Related papers: Commentary: analyzing binary data using MCPMod whe…
This paper proposes a new generalized linear model with the fractional binomial distribution. Zero-inflated Poisson/negative binomial distributions are used for count data with many zeros. To analyze the association of such a count variable…
In survival analysis, estimating the fraction of 'immune' or 'cured' subjects who will never experience the event of interest, requires a sufficiently long follow-up period. A few statistical tests have been proposed to test the assumption…
Given the prominence of targeted therapy and immunotherapy in cancer treatment, it becomes imperative to consider heterogeneity in patients' responses to treatments, which contributes greatly to the widely used proportional hazard…
Clustered observations are ubiquitous in controlled and observational studies and arise naturally in multi-centre trials or longitudinal surveys. We present a novel model for the analysis of clustered observations where the marginal…
We propose a new approach for sparse regression and marginal testing, for data with correlated features. Our procedure first clusters the features, and then chooses as the cluster prototype the most informative feature in that cluster. Then…
The recently introduced backward Monte-Carlo method [Johan Carlsson, arXiv:math.NA/0010118] is validated, benchmarked, and compared to the conventional, forward Monte-Carlo method by analyzing the error in the Monte-Carlo solutions to a…
When different researchers study the same research question using the same dataset they may obtain different and potentially even conflicting results. This is because there is often substantial flexibility in researchers' analytical…
Given only positive examples and unlabeled examples (from both positive and negative classes), we might hope nevertheless to estimate an accurate positive-versus-negative classifier. Formally, this task is broken down into two subtasks: (i)…
We propose a frequentist adaptive phase 2 trial design to evaluate the safety and efficacy of three treatment regimens (doses) compared to placebo for four types of helminth (worm) infections. This trial will be carried out in four…
It is common to address the curse of dimensionality in Markov decision processes (MDPs) by exploiting low-rank representations. This motivates much of the recent theoretical study on linear MDPs. However, most approaches require a given…
The high precision and conformity of intensity-modulated particle therapy (IMPT) comes at the cost of susceptibility to treatment uncertainties in particle range and patient set-up. Dose uncertainty quantification and mitigation, which is…
Approximate Bayesian Computational (ABC) methods (or likelihood-free methods) have appeared in the past fifteen years as useful methods to perform Bayesian analyses when the likelihood is analytically or computationally intractable. Several…
This paper describes a compound Poisson-based random effects structure for modeling zero-inflated data. Data with large proportion of zeros are found in many fields of applied statistics, for example in ecology when trying to model and…
We propose a data-driven method to learn the time-dependent probability density of a multivariate stochastic process from sample paths, assuming that the initial probability density is known and can be evaluated. Our method uses a novel…
The robust rank-order test (Fligner and Policello, 1981) was designed as an improvement of the non-parametric Wilcoxon-Mann-Whitney U-test to be more appropriate when the samples being compared have unequal variance. However, it tends to be…
Contrastive learning has shown remarkable results in recent self-supervised approaches for visual representation. By learning to contrast positive pairs' representation from the corresponding negatives pairs, one can train good visual…
In this paper, we consider the bipolar approach to Multiple Criteria Decision Analysis (MCDA). In particular we aggregate positive and negative preferences by means of the bipolar PROMETHEE method. To elicit preferences we consider Robust…
Biopharmaceutical products, particularly monoclonal antibodies (mAbs), have gained prominence in the pharmaceutical market due to their high specificity and efficacy. As these products are projected to constitute a substantial portion of…
To analyze longitudinal zero-inflated count data, we extend existing models by introducing marginalized zero-inflated Poisson (MZIP) models with random effects, which explicitly capture the marginal effect of covariates and address…
In recent years there has been an increase in the number of scientific papers that suggest using conformal predictions in drug discovery. We consider that some versions of conformal predictions applied in binary settings are embroiled in…