islam