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Artificial Intelligence in Medicine has made significant progress with emerging applications in medical imaging, patient care, and other areas. While these applications have proven successful in retrospective studies, very few of them were…

Artificial Intelligence · Computer Science 2023-08-11 Nicoletta Prentzas , Antonis Kakas , Constantinos S. Pattichis

With an increase in deep learning-based methods, the call for explainability of such methods grows, especially in high-stakes decision making areas such as medical image analysis. This survey presents an overview of eXplainable Artificial…

Image and Video Processing · Electrical Eng. & Systems 2022-05-06 Bas H. M. van der Velden , Hugo J. Kuijf , Kenneth G. A. Gilhuijs , Max A. Viergever

Explainable AI (XAI) techniques are necessary to help clinicians make sense of AI predictions and integrate predictions into their decision-making workflow. In this work, we conduct a survey study to understand clinician preference among…

Computation and Language · Computer Science 2025-08-28 Jun Hou , Lucy Lu Wang

In recent years, AI systems in the medical domain have advanced significantly. However, despite outperforming humans, they are rarely used in practice since it is often not clear how they make their decisions. Optimal explanation and…

Human-Computer Interaction · Computer Science 2026-05-06 Julia Wagner , Tim Schlippe

Despite promising developments in Explainable Artificial Intelligence, the practical value of XAI methods remains under-explored and insufficiently validated in real-world settings. Robust and context-aware evaluation is essential, not only…

Human-Computer Interaction · Computer Science 2025-06-18 Ivania Donoso-Guzmán , Kristýna Sirka Kacafírková , Maxwell Szymanski , An Jacobs , Denis Parra , Katrien Verbert

Explainable Artificial Intelligence (XAI) is essential for building advanced machine learning-powered applications, especially in critical domains such as medical diagnostics or autonomous driving. Legal, business, and ethical requirements…

Human-Computer Interaction · Computer Science 2024-10-17 Tobias Labarta , Elizaveta Kulicheva , Ronja Froelian , Christian Geißler , Xenia Melman , Julian von Klitzing

XAI refers to the techniques and methods for building AI applications which assist end users to interpret output and predictions of AI models. Black box AI applications in high-stakes decision-making situations, such as medical domain have…

The remarkable success of deep learning has prompted interest in its application to medical imaging diagnosis. Even though state-of-the-art deep learning models have achieved human-level accuracy on the classification of different types of…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Cristiano Patrício , João C. Neves , Luís F. Teixeira

Explainable artificial intelligence (XAI) has become increasingly important in biomedical image analysis to promote transparency, trust, and clinical adoption of DL models. While several surveys have reviewed XAI techniques, they often lack…

Computer Vision and Pattern Recognition · Computer Science 2025-07-11 Getamesay Haile Dagnaw , Yanming Zhu , Muhammad Hassan Maqsood , Wencheng Yang , Xingshuai Dong , Xuefei Yin , Alan Wee-Chung Liew

The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

The increasing demand for transparent and reliable models, particularly in high-stakes decision-making areas such as medical image analysis, has led to the emergence of eXplainable Artificial Intelligence (XAI). Post-hoc XAI techniques,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-18 Junlin Hou , Sicen Liu , Yequan Bie , Hongmei Wang , Andong Tan , Luyang Luo , Hao Chen

Nowadays Artificial Intelligence (AI) has become a fundamental component of healthcare applications, both clinical and remote, but the best performing AI systems are often too complex to be self-explaining. Explainable AI (XAI) techniques…

Machine Learning · Computer Science 2022-09-15 Flavio Di Martino , Franca Delmastro

More recently, Explainable Artificial Intelligence (XAI) research has shifted to focus on a more pragmatic or naturalistic account of understanding, that is, whether the stakeholders understand the explanation. This point is especially…

Human-Computer Interaction · Computer Science 2021-08-05 Janet Hui-wen Hsiao , Hilary Hei Ting Ngai , Luyu Qiu , Yi Yang , Caleb Chen Cao

Explainable Artificial Intelligence (XAI) techniques are used to provide transparency to complex, opaque predictive models. However, these techniques are often designed for image and text data, and it is unclear how fit-for-purpose they are…

Computers and Society · Computer Science 2024-10-18 Mythreyi Velmurugan , Chun Ouyang , Yue Xu , Renuka Sindhgatta , Bemali Wickramanayake , Catarina Moreira

Last years have been characterized by an upsurge of opaque automatic decision support systems, such as Deep Neural Networks (DNNs). Although they have great generalization and prediction skills, their functioning does not allow obtaining…

As the field of healthcare increasingly adopts artificial intelligence, it becomes important to understand which types of explanations increase transparency and empower users to develop confidence and trust in the predictions made by…

Artificial Intelligence · Computer Science 2025-05-16 Felix Liedeker , Olivia Sanchez-Graillet , Moana Seidler , Christian Brandt , Jörg Wellmer , Philipp Cimiano

The absence of transparency and explainability hinders the clinical adoption of Machine learning (ML) algorithms. Although various methods of explainable artificial intelligence (XAI) have been suggested, there is a lack of literature that…

Machine Learning · Computer Science 2023-06-22 Aida Brankovic , David Cook , Jessica Rahman , Wenjie Huang , Sankalp Khanna

In recent years, Explainable AI (xAI) attracted a lot of attention as various countries turned explanations into a legal right. xAI allows for improving models beyond the accuracy metric by, e.g., debugging the learned pattern and…

Software Engineering · Computer Science 2022-10-05 Mohamed Karim Belaid , Eyke Hüllermeier , Maximilian Rabus , Ralf Krestel

Artificial intelligence models encounter significant challenges due to their black-box nature, particularly in safety-critical domains such as healthcare, finance, and autonomous vehicles. Explainable Artificial Intelligence (XAI) addresses…

Artificial Intelligence · Computer Science 2025-03-14 Melkamu Mersha , Khang Lam , Joseph Wood , Ali AlShami , Jugal Kalita

Artificial intelligence (AI) models are increasingly finding applications in the field of medicine. Concerns have been raised about the explainability of the decisions that are made by these AI models. In this article, we give a systematic…

Machine Learning · Computer Science 2023-04-12 Subrato Bharati , M. Rubaiyat Hossain Mondal , Prajoy Podder
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