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Because of the high cost of commercial genotyping chip technologies, many investigations have used a two-stage design for genome-wide association studies, using part of the sample for an initial discovery of ``promising'' SNPs at a less…

Gene expression programming is an evolutionary optimization algorithm with the potential to generate interpretable and easily implementable equations for regression problems. Despite knowledge gained from previous optimizations being…

Neural and Evolutionary Computing · Computer Science 2025-02-05 Maximilian Reissmann , Yuan Fang , Andrew S. H. Ooi , Richard D. Sandberg

Evolutionary computing, particularly genetic algorithm (GA), is a combinatorial optimization method inspired by natural selection and the transmission of genetic information, which is widely used to identify optimal solutions to complex…

Neural and Evolutionary Computing · Computer Science 2024-12-31 Shanqing Yu , Meng Zhou , Jintao Zhou , Minghao Zhao , Yidan Song , Yao Lu , Zeyu Wang , Qi Xuan

Representations for black-box optimisation methods (such as evolutionary algorithms) are traditionally constructed using a delicate manual process. This is in contrast to the representation that maps DNAs to phenotypes in biological…

Neural and Evolutionary Computing · Computer Science 2024-07-08 Milton L. Montero , Erwan Plantec , Eleni Nisioti , Joachim W. Pedersen , Sebastian Risi

Non-dominated sorting genetic algorithm II (NSGA-II) does well in dealing with multi-objective problems. When evaluating validity of an algorithm for multi-objective problems, two kinds of indices are often considered simultaneously, i.e.…

Neural and Evolutionary Computing · Computer Science 2018-12-03 Xiangxiang Chu , Xinjie Yu

Symbolic regression is an important but challenging research topic in data mining. It can detect the underlying mathematical models. Genetic programming (GP) is one of the most popular methods for symbolic regression. However, its…

Data Structures and Algorithms · Computer Science 2017-05-16 Chen Chen , Changtong Luo , Zonglin Jiang

Adapting large language models (LLMs) to a targeted task efficiently and effectively remains a fundamental challenge. Such adaptation often requires iteratively improving the model toward a targeted task, yet collecting high-quality…

Computation and Language · Computer Science 2026-04-30 Ting-Wei Li , Sirui Chen , Jiaru Zou , Yingbing Huang , Tianxin Wei , Jingrui He , Hanghang Tong

Software model optimization is the task of automatically generate design alternatives, usually to improve quality aspects of software that are quantifiable, like performance and reliability. In this context, multi-objective optimization…

Software Engineering · Computer Science 2024-01-31 Daniele Di Pompeo , Michele Tucci

Second-generation sequencing technologies have replaced array-based technologies and become the default method for genomics and epigenomics analysis. Second-generation sequencing technologies sequence tens of millions of DNA/cDNA fragments…

Methodology · Statistics 2017-02-08 Ping Ma , Nan Zhang , Jianhua Z. Huang , Wenxuan Zhong

Isotonic regression is a nonparametric approach for fitting monotonic models to data that has been widely studied from both theoretical and practical perspectives. However, this approach encounters computational and statistical overfitting…

Methodology · Statistics 2012-03-21 Ronny Luss , Saharon Rosset , Moni Shahar

In modern multi-stage recommendation systems, reranking plays a critical role by modeling contextual information. Due to inherent challenges such as the combinatorial space complexity, an increasing number of methods adopt the generative…

Information Retrieval · Computer Science 2026-04-08 Shuli Wang , Changhao Li , Ke Fan , Senjie Kou Junwei Yin , Chi Wang , Yinhua Zhu , Haitao Wang , Xingxing Wang

Interpretable regression models are important for many application domains, as they allow experts to understand relations between variables from sparse data. Symbolic regression addresses this issue by searching the space of all possible…

Artificial Intelligence · Computer Science 2022-06-14 Marcus Märtens , Dario Izzo

Decompilation aims to recover the source code form of a binary executable. It has many security applications, such as malware analysis, vulnerability detection, and code hardening. A prominent challenge in decompilation is to recover…

Software Engineering · Computer Science 2024-12-10 Xiangzhe Xu , Zhuo Zhang , Zian Su , Ziyang Huang , Shiwei Feng , Yapeng Ye , Nan Jiang , Danning Xie , Siyuan Cheng , Lin Tan , Xiangyu Zhang

Deep generative models provide powerful tools for distributions over complicated manifolds, such as those of natural images. But many of these methods, including generative adversarial networks (GANs), can be difficult to train, in part…

Machine Learning · Statistics 2017-11-08 Akash Srivastava , Lazar Valkov , Chris Russell , Michael U. Gutmann , Charles Sutton

Test-time algorithms that combine the generative power of language models with process verifiers that assess the quality of partial generations offer a promising lever for eliciting new reasoning capabilities, but the algorithmic design…

Machine Learning · Computer Science 2025-10-06 Dhruv Rohatgi , Abhishek Shetty , Donya Saless , Yuchen Li , Ankur Moitra , Andrej Risteski , Dylan J. Foster

Mathematical expressions play a central role in scientific discovery. Symbolic regression aims to automatically discover such expressions from given numerical data. Recently, Neural symbolic regression (NSR) methods that involve…

Machine Learning · Computer Science 2026-02-03 Shun Sato , Issei Sato

Classification in the dissimilarity space has become a very active research area since it provides a possibility to learn from data given in the form of pairwise non-metric dissimilarities, which otherwise would be difficult to cope with.…

Symbolic regression is emerging as a promising machine learning method for learning succinct underlying interpretable mathematical expressions directly from data. Whereas it has been traditionally tackled with genetic programming, it has…

Machine Learning · Computer Science 2025-01-14 Nour Makke , Sanjay Chawla

Deep generative models (DGMs) are data-eager because learning a complex model on limited data suffers from a large variance and easily overfits. Inspired by the classical perspective of the bias-variance tradeoff, we propose regularized…

Machine Learning · Computer Science 2023-04-11 Yong Zhong , Hongtao Liu , Xiaodong Liu , Fan Bao , Weiran Shen , Chongxuan Li

Many statistical problems involve optimization over a discrete parameter space having an unknown dimension. In such settings, gradient-based methods often fail due to the non-differentiability of the objective function or a non-convex or…

Applications · Statistics 2026-03-19 Mo Li , QiQi Lu , Robert Lund , Xueheng Shi
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