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Retrosynthesis prediction is one of the fundamental challenges in organic synthesis. The task is to predict the reactants given a core product. With the advancement of machine learning, computer-aided synthesis planning has gained…

Chemical Physics · Physics 2022-02-01 Yue Wan , Benben Liao , Chang-Yu Hsieh , Shengyu Zhang

In this paper we introduce SemiGPC, a distribution-aware label refinement strategy based on Gaussian Processes where the predictions of the model are derived from the labels posterior distribution. Differently from other buffer-based…

Computer Vision and Pattern Recognition · Computer Science 2023-11-06 Abdelhak Lemkhenter , Manchen Wang , Luca Zancato , Gurumurthy Swaminathan , Paolo Favaro , Davide Modolo

Single-step retrosynthesis aims to predict a set of reactions that lead to the creation of a target molecule, which is a crucial task in molecular discovery. Although a target molecule can often be synthesized with multiple different…

Machine Learning · Computer Science 2025-04-15 Piotr Gaiński , Michał Koziarski , Krzysztof Maziarz , Marwin Segler , Jacek Tabor , Marek Śmieja

We present a semi-supervised fine-tuning framework for foundation models that utilises mutual information decomposition to address the challenges of training for a limited amount of labelled data. Our approach derives two distinct lower…

Machine Learning · Computer Science 2025-05-19 Guillaume Quétant , Pavlo Molchanov , Slava Voloshynovskiy

Retrosynthesis consists of breaking down a chemical compound recursively step-by-step into molecular precursors until a set of commercially available molecules is found with the goal to provide a synthesis route. Its two primary research…

Artificial Intelligence · Computer Science 2024-03-12 Paula Torren-Peraire , Alan Kai Hassen , Samuel Genheden , Jonas Verhoeven , Djork-Arne Clevert , Mike Preuss , Igor Tetko

Table detection, a pivotal task in document analysis, aims to precisely recognize and locate tables within document images. Although deep learning has shown remarkable progress in this realm, it typically requires an extensive dataset of…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Iqraa Ehsan , Tahira Shehzadi , Didier Stricker , Muhammad Zeshan Afzal

In this paper, a new method of training pipeline is discussed to achieve significant performance on the task of anti-spoofing with RGB image. We explore and highlight the impact of using pseudo-depth to pre-train a network that will be used…

Computer Vision and Pattern Recognition · Computer Science 2021-03-22 Chang Keun Paik , Naeun Ko , Youngjoon Yoo

Retrosynthesis analysis is pivotal yet challenging in drug discovery and organic chemistry. Despite the proliferation of computational tools over the past decade, AI-based systems often fall short in generalizing across diverse reaction…

Machine Learning · Computer Science 2024-08-21 Yifei Yang , Runhan Shi , Zuchao Li , Shu Jiang , Bao-Liang Lu , Yang Yang , Hai Zhao

In this paper, we provide a series of multi-tasking benchmarks for simultaneously detecting spoofing at the segmental and utterance levels in the PartialSpoof database. First, we propose the SELCNN network, which inserts…

Sound · Computer Science 2021-09-01 Lin Zhang , Xin Wang , Erica Cooper , Junichi Yamagishi

We evaluate the effectiveness of semi-supervised learning (SSL) on a realistic benchmark where data exhibits considerable class imbalance and contains images from novel classes. Our benchmark consists of two fine-grained classification…

Computer Vision and Pattern Recognition · Computer Science 2021-04-02 Jong-Chyi Su , Zezhou Cheng , Subhransu Maji

Recent trends in lower precision, e.g. half-precision floating point, training have shown improved system performance and reduced memory usage for Deep Learning while maintaining accuracy. However, current GNN systems cannot achieve such…

Machine Learning · Computer Science 2025-09-17 Arnab Kanti Tarafder , Yidong Gong , Pradeep Kumar

We introduce Model Feedback Learning (MFL), a novel test-time optimization framework for optimizing inputs to pre-trained AI models or deployed hardware systems without requiring any retraining of the models or modifications to the…

Machine Learning · Computer Science 2025-05-23 Shangding Gu , Donghao Ying , Ming Jin , Yu Joe Lu , Jun Wang , Javad Lavaei , Costas Spanos

Tensor completion estimates missing components by exploiting the low-rank structure of multi-way data. The recently proposed methods based on tensor train (TT) and tensor ring (TR) show better performance in image recovery than classical…

Machine Learning · Computer Science 2020-04-24 Huyan Huang , Yipeng Liu , Ce Zhu

Modern deep learning models in computer vision require large datasets of real images, which are difficult to curate and pose privacy and legal concerns, limiting their commercial use. Recent works suggest synthetic data as an alternative,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Farnood Salehi , Vandit Sharma , Amirhossein Askari Farsangi , Tunç Ozan Aydın

Retrosynthesis is essential for designing synthetic pathways for complex molecules and can be revolutionized by AI to automate and accelerate chemical synthesis planning for drug discovery and materials science. Here, we propose a…

Chemical Physics · Physics 2024-12-02 Seongeun Yun , Won Bo Lee

Semi-supervised learning frameworks usually adopt mutual learning approaches with multiple submodels to learn from different perspectives. To avoid transferring erroneous pseudo labels between these submodels, a high threshold is usually…

Computer Vision and Pattern Recognition · Computer Science 2023-01-11 Hao Xu , Hui Xiao , Huazheng Hao , Li Dong , Xiaojie Qiu , Chengbin Peng

Photorealistic color retouching plays a vital role in visual content creation, yet manual retouching remains inaccessible to non-experts due to its reliance on specialized expertise. Reference-based methods offer a promising alternative by…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Melany Yang , Yuhang Yu , Diwang Weng , Jinwei Chen , Wei Dong

Retrosynthesis prediction is fundamental to drug discovery and chemical synthesis, requiring the identification of reactants that can produce a target molecule. Current template-free methods struggle to capture the structural invariance…

Machine Learning · Computer Science 2025-10-21 Jiaxi Zhuang , Yu Zhang , Aimin Zhou , Ying Qian

Template-based molecular generation offers a promising avenue for drug design by ensuring generated compounds are synthetically accessible through predefined reaction templates and building blocks. In this work, we tackle three core…

Retrosynthesis is the task of planning a series of chemical reactions to create a desired molecule from simpler, buyable molecules. While previous works have proposed algorithms to find optimal solutions for a range of metrics (e.g.…

Artificial Intelligence · Computer Science 2024-04-16 Austin Tripp , Krzysztof Maziarz , Sarah Lewis , Marwin Segler , José Miguel Hernández-Lobato