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We describe a kernel of size 9k-8 for the NP-hard problem of computing the Tree Bisection and Reconnect (TBR) distance k between two unrooted binary phylogenetic trees. We achieve this by extending the existing portfolio of reduction rules…

Data Structures and Algorithms · Computer Science 2022-09-21 Steven Kelk , Simone Linz , Ruben Meuwese

The subtree prune-and-regraft (SPR) distance metric is a fundamental way of comparing evolutionary trees. It has wide-ranging applications, such as to study lateral genetic transfer, viral recombination, and Markov chain Monte Carlo…

Discrete Mathematics · Computer Science 2016-11-09 Chris Whidden , Frederick A. Matsen

In 2001 Allen and Steel showed that, if subtree and chain reduction rules have been applied to two unrooted phylogenetic trees, the reduced trees will have at most 28k taxa where k is the TBR (Tree Bisection and Reconnection) distance…

Data Structures and Algorithms · Computer Science 2021-04-13 Steven Kelk , Simone Linz

Phylogenetic networks are rooted directed acyclic graphs that represent evolutionary relationships between species whose past includes reticulation events such as hybridisation and horizontal gene transfer. To search the space of…

Combinatorics · Mathematics 2019-04-09 Jonathan Klawitter , Simone Linz

Phylogenetic trees are leaf-labelled trees used to model the evolution of species. Here we explore the practical impact of kernelization (i.e. data reduction) on the NP-hard problem of computing the TBR distance between two unrooted binary…

Data Structures and Algorithms · Computer Science 2023-08-21 Rim van Wersch , Steven Kelk , Simone Linz , Georgios Stamoulis

Recently it was shown that, if the subtree and chain reduction rules have been applied exhaustively to two unrooted phylogenetic trees, the reduced trees will have at most 15k-9 taxa where k is the TBR (Tree Bisection and Reconnection)…

Data Structures and Algorithms · Computer Science 2021-04-13 Steven Kelk , Simone Linz

The minimal number of rooted subtree prune and regraft (rSPR) operations needed to transform one phylogenetic tree into another one induces a metric on phylogenetic trees - the rSPR-distance. The rSPR-distance between two phylogenetic trees…

Combinatorics · Mathematics 2023-06-22 Jonathan Klawitter

Due to hybridization events in evolution, studying two different genes of a set of species may yield two related but different phylogenetic trees for the set of species. In this case, we want to measure the dissimilarity of the two trees.…

Data Structures and Algorithms · Computer Science 2017-07-28 Zhi-Zhong Chen , Eita Machida , Lusheng Wang

Phylogenetic trees are leaf-labelled trees, where the leaves correspond to extant species (taxa), and the internal vertices represent ancestral species. The evolutionary history of a set of species can be explained by more than one…

Data Structures and Algorithms · Computer Science 2016-09-07 Asish Mukhopadhyay , Puspal Bhabak

The subtree prune-and-regraft (SPR) distance metric is a fundamental way of comparing evolutionary trees. It has wide-ranging applications, such as to study lateral genetic transfer, viral recombination, and Markov chain Monte Carlo…

Data Structures and Algorithms · Computer Science 2017-11-07 Chris Whidden , Frederick A. Matsen

Maximum parsimony distance is a measure used to quantify the dissimilarity of two unrooted phylogenetic trees. It is NP-hard to compute, and very few positive algorithmic results are known due to its complex combinatorial structure. Here we…

Data Structures and Algorithms · Computer Science 2020-04-07 Mark Jones , Steven Kelk , Leen Stougie

The maximum agreement forest (MAF) problem in phylogenetics takes as input a set t >= 2 of binary phylogenetic trees T on the same set of taxa X. It asks for a partition of X into the smallest number of blocks such that the subtrees induced…

Combinatorics · Mathematics 2026-03-23 Steven Kelk , Ruben Meuwese , Leo van Iersel

A rearrangement operation makes a small graph-theoretical change to a phylogenetic network to transform it into another one. For unrooted phylogenetic trees and networks, popular rearrangement operations are tree bisection and reconnection…

Combinatorics · Mathematics 2023-06-22 Jonathan Klawitter

This paper introduces constNJ, the first algorithm for phylogenetic reconstruction of sets of trees with constrained pairwise rooted subtree-prune regraft (rSPR) distance. We are motivated by the problem of constructing sets of trees which…

Populations and Evolution · Quantitative Biology 2009-09-30 Frederick A. Matsen

Network rearrangement operations like SNPR (SubNet Prune and Regraft), a recent generalisation of rSPR (rooted Subtree Prune and Regraft), induce a metric on phylogenetic networks. To search the space of these networks one important…

Combinatorics · Mathematics 2018-10-17 Jonathan Klawitter

Understanding the evolution of a set of genes or species is a fundamental problem in evolutionary biology. The problem we study here takes as input a set of trees describing {possibly discordant} evolutionary scenarios for a given set of…

Data Structures and Algorithms · Computer Science 2019-07-10 Cedric Chauve , Mark Jones , Manuel Lafond , Céline Scornavacca , Mathias Weller

We give a 2-approximation algorithm for the Maximum Agreement Forest problem on two rooted binary trees. This NP-hard problem has been studied extensively in the past two decades, since it can be used to compute the rooted Subtree…

Data Structures and Algorithms · Computer Science 2018-11-15 Neil Olver , Frans Schalekamp , Suzanne van der Ster , Leen Stougie , Anke van Zuylen

We develop a time-optimal $O(mn^2)$-time algorithm to construct the subtree prune-regraft (SPR) graph on a collection of m phylogenetic trees with n leaves. This improves on the previous bound of $O(mn^3)$. Such graphs are used to better…

Data Structures and Algorithms · Computer Science 2017-04-28 Chris Whidden , Frederick A. Matsen

In this study, we investigate the problem of comparing gene trees reconciled with the same species tree using a novel semi-metric, called the Path-Label Reconciliation (PLR) dissimilarity measure. This approach not only quantifies…

In phylogenetics, distances are often used to measure the incongruence between a pair of phylogenetic trees that are reconstructed by different methods or using different regions of genome. Motivated by the maximum parsimony principle in…

Populations and Evolution · Quantitative Biology 2016-07-08 Steven Kelk , Mareike Fischer , Vincent Moulton , Taoyang Wu
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