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Molecular dynamics simulations are an important tool for describing the evolution of a chemical system with time. However, these simulations are inherently held back either by the prohibitive cost of accurate electronic structure theory…

Chemical Physics · Physics 2018-12-20 Michael Gastegger , Philipp Marquetand

Models trained in the context of continual learning (CL) should be able to learn from a stream of data over an undefined period of time. The main challenges herein are: 1) maintaining old knowledge while simultaneously benefiting from it…

Neural and Evolutionary Computing · Computer Science 2019-12-03 Oleksiy Ostapenko , Mihai Puscas , Tassilo Klein , Patrick Jähnichen , Moin Nabi

Genome-Scale Metabolic Models (GEMs) describe the interactions between genes, proteins, and the biochemical reactions that underpin an organism's metabolism aiming to computationally simulate functions at the cellular level. While many…

An integrated computational framework is introduced to study complex engineering systems through physics-based ensemble simulations on heterogeneous supercomputers. The framework is primarily designed for the quantitative assessment of…

Computational Engineering, Finance, and Science · Computer Science 2022-02-08 Kazuki Maeda , Thiago Teixeira , Jonathan M. Wang , Jeffrey M. Hokanson , Caetano Melone , Mario Di Renzo , Steve Jones , Javier Urzay , Gianluca Iaccarino

In drug discovery, knowledge of the graph structure of chemical compounds is essential. Many thousands of scientific articles in chemistry and pharmaceutical sciences have investigated chemical compounds, but in cases the details of the…

Machine Learning · Statistics 2020-09-16 Martijn Oldenhof , Adam Arany , Yves Moreau , Jaak Simm

While trade-offs between modeling effort and model accuracy remain a major concern with system identification, resorting to data-driven methods often leads to a complete disregard for physical plausibility. To address this issue, we propose…

Systems and Control · Electrical Eng. & Systems 2022-08-23 Oliver Schön , Ricarda-Samantha Götte , Julia Timmermann

Turbulent flow simulation plays a crucial role in various applications, including aircraft and ship design, industrial process optimization, and weather prediction. In this paper, we propose an advanced data-driven method for simulating…

Fluid Dynamics · Physics 2023-06-27 Duc Minh Nguyen , Minh Chau Vu , Tuan Anh Nguyen , Tri Huynh , Nguyen Tri Nguyen , Truong Son Hy

We introduce mesoscopic and macroscopic model equations of chemotaxis with anomalous subdiffusion for modelling chemically directed transport of biological organisms in changing chemical environments with diffusion hindered by traps or…

Dynamical Systems · Mathematics 2012-12-03 T. A. M. Langlands , B. I. Henry

Accurately predicting molecular properties is a challenging but essential task in drug discovery. Recently, many mono-modal deep learning methods have been successfully applied to molecular property prediction. However, the inherent…

Machine Learning · Computer Science 2024-09-16 Xiaohua Lu , Liangxu Xie , Lei Xu , Rongzhi Mao , Shan Chang , Xiaojun Xu

Computational systems and methods are often being used in biological research, including the understanding of cancer and the development of treatments. Simulations of tumor growth and its response to different drugs are of particular…

Probabilistic graphical models (PGMs) are widely used to discover latent structure in data, but their success hinges on selecting an appropriate model design. In practice, model specification is difficult and often requires iterative…

Machine Learning · Computer Science 2026-04-08 Kevin Zhang , Yixin Wang

Deep learning algorithms provide a new paradigm to study high-dimensional dynamical behaviors, such as those in fusion plasma systems. Development of novel model reduction methods, coupled with detection of abnormal modes with plasma…

Computational Physics · Physics 2024-04-29 Zhe Bai , Xishuo Wei , William Tang , Leonid Oliker , Zhihong Lin , Samuel Williams

Deep learning has shown great potential for modeling the physical dynamics of complex particle systems such as fluids. Existing approaches, however, require the supervision of consecutive particle properties, including positions and…

Machine Learning · Computer Science 2022-06-22 Shanyan Guan , Huayu Deng , Yunbo Wang , Xiaokang Yang

Modelling the sudden depressurisation of superheated liquids through nozzles is a challenge because the pressure drop causes rapid flash boiling of the liquid. The resulting jet usually demonstrates a wide range of structures, including…

Fluid Dynamics · Physics 2021-12-15 David Schmidt , Romit Maulik , Konstantinos G. Lyras

Robotic manipulation in high-precision tasks is essential for numerous industrial and real-world applications where accuracy and speed are required. Yet current diffusion-based policy learning methods generally suffer from low computational…

Robotics · Computer Science 2025-06-23 Sen Wang , Le Wang , Sanping Zhou , Jingyi Tian , Jiayi Li , Haowen Sun , Wei Tang

Generative models such as diffusion models, excel at capturing high-dimensional distributions with diverse input modalities, e.g. robot trajectories, but are less effective at multi-step constraint reasoning. Task and Motion Planning (TAMP)…

The computational cost associated with simulating fluid flows can make it infeasible to run many simulations across multiple flow conditions. Building upon concepts from generative modeling, we introduce a new method for learning neural…

Computational Physics · Physics 2019-12-17 Jeremy Morton , Freddie D. Witherden , Mykel J. Kochenderfer

Molecular dynamics (MD) simulation is essential for various scientific domains but computationally expensive. Learning-based force fields have made significant progress in accelerating ab-initio MD simulation but are not fast enough for…

Machine Learning · Computer Science 2023-08-29 Xiang Fu , Tian Xie , Nathan J. Rebello , Bradley D. Olsen , Tommi Jaakkola

An implicit multiscale method with multiple macroscopic prediction for steady state solutions of gas flow in all flow regimes is presented. The method is based on the finite volume discrete velocity method (DVM) framework. At the cell…

Computational Physics · Physics 2020-02-19 Ruifeng Yuan , Chengwen Zhong

The volume of fluid (VoF) method is widely used in multi-phase flow simulations to track and locate the interface between two immiscible fluids. A major bottleneck of the VoF method is the interface reconstruction step due to its high…