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Instrumental variable methods are widely used for inferring the causal effect in the presence of unmeasured confounders. Existing instrumental variable methods for nonlinear outcome models require stringent identifiability conditions. This…

Methodology · Statistics 2022-07-01 Sai Li , Zijian Guo

With the rapid advancement of deep learning and related technologies, Autonomous Driving Systems (ADSs) have made significant progress and are gradually being widely applied in safety-critical fields. However, numerous accident reports show…

Software Engineering · Computer Science 2025-09-03 Pin Ji , Yang Feng , Zongtai Li , Xiangchi Zhou , Jia Liu , Jun Sun , Zhihong Zhao

The safety and reliability of Automated Driving Systems (ADS) are paramount, necessitating rigorous testing methodologies to uncover potential failures before deployment. Traditional testing approaches often prioritize either natural…

This study introduces a data-driven, machine learning-based method to detect suitable control variables and instruments for assessing the causal effect of a treatment on an outcome in observational data. Our approach tests the joint…

Econometrics · Economics 2026-05-20 Nicolas Apfel , Julia Hatamyar , Martin Huber , Jannis Kueck

Estimating conditional average dose responses (CADR) is an important but challenging problem. Estimators must correctly model the potentially complex relationships between covariates, interventions, doses, and outcomes. In recent years, the…

Machine Learning · Computer Science 2024-06-13 Christopher Bockel-Rickermann , Toon Vanderschueren , Tim Verdonck , Wouter Verbeke

Coronary artery disease remains one of the leading causes of mortality globally. Despite advances in revascularization treatments like PCI and CABG, postoperative stroke is inevitable. This study aims to develop and evaluate a sophisticated…

Machine Learning · Computer Science 2025-03-18 Haonan Pan , Shuheng Chen , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Automated organ at risk (OAR) segmentation is crucial for radiation therapy planning in CT scans, but the generated contours by automated models can be inaccurate, potentially leading to treatment planning issues. The reasons for these…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Amin Honarmandi Shandiz , Attila Rádics , Rajesh Tamada , Makk Árpád , Karolina Glowacka , Lehel Ferenczi , Sandeep Dutta , Michael Fanariotis

Binary classification involves predicting the label of an instance based on whether the model score for the positive class exceeds a threshold chosen based on the application requirements (e.g., maximizing recall for a precision bound).…

Machine Learning · Computer Science 2023-11-21 Gundeep Arora , Srujana Merugu , Anoop Saladi , Rajeev Rastogi

Conformal prediction (CP) quantifies the uncertainty of machine learning models by constructing sets of plausible outputs. These sets are constructed by leveraging a so-called conformity score, a quantity computed using the input point of…

Machine Learning · Statistics 2025-02-07 Michal Klein , Louis Bethune , Eugene Ndiaye , Marco Cuturi

Checklists are simple decision aids that are often used to promote safety and reliability in clinical applications. In this paper, we present a method to learn checklists for clinical decision support. We represent predictive checklists as…

Machine Learning · Computer Science 2022-01-19 Haoran Zhang , Quaid Morris , Berk Ustun , Marzyeh Ghassemi

Score-based causal discovery methods can effectively identify causal relationships by evaluating candidate graphs and selecting the one with the highest score. One popular class of scores is kernel-based generalized score functions, which…

Machine Learning · Computer Science 2025-06-10 Yixin Ren , Haocheng Zhang , Yewei Xia , Hao Zhang , Jihong Guan , Shuigeng Zhou

Anomaly detection plays a crucial role in various real-world applications, including healthcare and finance systems. Owing to the limited number of anomaly labels in these complex systems, unsupervised anomaly detection methods have…

Machine Learning · Computer Science 2023-10-10 Zongyuan Huang , Baohua Zhang , Guoqiang Hu , Longyuan Li , Yanyan Xu , Yaohui Jin

Automated machine learning (AutoML) systems aim to enable training machine learning (ML) models for non-ML experts. A shortcoming of these systems is that when they fail to produce a model with high accuracy, the user has no path to improve…

Machine Learning · Computer Science 2021-02-23 Behnaz Arzani , Kevin Hsieh , Haoxian Chen

Machine learning classification tasks often benefit from predicting a set of possible labels with confidence scores to capture uncertainty. However, existing methods struggle with the high-dimensional nature of the data and the lack of…

Machine Learning · Computer Science 2024-07-08 Rui Luo , Zhixin Zhou

The SYNTAX score has become a widely used measure of coronary disease severity, crucial in selecting the optimal mode of the revascularization procedure. This paper introduces a new medical regression and classification problem -…

Computer Vision and Pattern Recognition · Computer Science 2025-05-07 Alexander Ponomarchuk , Ivan Kruzhilov , Galina Zubkova , Artem Shadrin , Ruslan Utegenov , Ivan Bessonov , Pavel Blinov

Despite recent progress in predicting biomarker trajectories from real clinical data, uncertainty in the predictions poses high-stakes risks (e.g., misdiagnosis) that limit their clinical deployment. To enable safe and reliable use of such…

Machine Learning · Statistics 2025-11-19 Vasiliki Tassopoulou , Charis Stamouli , Haochang Shou , George J. Pappas , Christos Davatzikos

The impact of machine learning models on healthcare will depend on the degree of trust that healthcare professionals place in the predictions made by these models. In this paper, we present a method to provide people with clinical expertise…

Machine Learning · Computer Science 2021-03-05 Aniruddh Raghu , John Guttag , Katherine Young , Eugene Pomerantsev , Adrian V. Dalca , Collin M. Stultz

Stroke is a major public health problem, affecting millions worldwide. Deep learning has recently demonstrated promise for enhancing the diagnosis and risk prediction of stroke. However, existing methods rely on costly medical imaging…

Image and Video Processing · Electrical Eng. & Systems 2025-12-17 Saeed Shurrab , Aadim Nepal , Terrence J. Lee-St. John , Nicola G. Ghazi , Bartlomiej Piechowski-Jozwiak , Farah E. Shamout

Heterogeneous treatment effect (HTE) estimation is critical in medical research. It provides insights into how treatment effects vary among individuals, which can provide statistical evidence for precision medicine. While most existing…

Machine Learning · Statistics 2025-04-25 Ke Wan , Kensuke Tanioka , Toshio Shimokawa

Estimation of individual treatment effects is commonly used as the basis for contextual decision making in fields such as healthcare, education, and economics. However, it is often sufficient for the decision maker to have estimates of…

Machine Learning · Computer Science 2020-08-13 Maggie Makar , Fredrik D. Johansson , John Guttag , David Sontag
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