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Liquid-liquid phase separation is important across biology, physics, and materials science. Although usually studied at equilibrium, active components - such as motor proteins, enzymes, and synthetic microswimmers - are increasingly…

Soft Condensed Matter · Physics 2026-01-06 Kan Chang , Yulin Li , Ming Yuan , Masaki Sano , Zhihong You , H. P. Zhang

Biomolecules, such as proteins and RNAs, can phase separate in the cytoplasm of cells to form biomolecular condensates. Such condensates are liquid-like droplets that can wet biological surfaces such as membranes. Many molecules that…

Soft Condensed Matter · Physics 2024-09-04 Xueping Zhao , Susanne Liese , Alf Honigmann , Frank Jülicher , Christoph A. Weber

Drops in contact with swollen, elastomeric substrates can induce a capillary-mediated phase separation in wetting ridges. Using laser scanning confocal microscopy, we visualize phase separation of oligomeric silicone oil from a crosslinked…

Soft Condensed Matter · Physics 2023-02-06 Lukas Hauer , Zhuoyun Cai , Doris Vollmer , Jonathan T. Pham

Living and engineered systems rely on the stable coexistence of two interspersed liquid phases. Yet surface tension drives their complete separation. Here we show that stable droplets of uniform and tuneable size can be produced through…

Liquid-liquid phase separation has emerged as a fundamental mechanism underlying intracellular organization, with evidence for it being reported in numerous different systems. However, there is a growing concern regarding the lack of…

Soft Condensed Matter · Physics 2022-12-09 Mrityunjay Kothari , Tal Cohen

We propose a continuum theory of the liquid-liquid phase separation in an elastic network where phase-separated microscopic droplets rich in one fluid component can form as an interplay of fluids mixing, droplet nucleation, network…

Soft Condensed Matter · Physics 2021-01-04 Xuefeng Wei , Jiajia Zhou , Yanting Wang , Fanlong Meng

A recent study has demonstrated that phase separation in binary liquid mixtures is arrested in the presence of elastic networks and can lead to a nearly uniformly-sized distribution of the dilute-phase droplets. At longer timescales, these…

Soft Condensed Matter · Physics 2020-10-28 Mrityunjay Kothari , Tal Cohen

Liquid drops start spreading directly after brought into contact with a partial wetting substrate. Although this phenomenon involves a three-phase contact line, the spreading motion is very fast. We study the initial spreading dynamics of…

Fluid Dynamics · Physics 2012-11-19 Koen G. Winkels , Joost H. Weijs , Antonin Eddi , Jacco H. Snoeijer

Liquid-liquid phase separation of aqueous two-phase system (ATPS) is fundamental across physical and biological sciences. While well understood for passive systems, how this process is regulated by active agents such as motile bacteria…

Soft Condensed Matter · Physics 2025-11-25 Dixi Yang , Anheng Wang , Chunming Wang , Hajime Tanaka , Jiaxing Yuan

Recent experimental realizations of liquid-liquid phase separation of active liquid crystals have offered an insight into the interaction between phase separation, ubiquitous in soft matter and biology, and chaotic active flows. In this…

Soft Condensed Matter · Physics 2025-04-23 Paarth Gulati , Fernando Caballero , M. Cristina Marchetti

Hypothesis: Surrounding fluids affect critically drop wetting dynamics in many applications involving viscous environments. Although macroscopic effects of outer fluid viscosity on contact line motion have been documented, the extent to…

Fluid Dynamics · Physics 2025-12-15 Yingjie Fei , Qindan Zhang , Youguang Ma , Huai-Zhi Li

Moving contact lines of more than two phases dictate a large number of interfacial phenomena. Despite its significance to fundamental and applied processes, the contact lines at a junction of four-phases (two immiscible liquids, solid and…

Soft Condensed Matter · Physics 2020-06-14 Haitao Yu , Pallav Kant , Brendan Dyett , Detlef Lohse , Xuehua Zhang

Liquid droplets on soft solids, such as soft polymeric gels, can induce substantial surface deformations, leading to the formation of wetting ridges at contact points. While these contact ridges have been shown to govern the rich surface…

Soft Condensed Matter · Physics 2024-08-27 Wenjie Qian , Weiwei Zhao , Tiezheng Qian , Qin Xu

Liquid-liquid phase separation is key to understanding aqueous two-phase systems (ATPS) arising throughout cell biology, medical science, and the pharmaceutical industry. Controlling the detailed morphology of phase-separating compound…

Soft Condensed Matter · Physics 2023-10-27 Eric W. Hester , Sean P. Carney , Vishwesh Shah , Alyssa Arnheim , Bena Patel , Dino Di Carlo , Andrea L. Bertozzi

We extend the continuum theories of active nematohydrodynamics to model a two-fluid mixture with separate velocity fields for each fluid component, coupled through a viscous drag. The model is used to study an active nematic fluid, mixed…

Soft Condensed Matter · Physics 2023-08-02 Saraswat Bhattacharyya , Julia M. Yeomans

Phase separation drives the formation of biomolecular condensates in cells, which comprise many components and sometimes possess multiple phases. The equilibrium physics of phase separation is well understood, but many components in…

Soft Condensed Matter · Physics 2025-08-14 Yicheng Qiang , Chengjie Luo , David Zwicker

Controlling the spatial distribution of liquid droplets on surfaces via surface energy patterning can be used to control material delivery to specified regions via selective liquid/solid wetting. While studies of the equilibrium shape of…

Soft Condensed Matter · Physics 2007-05-23 Gary S. Grest , David R. Heine , Edmund B. Webb

The rapid adhesion of motile bacteria from dilute suspensions poses a fundamental non-equilibrium problem: hydrodynamic interactions bias bacterial motion near surfaces without generating stable confinement, while electrostatic interactions…

Soft Condensed Matter · Physics 2026-01-13 Dixi Yang , Anheng Wang , Jia Huang , Xiaofeng Zhuo , Chunming Wang , Hajime Tanaka , Jiaxing Yuan

The understanding of the spreading of liquids on solid surfaces is an important challenge for contemporary physics. Today, the motion of the contact line formed at the intersection of two immiscible fluids and a solid is still subject to…

Classical Physics · Physics 2009-11-13 Henri Gouin

Various biological and chemical processes lead to the nucleation and growth of non-wetting fluid bubbles within the pore space of a granular medium, such as the formation of gas bubbles in liquid-saturated lake-bed sediments. In…

Soft Condensed Matter · Physics 2022-05-13 Oliver W. Paulin , Liam C. Morrow , Matthew G. Hennessy , Christopher W. MacMinn
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