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Retrosynthesis is one of the fundamental problems in organic chemistry. The task is to identify reactants that can be used to synthesize a specified product molecule. Recently, computer-aided retrosynthesis is finding renewed interest from…

Machine Learning · Computer Science 2020-01-07 Hanjun Dai , Chengtao Li , Connor W. Coley , Bo Dai , Le Song

Generative molecular optimization aims to design molecules with properties surpassing those of existing compounds. However, such candidates are rare and expensive to evaluate, yielding sample efficiency essential. Additionally, surrogate…

Despite the somewhat different techniques used in developing search engines and recommender systems, they both follow the same goal: helping people to get the information they need at the right time. Due to this common goal, search and…

Information Retrieval · Computer Science 2018-07-17 Hamed Zamani , W. Bruce Croft

Most of the existing medication recommendation models are predicted with only structured data such as medical codes, with the remaining other large amount of unstructured or semi-structured data underutilization. To increase the utilization…

Computation and Language · Computer Science 2024-07-16 Yu-Tzu Lee

Recommender systems serve as foundational infrastructure in modern information ecosystems, helping users navigate digital content and discover items aligned with their preferences. At their core, recommender systems address a fundamental…

Information Retrieval · Computer Science 2026-05-12 Min Hou , Le Wu , Yuxin Liao , Yonghui Yang , Zhen Zhang , Yu Wang , Changlong Zheng , Han Wu , Richang Hong

Generating novel molecules is challenging, with most representations leading to generative models producing many invalid molecules. Spanning Tree-based Graph Generation (STGG) is a promising approach to ensure the generation of valid…

Machine Learning · Computer Science 2025-07-17 Alexia Jolicoeur-Martineau , Aristide Baratin , Kisoo Kwon , Boris Knyazev , Yan Zhang

We present a collection recommender system that can automatically create and recommend collections of items at a user level. Unlike regular recommender systems, which output top-N relevant items, a collection recommender system outputs…

Information Retrieval · Computer Science 2021-05-04 Sanidhya Singal , Piyush Singh , Manjeet Dahiya

Medical research is risky and expensive. Drug discovery, as an example, requires that researchers efficiently winnow thousands of potential targets to a small candidate set for more thorough evaluation. However, research groups spend…

Machine Learning · Computer Science 2020-02-14 Justin Sybrandt , Ilya Tyagin , Michael Shtutman , Ilya Safro

Knowledge graph (KG) enhanced recommendation has demonstrated improved performance in the recommendation system (RecSys) and attracted considerable research interest. Recently the literature has adopted neural graph networks (GNNs) on the…

Information Retrieval · Computer Science 2022-11-15 Liangwei Yang , Shen Wang , Jibing Gong , Shaojie Zheng , Shuying Du , Zhiwei Liu , Philip S. Yu

Diagnosing cognitive (mental health) disorders is a delicate and complex task. Identifying the next most informative symptoms to assess, in order to distinguish between possible disorders, presents an additional challenge. This process…

Information Retrieval · Computer Science 2025-11-25 Raoul H. Kutil , Georg Zimmermann , Christian Borgelt

Reranking models solve the final recommendation lists that best fulfill users' demands. While existing solutions focus on finding parametric models that approximate optimal policies, recent approaches find that it is better to generate…

Information Retrieval · Computer Science 2025-04-23 Hailan Yang , Zhenyu Qi , Shuchang Liu , Xiaoyu Yang , Xiaobei Wang , Xiang Li , Lantao Hu , Han Li , Kun Gai

Most existing medication recommendation models learn representations for medical concepts based on electronic health records (EHRs) and make recommendations with learnt representations. However, most medications appear in the dataset for…

Machine Learning · Computer Science 2024-02-16 Weicong Tan , Weiqing Wang , Xin Zhou , Wray Buntine , Gordon Bingham , Hongzhi Yin

Generative Recommendation (GR) has emerged as a new paradigm in recommender systems. This approach relies on quantized representations to discretize item features, modeling users' historical interactions as sequences of discrete tokens.…

Information Retrieval · Computer Science 2025-11-25 Fuwei Zhang , Xiaoyu Liu , Dongbo Xi , Jishen Yin , Huan Chen , Peng Yan , Fuzhen Zhuang , Zhao Zhang

We propose a deep generative approach to sampling from a conditional distribution based on a unified formulation of conditional distribution and generalized nonparametric regression function using the noise-outsourcing lemma. The proposed…

Statistics Theory · Mathematics 2021-10-22 Xingyu Zhou , Yuling Jiao , Jin Liu , Jian Huang

The recent advances in Large Language Model's generation and reasoning capabilities present an opportunity to develop truly conversational recommendation systems. However, effectively integrating recommender system knowledge into LLMs for…

Computation and Language · Computer Science 2024-12-11 Krishna Sayana , Raghavendra Vasudeva , Yuri Vasilevski , Kun Su , Liam Hebert , James Pine , Hubert Pham , Ambarish Jash , Sukhdeep Sodhi

Conversational recommender systems have attracted immense attention recently. The most recent approaches rely on neural models trained on recorded dialogs between humans, implementing an end-to-end learning process. These systems are…

Information Retrieval · Computer Science 2022-05-26 Ahtsham Manzoor , Dietmar Jannach

Background: The problem of predicting whether a drug combination of arbitrary orders is likely to induce adverse drug reactions is considered in this manuscript. Methods: Novel kernels over drug combinations of arbitrary orders are…

Machine Learning · Computer Science 2019-02-26 Wen-Hao Chiang , Li Shen , Lang Li , Xia Ning

Operational decisions in healthcare, logistics, and public policy increasingly involve algorithms that recommend candidate solutions, such as treatment plans, delivery routes, or policy options, while leaving the final choice to human…

Machine Learning · Computer Science 2025-08-06 Michael Lingzhi Li , Shixiang Zhu

Biomedical research papers use significantly different language and jargon when compared to typical English text, which reduces the utility of pre-trained NLP models in this domain. Meanwhile Medline, a database of biomedical abstracts,…

Machine Learning · Computer Science 2021-09-15 Justin Sybrandt , Ilya Safro

It is well known that Drug Design is often a costly process both in terms of time and economic effort. While good Quantitative Structure-Activity Relationship models (QSAR) can help predicting molecular properties without the need to…

Biomolecules · Quantitative Biology 2022-02-14 Dylan Savoia , Alessio Ragno , Roberto Capobianco