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Many complex systems in science and engineering are modeled as networks whose nodes and links depict the temporal evolution of each system unit and the dynamic interaction between pairs of units, which are assessed respectively using…

Several data-driven approaches based on information theory have been proposed for analyzing high-order interactions involving three or more components of a network system. Most of these methods are defined only in the time domain and rely…

Applications · Statistics 2025-03-18 Yuri Antonacci , Chiara Bara' , Laura Sparacino , Gorana Mijatovic , Ludovico Minati , Luca Faes

The network representation is becoming increasingly popular for the description of cardiovascular interactions based on the analysis of multiple simultaneously collected variables. However, the traditional methods to assess network links…

Recent advances in signal processing and information theory are boosting the development of new approaches for the data-driven modelling of complex network systems. In the fields of Network Physiology and Network Neuroscience where the…

Methodology · Statistics 2024-01-23 Laura Sparacino , Yuri Antonacci , Gorana Mijatovic , Luca Faes

Resting-state functional magnetic resonance imaging (fMRI) has emerged as a cornerstone for psychiatric diagnosis, yet most approaches rely on pairwise brain cortical or sub-cortical connectivities that overlooks higher-order interactions…

Machine Learning · Computer Science 2026-04-21 Kunyu Zhang , Qiang Li , Vince D. Calhoun , Shujian Yu

Accurately characterizing higher-order interactions of brain regions and extracting interpretable organizational patterns from Functional Magnetic Resonance Imaging data is crucial for brain disease diagnosis. Current graph-based deep…

Neurons and Cognition · Quantitative Biology 2026-03-16 Dengyi Zhao , Zhiheng Zhou , Guiying Yan , Dongxiao Yu , Xingqin Qi

Assessing the synergistic high-order behaviors (HOBs) that emerge from underlying structural mechanisms is crucial to characterize complex systems. This work leverages the combined use of predictability and information measures to detect…

Quantitative Methods · Quantitative Biology 2025-12-16 Chiara Barà , Yuri Antonacci , Laura Sparacino , Helder Pinto , Michal Javorka , Sebastiano Stramaglia , Luca Faes

Brain connectomics is still largely dominated by pairwise-based models, such as graphs, which cannot represent circulatory or higher-order functional interactions. In this paper, we propose a multimodal framework based on Topological Signal…

Neurons and Cognition · Quantitative Biology 2026-04-01 Breno C. Bispo , Stefania Sardellitti , Juliano B. Lima , Fernando A. N. Santos

Most nervous systems encode information about stimuli in the responding activity of large neuronal networks. This activity often manifests itself as dynamically coordinated sequences of action potentials. Since multiple electrode recordings…

Neurons and Cognition · Quantitative Biology 2011-11-09 Kristina Lisa Klinkner , Cosma Rohilla Shalizi , Marcelo F. Camperi

One of the most well-established tools for modeling the brain as a complex system is the functional connectivity network, which examines the correlations between pairs of interacting brain regions. While powerful, the network model is…

Information Theory · Computer Science 2022-06-15 Thomas F. Varley , Maria Pope , Joshua Faskowitz , Olaf Sporns

With the surge in IoT devices ranging from wearables to smart homes, prompt transmission is crucial. The Age of Information (AoI) emerges as a critical metric in this context, representing the freshness of the information transmitted across…

Computers and Society · Computer Science 2025-05-06 Aymen Hamrouni , Sofie Pollin , Hazem Sallouha

Functional brain network properties are heavily influenced by how the the network nodes are defined. A common approach uses Regions of Interest (ROIs), i.e., predetermined collections of functional magnetic resonance imaging (fMRI)…

Neurons and Cognition · Quantitative Biology 2025-03-07 Tarmo Nurmi , Pietro De Luca , Maria Hakonen , Mikko Kivelä , Onerva Korhonen

Traditional functional connectivity based on functional magnetic resonance imaging (fMRI) can only capture pairwise interactions between brain regions. Hypergraphs, which reveal high-order relationships among multiple brain regions, have…

Neurons and Cognition · Quantitative Biology 2025-05-20 Wenqi Hu , Xuerui Su , Guanliang Li , Yidi Pan , Aijing Lin

High-order, beyond-pairwise interdependencies are at the core of biological, economic, and social complex systems, and their adequate analysis is paramount to understand, engineer, and control such systems. This paper presents a framework…

Data Analysis, Statistics and Probability · Physics 2022-06-06 Tomas Scagliarini , Daniele Marinazzo , Yike Guo , Sebastiano Stramaglia , Fernando E. Rosas

Cross-frequency interactions are fundamental brain mechanisms for integrating information across temporal scales. However, accurate identification of these couplings is hindered by complex multi-frequency nonlinearities and by spurious,…

Neurons and Cognition · Quantitative Biology 2026-05-07 Alessio Basti , Rikkert Hindriks , Ruggero Freddi , Gian Luca Romani , Vittorio Pizzella , Guido Nolte , Laura Marzetti

Time series analysis has proven to be a powerful method to characterize several phenomena in biology, neuroscience and economics, and to understand some of their underlying dynamical features. Despite a plethora of methods have been…

Physics and Society · Physics 2023-03-01 Andrea Santoro , Federico Battiston , Giovanni Petri , Enrico Amico

Age of information (AoI) measures information freshness at the receiver. AoI may provide insights into quality of service in communication systems. For this reason, it has been used as a cross-layer metric for wireless communication…

Systems and Control · Electrical Eng. & Systems 2020-05-06 Onur Ayan , H. Murat Gürsu , Sandra Hirche , Wolfgang Kellerer

Modeling higher-order interactions (HOI) has emerged as a crucial challenge in complex systems analysis, as many phenomena cannot be fully captured by pairwise relationships alone. Hypergraphs, which generalize graphs by allowing…

Applications · Statistics 2026-03-31 Catherine Matias

Dynamic systems that consist of a set of interacting elements can be abstracted as temporal networks. Recently, higher-order patterns that involve multiple interacting nodes have been found crucial to indicate domain-specific laws of…

Social and Information Networks · Computer Science 2022-01-19 Yunyu Liu , Jianzhu Ma , Pan Li

We address the problem of efficiently and informatively quantifying how multiplets of variables carry information about the future of the dynamical system they belong to. In particular we want to identify groups of variables carrying…

Neurons and Cognition · Quantitative Biology 2020-08-03 Sebastiano Stramaglia , Tomas Scagliarini , Bryan C. Daniels , Daniele Marinazzo
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