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Covariate adjustment is an approach to improve the precision of trial analyses by adjusting for baseline variables that are prognostic of the primary endpoint. Motivated by the SEARCH Universal HIV Test-and-Treat Trial (2013-2017), we tell…

Methodology · Statistics 2025-12-16 Laura B. Balzer , Mark J. van der Laan , Maya L. Petersen

Cholera, an acute diarrheal disease, is a serious concern in developing and underdeveloped areas. A qualitative understanding of cholera epidemics aims to foresee transmission patterns based on reported data and mechanistic models. The…

Quantitative Methods · Quantitative Biology 2025-03-25 Adrita Ghosh , Parthasakha Das , Tanujit Chakraborty , Pritha Das , Dibakar Ghosh

Discovering a unique causal structure is difficult due to both inherent identifiability issues, and the consequences of finite data. As such, uncertainty over causal structures, such as those obtained from a Bayesian posterior, are often…

Machine Learning · Computer Science 2025-03-06 Anish Dhir , Matthew Ashman , James Requeima , Mark van der Wilk

Multi-view unsupervised feature selection (MUFS) has recently received increasing attention for its promising ability in dimensionality reduction on multi-view unlabeled data. Existing MUFS methods typically select discriminative features…

Machine Learning · Computer Science 2025-11-19 Zongxin Shen , Yanyong Huang , Bin Wang , Jinyuan Chang , Shiyu Liu , Tianrui Li

Viral deep-sequencing data play a crucial role toward understanding disease transmission network flows, because the higher resolution of these data compared to standard Sanger sequencing provide evidence into the direction of infectious…

Methodology · Statistics 2023-02-23 Fan Bu , Joseph Kagaayi , Kate Grabowski , Oliver Ratmann , Jason Xu

We study the dynamics of cause--specific mortality rates among countries by considering them as compositions of functions. We develop a novel framework for such data structure, with particular attention to functional PCA. The application of…

Methodology · Statistics 2020-08-03 Marco Stefanucci , Stefano Mazzuco

Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care. This paper provides a practical review and tutorial on scalable…

Machine Learning · Computer Science 2023-01-20 Pulakesh Upadhyaya , Kai Zhang , Can Li , Xiaoqian Jiang , Yejin Kim

Area-specific causal inference is important in many policy and survey applications, where the goal is to evaluate treatment effects for small geographic or demographic domains. Existing causal small area estimation methods, however,…

Statistics Theory · Mathematics 2026-05-06 Tsubasa Ito , Shonosuke Sugasawa

Reports from the Health Department in the Philippines show that cases of Human Immunodeficiency Virus (HIV) are increasing despite management and control efforts by the government. Worldwide, the Philippines has one of the fastest growing…

Applications · Statistics 2019-11-14 Analaine May A. Tatoy , Roel F. Ceballos

This paper proposes the use of causal modeling to detect and mitigate algorithmic bias. We provide a brief description of causal modeling and a general overview of our approach. We then use the Adult dataset, which is available for download…

Machine Learning · Computer Science 2023-11-10 Wendy Hui , Wai Kwong Lau

In the era of big data, there is an increasing need for healthcare providers, communities, and researchers to share data and collaborate to improve health outcomes, generate valuable insights, and advance research. The Health Insurance…

Cryptography and Security · Computer Science 2023-05-23 Kai Zhang , Xiaoqian Jiang

One of the cornerstones in combating the HIV pandemic is being able to assess the current state and evolution of local HIV epidemics. This remains a complex problem, as many HIV infected individuals remain unaware of their infection status,…

Populations and Evolution · Quantitative Biology 2019-10-24 Pieter Libin , Nassim Versbraegen , Ana B. Abecasis , Perpetua Gomes , Tom Lenaerts , Ann Nowé

We empirically demonstrate that graphical models can be a valuable tool in the identification of mediating variables in causal pathways. We make use of graphical models to elucidate the causal pathway through which the treatment influences…

Applications · Statistics 2019-07-11 Adrian Dobra , Katherine Buhikire , Joachim G. Voss

Methods of causal discovery aim to identify causal structures in a data driven way. Existing algorithms are known to be unstable and sensitive to statistical errors, and are therefore rarely used with biomedical or epidemiological data. We…

Methodology · Statistics 2024-07-01 Christine W Bang , Janine Witte , Ronja Foraita , Vanessa Didelez

Modern disease mapping draws upon a wealth of high resolution spatial data products reflecting environmental and/or socioeconomic factors as covariates, or `features', within a geostatistical framework to improve predictions of disease…

Applications · Statistics 2021-03-16 Rohan Arambepola , Peter Gething , Ewan Cameron

Current Reinforcement Learning (RL) methods often suffer from sample-inefficiency, resulting from blind exploration strategies that neglect causal relationships among states, actions, and rewards. Although recent causal approaches aim to…

Artificial Intelligence · Computer Science 2025-02-17 Hongye Cao , Fan Feng , Tianpei Yang , Jing Huo , Yang Gao

Perinatal epidemiology often aims to evaluate exposures on infant outcomes. When the exposure affects the composition of people who give birth to live infants (e.g., by affecting fertility, behavior, or birth outcomes), this "live birth…

Methodology · Statistics 2024-01-23 Shalika Gupta , Laura B. Balzer , Moses R. Kamya , Diane V. Havlir , Maya L. Petersen

Men who have sex with men (MSM) remain disproportionately affected by HIV, yet optimizing Pre-exposure Prophylaxis (PrEP) distribution remains a public health challenge. Current guidelines and most modelling studies do not incorporate…

Physics and Society · Physics 2026-03-17 João Brázia , István Z. Kiss , Alexandre P. Francisco , Andreia Sofia Teixeira

Molecular HIV Surveillance (MHS) has been described as key to enabling rapid responses to HIV outbreaks. It operates by linking individuals with genetically similar viral sequences, which forms a network. A major limitation of MHS is that…

Applications · Statistics 2024-07-24 Ravi Goyal , Kevin Nguyen , Victor De Gruttola , Susan J Little , Colby Cohen , Natasha K Martin

Network surveys of key populations at risk for HIV are an essential part of the effort to understand how the epidemic spreads and how it can be prevented. Estimation of population values from the sample data has been probematical, however,…

Applications · Statistics 2019-09-12 Steve Thompson