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Autism Spectrum Disorder (ASD) is a diverse collection of neurobiological conditions marked by challenges in social communication and reciprocal interactions, as well as repetitive and stereotypical behaviors. Atypical behavior patterns in…

Computer Vision and Pattern Recognition · Computer Science 2024-07-15 Abid Ali , Mahmoud Ali , Jean-Marc Odobez , Camilla Barbini , Séverine Dubuisson , Francois Bremond , Susanne Thümmler

A common neurodegenerative disease, Alzheimer's disease requires a precise diagnosis and efficient treatment, particularly in light of escalating healthcare expenses and the expanding use of artificial intelligence in medical diagnostics.…

Image and Video Processing · Electrical Eng. & Systems 2025-05-21 Soyabul Islam Lincoln , Mirza Mohd Shahriar Maswood

Lesion detection in brain Magnetic Resonance Images (MRIs) remains a challenging task. MRIs are typically read and interpreted by domain experts, which is a tedious and time-consuming process. Recently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2022-02-01 Marcel Bengs , Finn Behrendt , Max-Heinrich Laves , Julia Krüger , Roland Opfer , Alexander Schlaefer

Mild cognitive impairment(MCI) is a precursor of Alzheimer's disease(AD), and the detection of MCI is of great clinical significance. Analyzing the structural brain networks of patients is vital for the recognition of MCI. However, the…

Neurons and Cognition · Quantitative Biology 2022-08-19 Heng Kong , Shuqiang Wang

State-of-the-art anomalous sound detection (ASD) systems in domain-shifted conditions rely on projecting audio signals into an embedding space and using distance-based outlier detection to compute anomaly scores. One of the major…

Audio and Speech Processing · Electrical Eng. & Systems 2025-10-29 Kevin Wilkinghoff , Haici Yang , Janek Ebbers , François G. Germain , Gordon Wichern , Jonathan Le Roux

Unsupervised Anomaly Detection (UAD) methods rely on healthy data distributions to identify anomalies as outliers. In brain MRI, a common approach is reconstruction-based UAD, where generative models reconstruct healthy brain MRIs, and…

Image and Video Processing · Electrical Eng. & Systems 2024-07-18 Finn Behrendt , Debayan Bhattacharya , Robin Mieling , Lennart Maack , Julia Krüger , Roland Opfer , Alexander Schlaefer

We propose a novel optimization framework to predict clinical severity from resting state fMRI (rs-fMRI) data. Our model consists of two coupled terms. The first term decomposes the correlation matrices into a sparse set of representative…

Neurons and Cognition · Quantitative Biology 2024-11-25 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart H. Mostofsky , Archana Venkataraman

Children with Autism Spectrum Disorder (ASD) frequently exhibit comorbid anxiety, which contributes to impairment and requires treatment. Therefore, it is critical to investigate co-occurring autism and anxiety with functional imaging tools…

Neurons and Cognition · Quantitative Biology 2024-07-02 Peiyu Duan , Nicha C. Dvornek , Jiyao Wang , Jeffrey Eilbott , Yuexi Du , Denis G. Sukhodolsky , James S. Duncan

Anomaly detection in time series data, to identify points that deviate from normal behaviour, is a common problem in various domains such as manufacturing, medical imaging, and cybersecurity. Recently, Generative Adversarial Networks (GANs)…

Machine Learning · Computer Science 2025-05-27 Md Abul Bashar , Richi Nayak

The application of machine learning algorithms to the diagnosis and analysis of Alzheimer's disease (AD) from multimodal neuroimaging data is a current research hotspot. It remains a formidable challenge to learn brain region information…

Image and Video Processing · Electrical Eng. & Systems 2022-08-11 Yongcheng Zong , Changhong Jing , Qiankun Zuo

Machine learning (ML) algorithms are optimized for the distribution represented by the training data. For outlier data, they often deliver predictions with equal confidence, even though these should not be trusted. In order to deploy…

Image and Video Processing · Electrical Eng. & Systems 2021-03-17 Milda Pocevičiūtė , Gabriel Eilertsen , Claes Lundström

Structural magnetic resonance imaging (sMRI) combined with deep learning has achieved remarkable progress in the prediction and diagnosis of Alzheimer's disease (AD). Existing studies have used CNN and transformer to build a well-performing…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Zheng Yang , Yanteng Zhang , Xupeng Kou , Yang Liu , Chao Ren

Alzheimer's Disease (AD) is a neurodegenerative disease affecting millions of individuals across the globe. As the prevalence of this disease continues to rise, early diagnosis is crucial to improve clinical outcomes. Neural networks,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-06 Akshay Sunkara , Rajiv Morthala , Anav Jain , Srinjoy Ghose , Santosh Morthala

Magnetic Resonance Imaging (MRI) is a vital component of medical imaging. When compared to other image modalities, it has advantages such as the absence of radiation, superior soft tissue contrast, and complementary multiple sequence…

Image and Video Processing · Electrical Eng. & Systems 2021-05-06 Guang Yang , Jun Lv , Yutong Chen , Jiahao Huang , Jin Zhu

Recent advances in deep learning led to novel generative modeling techniques that achieve unprecedented quality in generated samples and performance in learning complex distributions in imaging data. These new models in medical image…

Computer Vision and Pattern Recognition · Computer Science 2018-06-15 Xiaoran Chen , Nick Pawlowski , Martin Rajchl , Ben Glocker , Ender Konukoglu

Deep unsupervised representation learning has recently led to new approaches in the field of Unsupervised Anomaly Detection (UAD) in brain MRI. The main principle behind these works is to learn a model of normal anatomy by learning to…

Image and Video Processing · Electrical Eng. & Systems 2020-04-09 Christoph Baur , Stefan Denner , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab

While graph convolution based methods have become the de-facto standard for graph representation learning, their applications to disease prediction tasks remain quite limited, particularly in the classification of neurodevelopmental and…

Computer Vision and Pattern Recognition · Computer Science 2023-11-17 Ibrahim Salim , A. Ben Hamza

Anomaly detection remains a challenging task in neuroimaging when little to no supervision is available and when lesions can be very small or with subtle contrast. Patch-based representation learning has shown powerful representation…

Image and Video Processing · Electrical Eng. & Systems 2023-04-18 Nicolas Pinon , Robin Trombetta , Carole Lartizien

Anomaly detection for Magnetic Resonance Images (MRIs) can be solved with unsupervised methods by learning the distribution of healthy images and identifying anomalies as outliers. In presence of an additional dataset of unlabelled data…

Machine Learning · Computer Science 2020-07-27 Alexandra-Ioana Albu , Alina Enescu , Luigi Malagò

Identifying objective neuroimaging biomarkers to forecast Alzheimer's disease (AD) progression is crucial for timely intervention. However, this task remains challenging due to the complex dysfunctions in the spatio-temporal characteristics…