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This paper presents a framework for incentivising colorectal cancer (CRC) screening programs from the perspective of policymakers and under the assumption that the citizens participating in the program have misaligned objectives. To do so,…

Applications · Statistics 2025-09-08 Daniel Corrales , David Rios Insua

The micro-randomized trial (MRT) is a sequential randomized experimental design to empirically evaluate the effectiveness of mobile health (mHealth) intervention components that may be delivered at hundreds or thousands of decision points.…

Methodology · Statistics 2021-12-14 Jieru Shi , Zhenke Wu , Walter Dempsey

Incentive design constitutes a foundational paradigm for influencing the behavior of strategic agents, wherein a system planner (principal) publicly commits to an incentive mechanism designed to align individual objectives with collective…

Optimization and Control · Mathematics 2026-04-08 Georgios Vasileiou , Lantian Zhang , Silun Zhang

In the early stages of human life, babies develop their skills by exploring different scenarios motivated by their inherent satisfaction rather than by extrinsic rewards from the environment. This behavior, referred to as intrinsic…

Machine Learning · Computer Science 2022-02-25 Alain Andres , Esther Villar-Rodriguez , Javier Del Ser

Solving tasks with sparse rewards is one of the most important challenges in reinforcement learning. In the single-agent setting, this challenge is addressed by introducing intrinsic rewards that motivate agents to explore unseen regions of…

Machine Learning · Computer Science 2021-05-25 Shariq Iqbal , Fei Sha

The randomized controlled trial (RCT) is the gold standard for estimating the average treatment effect (ATE) of a medical intervention but requires 100s-1000s of subjects, making it expensive and difficult to implement. While a cross-over…

Signal Processing · Electrical Eng. & Systems 2023-05-10 Sayeri Lala , Niraj K. Jha

Autonomous agents (robots) face tremendous challenges while interacting with heterogeneous human agents in close proximity. One of these challenges is that the autonomous agent does not have an accurate model tailored to the specific human…

Robotics · Computer Science 2023-04-25 Shuangge Wang , Yiwei Lyu , John M. Dolan

We study the mechanism design problem in the setting where agents are rewarded using information only. This problem is motivated by the increasing interest in secure multiparty computation techniques. More specifically, we consider the…

Computer Science and Game Theory · Computer Science 2018-09-28 Simina Brânzei , Claudio Orlandi , Guang Yang

Actor-critic methods, a type of model-free Reinforcement Learning, have been successfully applied to challenging tasks in continuous control, often achieving state-of-the art performance. However, wide-scale adoption of these methods in…

Machine Learning · Statistics 2019-10-29 Kamil Ciosek , Quan Vuong , Robert Loftin , Katja Hofmann

Randomized controlled trials are not only the golden standard in medicine and vaccine trials but have spread to many other disciplines like behavioral economics, making it an important interdisciplinary tool for scientists. When designing…

Methodology · Statistics 2021-11-30 Tassilo Schwarz

Disruptions in clinical trials may be due to external events like pandemics, warfare, and natural disasters. Resulting complications may lead to unforeseen intercurrent events (events that occur after treatment initiation and affect the…

Applications · Statistics 2024-08-20 Rachael V. Phillips , Mark J. van der Laan

Recommender systems play a crucial role in internet economies by connecting users with relevant products. However, designing effective recommender systems faces the key challenges: the exploration-exploitation tradeoff in securing incentive…

Information Retrieval · Computer Science 2026-05-26 Yuantong Li , Guang Cheng , Xiaowu Dai

Randomized controlled trials (RCTs) often exhibit limited inferential efficiency in estimating treatment effects due to small sample sizes. In recent years, the combination of external controls has gained increasing attention as a means of…

Methodology · Statistics 2025-10-06 Qinwei Yang , Jingyi Li , Peng Wu

LLM agents are deployed in environments where they must interact to acquire information. In these scenarios, the agent must reason about inherent cost-uncertainty tradeoffs in how to act, such as when to stop exploring and commit to an…

Computation and Language · Computer Science 2026-05-19 Wenxuan Ding , Nicholas Tomlin , Greg Durrett

The Exploration-Exploitation tradeoff arises in Reinforcement Learning when one cannot tell if a policy is optimal. Then, there is a constant need to explore new actions instead of exploiting past experience. In practice, it is common to…

Machine Learning · Computer Science 2019-09-10 Lior Shani , Yonathan Efroni , Shie Mannor

Unlike reinforcement learning (RL) agents, humans remain capable multitaskers in changing environments. In spite of only experiencing the world through their own observations and interactions, people know how to balance focusing on tasks…

Artificial Intelligence · Computer Science 2024-07-02 Rishav Bhagat , Jonathan Balloch , Zhiyu Lin , Julia Kim , Mark Riedl

Scientific research requires taking risks, as the most cautious approaches are unlikely to lead to the most rapid progress. Yet much funded scientific research plays it safe and funding agencies bemoan the difficulty of attracting…

Physics and Society · Physics 2024-02-28 Kevin Gross , Carl T. Bergstrom

The exploration-exploitation trade-off is central to the description of adaptive behaviour in fields ranging from machine learning, to biology, to economics. While many approaches have been taken, one approach to solving this trade-off has…

Machine Learning · Computer Science 2021-11-29 Beren Millidge , Anil Seth , Christopher Buckley

Objective: To compare different risk-based methods for optimal prediction of treatment effects. Methods: We simulated RCT data using diverse assumptions for the average treatment effect, a baseline prognostic index of risk (PI), the shape…

Health economic evaluations face the issues of non-compliance and missing data. Here, non-compliance is defined as non-adherence to a specific treatment, and occurs within randomised controlled trials (RCTs) when participants depart from…

Applications · Statistics 2019-02-26 Karla DiazOrdaz , Richard Grieve
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