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Precis: A hybrid deep-learning model combines NFL reflectance and other OCT parameters to improve glaucoma diagnosis. Objective: To investigate if a deep learning model could be used to combine nerve fiber layer (NFL) reflectance and other…

Image and Video Processing · Electrical Eng. & Systems 2024-06-07 Ou Tan , David S. Greenfield , Brian A. Francis , Rohit Varma , Joel S. Schuman , David Huang , Dongseok Choi

Glaucoma, a leading cause of irreversible blindness, necessitates early detection for accurate and timely intervention to prevent irreversible vision loss. In this study, we present a novel deep learning framework that leverages the…

Image and Video Processing · Electrical Eng. & Systems 2025-09-05 Mona Ashtari-Majlan , David Masip

Observing retinal fundus images by an ophthalmologist is a major diagnosis approach for glaucoma. However, it is still difficult to distinguish the features of the lesion solely through manual observations, especially, in glaucoma early…

Image and Video Processing · Electrical Eng. & Systems 2020-01-08 Peng Liu , Ruogu Fang

Purpose: To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods: A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1…

Color fundus photography and Optical Coherence Tomography (OCT) are the two most cost-effective tools for glaucoma screening. Both two modalities of images have prominent biomarkers to indicate glaucoma suspected. Clinically, it is often…

In this manuscript, we present a robust method for glaucoma screening from fundus images using an ensemble of convolutional neural networks (CNNs). The pipeline comprises of first segmenting the optic disk and optic cup from the fundus…

Computer Vision and Pattern Recognition · Computer Science 2018-09-17 Vismay Agrawal , Avinash Kori , Varghese Alex , Ganapathy Krishnamurthi

Despite significant advancements, segmentation based on deep neural networks in medical and surgical imaging faces several challenges, two of which we aim to address in this work. First, acquiring complete pixel-level segmentation labels…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Junwen Wang , Zhonghao Wang , Oscar MacCormac , Jonathan Shapey , Tom Vercauteren

Annotation variability remains a substantial challenge in medical image segmentation, stemming from ambiguous imaging boundaries and diverse clinical expertise. Traditional deep learning methods producing single deterministic segmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Han Zhang , Xiangde Luo , Yong Chen , Kang Li

This study develops meta-learners for few-shot weakly-supervised segmentation (FWS) to address the challenge of optic disc (OD) and optic cup (OC) segmentation for glaucoma diagnosis with limited labeled fundus images. We significantly…

Image and Video Processing · Electrical Eng. & Systems 2025-12-19 Pandega Abyan Zumarsyah , Igi Ardiyanto , Hanung Adi Nugroho

Fundus photography has been routinely used to document the presence and severity of various retinal degenerative diseases such as age-related macula degeneration, glaucoma, and diabetic retinopathy, for which the fovea, optic disc (OD), and…

Image and Video Processing · Electrical Eng. & Systems 2022-03-02 Huaqing He , Li Lin , Zhiyuan Cai , Xiaoying Tang

Previous approaches using deep learning algorithms to classify glaucomatous damage on fundus photographs have been limited by the requirement for human labeling of a reference training set. We propose a new approach using spectral-domain…

Computer Vision and Pattern Recognition · Computer Science 2018-10-25 Felipe A. Medeiros , Alessandro A. Jammal , Atalie C. Thompson

It is feasible to recognize the presence and seriousness of eye disease by investigating the progressions in retinal biological structure. Fundus examination is a diagnostic procedure to examine the biological structure and anomaly of the…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Amit Bhati , Neha Gour , Pritee Khanna , Aparajita Ojha

Purpose: (1) To assess the performance of geometric deep learning (PointNet) in diagnosing glaucoma from a single optical coherence tomography (OCT) 3D scan of the optic nerve head (ONH); (2) To compare its performance to that obtained with…

Image and Video Processing · Electrical Eng. & Systems 2022-04-15 Alexandre H. Thiery , Fabian Braeu , Tin A. Tun , Tin Aung , Michael J. A. Girard

Glaucomatous optic neuropathy (GON) is a prevalent ocular disease that can lead to irreversible vision loss if not detected early and treated. The traditional diagnostic approach for GON involves a set of ophthalmic examinations, which are…

Automated diagnosis based on color fundus photography is essential for large-scale glaucoma screening. However, existing deep learning models are typically data-driven and lack explicit integration of retinal anatomical knowledge, which…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Yuzhuo Zhou , Chi Liu , Sheng Shen , Zongyuan Ge , Fengshi Jing , Shiran Zhang , Yu Jiang , Anli Wang , Wenjian Liu , Feilong Yang , Tianqing Zhu , Xiaotong Han

Deep learning models, such as the fully convolutional network (FCN), have been widely used in 3D biomedical segmentation and achieved state-of-the-art performance. Multiple modalities are often used for disease diagnosis and quantification.…

Image and Video Processing · Electrical Eng. & Systems 2019-08-23 Yu Chen , Jiawei Chen , Dong Wei , Yuexiang Li , Yefeng Zheng

Artificial Intelligence for RObust Glaucoma Screening (AIROGS) Challenge is held for developing solutions for glaucoma screening from color fundus photography that are robust to real-world scenarios. This report describes our method…

Computer Vision and Pattern Recognition · Computer Science 2022-02-25 Satoshi Kondo , Satoshi Kasai , Kosuke Hirasawa

Glaucoma is a serious ocular disorder for which the screening and diagnosis are carried out by the examination of the optic nerve head (ONH). The color fundus image (CFI) is the most common modality used for ocular screening. In CFI, the…

Image and Video Processing · Electrical Eng. & Systems 2019-02-05 Sharath M Shankaranarayana , Keerthi Ram , Kaushik Mitra , Mohanasankar Sivaprakasam

In this paper, we present a self-training-based framework for glaucoma grading using OCT B-scans under the presence of domain shift. Particularly, the proposed two-step learning methodology resorts to pseudo-labels generated during the…

Computer Vision and Pattern Recognition · Computer Science 2021-11-24 Gabriel García , Adrián Colomer , Rafael Verdú-Monedero , José Dolz , Valery Naranjo

Glaucoma is a major eye disease, leading to vision loss in the absence of proper medical treatment. Current diagnosis of glaucoma is performed by ophthalmologists who are often analyzing several types of medical images generated by…

Computer Vision and Pattern Recognition · Computer Science 2019-04-05 Mijung Kim , Olivier Janssens , Ho-min Park , Jasper Zuallaert , Sofie Van Hoecke , Wesley De Neve