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Related papers: Knowledge-informed Molecular Learning: A Survey on…

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Deep learning is transforming many areas in science, and it has great potential in modeling molecular systems. However, unlike the mature deployment of deep learning in computer vision and natural language processing, its development in…

Computational Physics · Physics 2021-03-19 Jun Zhang , Yao-Kun Lei , Zhen Zhang , Junhan Chang , Maodong Li , Xu Han , Lijiang Yang , Yi Isaac Yang , Yi Qin Gao

Research in machine learning is at a turning point. While supervised deep learning has conquered the field at a breathtaking pace and demonstrated the ability to solve inference problems with unprecedented accuracy, it still does not quite…

Machine Learning · Computer Science 2020-12-22 Alexander Sagel , Amit Sahu , Stefan Matthes , Holger Pfeifer , Tianming Qiu , Harald Rueß , Hao Shen , Julian Wörmann

Molecular property prediction integrates quantum chemistry, cheminformatics, and deep learning to connect molecular structure with physicochemical and biological behavior. This survey traces four complementary paradigms, including Quantum,…

Deep learning has significantly advanced molecular modeling and design, enabling efficient understanding and discovery of novel molecules. In particular, large language models (LLMs) introduce a fresh research paradigm to tackle scientific…

Machine Learning · Computer Science 2025-01-06 Pengfei Liu , Jun Tao , Zhixiang Ren

Molecules and materials are the foundation for the development of modern advanced industries such as energy storage systems and semiconductor devices. However, traditional trial-and-error methods or theoretical calculations are highly…

Artificial intelligence has demonstrated immense potential in scientific research. Within molecular science, it is revolutionizing the traditional computer-aided paradigm, ushering in a new era of deep learning. With recent progress in…

Biomolecules · Quantitative Biology 2024-03-22 Yi Xiao , Xiangxin Zhou , Qiang Liu , Liang Wang

Recently supervised machine learning has been ascending in providing new predictive approaches for chemical, biological and materials sciences applications. In this Perspective we focus on the interplay of machine learning algorithm with…

The optimal design of compounds through manipulating properties at the molecular level is often the key to considerable scientific advances and improved process systems performance. This paper highlights key trends, challenges, and…

Biomolecules · Quantitative Biology 2020-07-13 Abdulelah S. Alshehri , Rafiqul Gani , Fengqi You

Large Language Models (LLMs) inherently encode a wealth of knowledge within their parameters through pre-training on extensive corpora. While prior research has delved into operations on these parameters to manipulate the underlying…

Computation and Language · Computer Science 2024-05-09 Ming Zhong , Chenxin An , Weizhu Chen , Jiawei Han , Pengcheng He

With the development of computer-assisted techniques, research communities including biochemistry and deep learning have been devoted into the drug discovery field for over a decade. Various applications of deep learning have drawn great…

Machine Learning · Computer Science 2023-03-07 Wenhao Hu , Yingying Liu , Xuanyu Chen , Wenhao Chai , Hangyue Chen , Hongwei Wang , Gaoang Wang

In this review, we highlight recent developments in the application of machine learning for molecular modeling and simulation. After giving a brief overview of the foundations, components, and workflow of a typical supervised learning…

Data Analysis, Statistics and Probability · Physics 2019-02-21 Mojtaba Haghighatlari , Johannes Hachmann

Cancer remains one of the most challenging diseases to treat in the medical field. Machine learning has enabled in-depth analysis of rich multi-omics profiles and medical imaging for cancer diagnosis and prognosis. Despite these…

Machine Learning · Computer Science 2024-01-15 Lingchao Mao , Hairong Wang , Leland S. Hu , Nhan L Tran , Peter D Canoll , Kristin R Swanson , Jing Li

In the era of deep learning, modeling for most NLP tasks has converged to several mainstream paradigms. For example, we usually adopt the sequence labeling paradigm to solve a bundle of tasks such as POS-tagging, NER, Chunking, and adopt…

Computation and Language · Computer Science 2022-05-31 Tianxiang Sun , Xiangyang Liu , Xipeng Qiu , Xuanjing Huang

Transfer learning has recently become the dominant paradigm of machine learning. Pre-trained models fine-tuned for downstream tasks achieve better performance with fewer labelled examples. Nonetheless, it remains unclear how to develop…

Machine Learning · Computer Science 2024-01-30 Jonas Pfeiffer , Sebastian Ruder , Ivan Vulić , Edoardo Maria Ponti

Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for a machine learning revolution and have already been profoundly impacted by the…

Chemical Physics · Physics 2019-11-11 Frank Noé , Alexandre Tkatchenko , Klaus-Robert Müller , Cecilia Clementi

Imitation learning has emerged as a powerful paradigm in robot manipulation, yet its generalization capability remains constrained by object-specific dependencies in limited expert demonstrations. To address this challenge, we propose…

Robotics · Computer Science 2025-06-27 Zhuochen Miao , Jun Lv , Hongjie Fang , Yang Jin , Cewu Lu

There is an increasing interest in the use of Deep Learning (DL) based methods as a supporting analytical framework in oncology. However, most direct applications of DL will deliver models with limited transparency and explainability, which…

Quantitative Methods · Quantitative Biology 2023-01-26 Magdalena Wysocka , Oskar Wysocki , Marie Zufferey , Dónal Landers , André Freitas

The success of deep learning algorithms generally depends on large-scale data, while humans appear to have inherent ability of knowledge transfer, by recognizing and applying relevant knowledge from previous learning experiences when…

Machine Learning · Computer Science 2022-01-19 Junguang Jiang , Yang Shu , Jianmin Wang , Mingsheng Long

Integrating knowledge across different domains is an essential feature of human learning. Learning paradigms such as transfer learning, meta-learning, and multi-task learning reflect the human learning process by exploiting the prior…

Machine Learning · Computer Science 2024-10-17 Richa Upadhyay , Ronald Phlypo , Rajkumar Saini , Marcus Liwicki

Reinforcement learning is a learning paradigm for solving sequential decision-making problems. Recent years have witnessed remarkable progress in reinforcement learning upon the fast development of deep neural networks. Along with the…

Machine Learning · Computer Science 2023-07-06 Zhuangdi Zhu , Kaixiang Lin , Anil K. Jain , Jiayu Zhou
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