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Symbolic regression is the task of identifying a mathematical expression that best fits a provided dataset of input and output values. Due to the richness of the space of mathematical expressions, symbolic regression is generally a…

Machine Learning · Computer Science 2021-06-29 Mojtaba Valipour , Bowen You , Maysum Panju , Ali Ghodsi

A key challenge in reinforcement learning (RL) is managing the exploration-exploitation trade-off without sacrificing sample efficiency. Policy gradient (PG) methods excel in exploitation through fine-grained, gradient-based optimization…

Machine Learning · Computer Science 2025-04-18 Zelal Su "Lain" Mustafaoglu , Keshav Pingali , Risto Miikkulainen

Several types of numerical and combinatorial optimization algorithms have been used as useful tools to minimize functional forms. Generally, when those forms are non-linear or occur in problems without a specific optimization method,…

Chemical Physics · Physics 2007-05-23 Luiz Fernando Roncaratti , Ricardo Gargano , Geraldo Magela e Silva

Poetry is an expressive form of art that invites multiple interpretations, as readers often bring their own emotions, experiences, and cultural backgrounds into their understanding of a poem. Recognizing this, we aim to generate images for…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Sofia Jamil , Kotla Sai Charan , Sriparna Saha , Koustava Goswami , K J Joseph

Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have…

Quantitative Methods · Quantitative Biology 2024-01-29 Dexiong Chen , Philip Hartout , Paolo Pellizzoni , Carlos Oliver , Karsten Borgwardt

Transfer learning has emerged as a powerful technique in many application problems, such as computer vision and natural language processing. However, this technique is largely ignored in application to genetic data analysis. In this paper,…

Applications · Statistics 2022-06-22 Jinghang Lin , Shan Zhang , Qing Lu

Building models of human decision-making from observed behaviour is critical to better understand, diagnose and support real-world policies such as clinical care. As established policy learning approaches remain focused on imitation…

Machine Learning · Computer Science 2022-10-03 Alizée Pace , Alex J. Chan , Mihaela van der Schaar

Population-based evolutionary algorithms have great potential to handle multiobjective optimisation problems. However, these algorithms depends largely on problem characteristics, and there is a need to improve their performance for a wider…

Neural and Evolutionary Computing · Computer Science 2019-10-17 Shouyong Jiang , Hongru Li , Jinglei Guo , Mingjun Zhong , Shengxiang Yang , Marcus Kaiser , Natalio Krasnogor

Learning effective numerical representations, or embeddings, of programs is a fundamental prerequisite for applying machine learning to automate and enhance compiler optimization. Prevailing paradigms, however, present a dilemma. Static…

Machine Learning · Computer Science 2025-10-16 Haolin Pan , Jinyuan Dong , Hongbin Zhang , Hongyu Lin , Mingjie Xing , Yanjun Wu

Gene expression datasets offer insights into gene regulation mechanisms, biochemical pathways, and cellular functions. Additionally, comparing gene expression profiles between disease and control patients can deepen the understanding of…

Machine Learning · Computer Science 2025-03-27 Rita T. Sousa , Heiko Paulheim

Designing protein sequences that fold into a target 3D structure, known as protein inverse folding, is a fundamental challenge in protein engineering. While recent deep learning methods have achieved impressive performance by recovering…

Biomolecules · Quantitative Biology 2025-06-03 Mengdi Liu , Xiaoxue Cheng , Zhangyang Gao , Hong Chang , Cheng Tan , Shiguang Shan , Xilin Chen

Mathematical formulas serve as a language through which humans communicate with nature. Discovering mathematical laws from scientific data to describe natural phenomena has been a long-standing pursuit of humanity for centuries. In the…

Artificial Intelligence · Computer Science 2026-05-14 Yanjie Li , Liping Zhang , Min Wu , Weijun Li , Lina Yu , Jingyi Liu , Yusong Deng , Mingzhu Wan , Xin Ning

Text-to-image generation has progressed rapidly, but faithfully generating complex scenes requires extensive trial-and-error to find the exact prompt. In the prompt inversion task, the goal is to recover a textual prompt that can faithfully…

Machine Learning · Computer Science 2026-04-30 Asaf Buchnick , Aviv Shamsian , Aviv Navon , Ethan Fetaya

Searches for Beyond the Standard Model physics require probing the Standard Model with increased precision. One way this can be achieved is by improving the accuracy of the event selection classifiers. Recently, Gene Expression Programming…

High Energy Physics - Experiment · Physics 2024-09-23 Andris Potrebko , Inese Poļaka

Background: Coevolution within a protein family is often predicted using statistics that measure the degree of covariation between positions in the protein sequence. Mutual Information is a measure of dependence between two random variables…

Populations and Evolution · Quantitative Biology 2013-04-17 Russell J. Dickson , Gregory B. Gloor

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet,…

Quantitative Methods · Quantitative Biology 2023-04-10 Mingchen Li , Liqi Kang , Yi Xiong , Yu Guang Wang , Guisheng Fan , Pan Tan , Liang Hong

The protein-protein interactions (PPIs) are crucial for understanding the majority of cellular processes. PPIs play important role in gene transcription regulation, cellular signaling, molecular basis of immune response and more. Moreover,…

Biomolecules · Quantitative Biology 2016-05-31 Maciej Pawel Ciemny , Mateusz Kurcinski , Andrzej Kolinski , Sebastian Kmiecik

Several mating restriction techniques have been implemented in Evolutionary Algorithms to promote diversity. From similarity-based selection to niche preservation, the general goal is to avoid premature convergence by not having fitness…

Neural and Evolutionary Computing · Computer Science 2025-04-09 José Maria Simões , Nuno Lourenço , Penousal Machado

We present a framework for optimizing prompts in vision-language models to elicit multimodal reasoning without model retraining. Using an evolutionary algorithm to guide prompt updates downstream of visual tasks, our approach improves upon…

Computation and Language · Computer Science 2025-04-01 Sid Bharthulwar , John Rho , Katrina Brown

The rise of deep learning has marked significant progress in fields such as computer vision, natural language processing, and medical imaging, primarily through the adaptation of pre-trained models for specific tasks. Traditional…

Machine Learning · Computer Science 2024-04-25 Charith Chandra Sai Balne , Sreyoshi Bhaduri , Tamoghna Roy , Vinija Jain , Aman Chadha