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Creating open-ended algorithms, which generate their own never-ending stream of novel and appropriately challenging learning opportunities, could help to automate and accelerate progress in machine learning. A recent step in this direction…

Neural and Evolutionary Computing · Computer Science 2020-04-14 Rui Wang , Joel Lehman , Aditya Rawal , Jiale Zhi , Yulun Li , Jeff Clune , Kenneth O. Stanley

Here we propose an evolutionary algorithm that self modifies its operators at the same time that candidate solutions are evolved. This tackles convergence and lack of diversity issues, leading to better solutions. Operators are represented…

Neural and Evolutionary Computing · Computer Science 2017-12-19 Andres Felipe Cruz Salinas , Jonatan Gomez Perdomo

The discovery of equations with knowledge of the process origin is a tempting prospect. However, most equation discovery tools rely on gradient methods, which offer limited control over parameters. An alternative approach is the…

Neural and Evolutionary Computing · Computer Science 2023-08-10 Elizaveta Ivanchik , Alexander Hvatov

Neuro-encoded expression programming(NEEP) that aims to offer a novel continuous representation of combinatorial encoding for genetic programming methods is proposed in this paper. Genetic programming with linear representation uses…

Neural and Evolutionary Computing · Computer Science 2021-04-12 Aftab Anjum , Fengyang Sun , Lin Wang , Jeff Orchard

Enzyme engineering enables the modification of wild-type proteins to meet industrial and research demands by enhancing catalytic activity, stability, binding affinities, and other properties. The emergence of deep learning methods for…

Computation and Language · Computer Science 2024-10-29 Yang Tan , Ruilin Wang , Banghao Wu , Liang Hong , Bingxin Zhou

While the history of machine learning so far largely encompasses a series of problems posed by researchers and algorithms that learn their solutions, an important question is whether the problems themselves can be generated by the algorithm…

Neural and Evolutionary Computing · Computer Science 2019-02-22 Rui Wang , Joel Lehman , Jeff Clune , Kenneth O. Stanley

Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the…

Biomolecules · Quantitative Biology 2019-04-23 Kevin K. Yang , Zachary Wu , Frances H. Arnold

Estimating the effort of software systems is an essential topic in software engineering, carrying out an estimation process reliably and accurately for a software forms a vital part of the software development phases. Many researchers have…

Software Engineering · Computer Science 2018-05-03 Najla Akram , AL-Saati , Taghreed Riyadh Alreffaee

As extended reality (XR) is redefining how users interact with computing devices, research in human action recognition is gaining prominence. Typically, models deployed on immersive computing devices are static and limited to their default…

Computer Vision and Pattern Recognition · Computer Science 2025-04-28 Prachi Garg , Joseph K J , Vineeth N Balasubramanian , Necati Cihan Camgoz , Chengde Wan , Kenrick Kin , Weiguang Si , Shugao Ma , Fernando De La Torre

To reduce experimental effort associated with directed protein evolution and to explore the sequence space encoded by mutating multiple positions simultaneously, we incorporate machine learning in the directed evolution workflow.…

Biomolecules · Quantitative Biology 2020-01-07 Zachary Wu , S. B. Jennifer Kan , Russell D. Lewis , Bruce J. Wittmann , Frances H. Arnold

With the demand for machine learning increasing, so does the demand for tools which make it easier to use. Automated machine learning (AutoML) tools have been developed to address this need, such as the Tree-Based Pipeline Optimization Tool…

Neural and Evolutionary Computing · Computer Science 2018-03-13 Pieter Gijsbers , Joaquin Vanschoren , Randal S. Olson

Enzyme is the major workhorse to carry out the diverse cellular functions. It catalyzes the biological reactions with a high specificity, with its topology playing a crucial role. For ecologically safe production of numerous bioproducts…

Biomolecules · Quantitative Biology 2021-06-04 Prabha Sankara Narayanan , Ashish Runthala

Protein evolution through amino acid mutations is a cornerstone of life sciences. Recent advances in protein language models have shown rich evolutionary patterns, offering unprecedented potential for in-silicon directed evolution. However,…

Artificial Intelligence · Computer Science 2026-01-08 Yaodong Yang , Yang Wang , Jinpeng Li , Pei Guo , Da Han , Guangyong Chen , Pheng-Ann Heng

Machine translation (MT) has historically faced significant challenges when applied to literary works, particularly in the domain of poetry translation. The advent of Large Language Models such as ChatGPT holds potential for innovation in…

Computation and Language · Computer Science 2024-06-06 Shanshan Wang , Derek F. Wong , Jingming Yao , Lidia S. Chao

How to automatically design better machine learning programs is an open problem within AutoML. While evolution has been a popular tool to search for better ML programs, using learning itself to guide the search has been less successful and…

Machine Learning · Computer Science 2024-02-09 John D. Co-Reyes , Yingjie Miao , George Tucker , Aleksandra Faust , Esteban Real

Choosing the most adequate kernel is crucial in many Machine Learning applications. Gaussian Process is a state-of-the-art technique for regression and classification that heavily relies on a kernel function. However, in the Gaussian…

Machine Learning · Computer Science 2019-10-15 Ibai Roman , Roberto Santana , Alexander Mendiburu , Jose A. Lozano

Proteins are responsible for the most diverse set of functions in biology. The ability to extract information from protein sequences and to predict the effects of mutations is extremely valuable in many domains of biology and medicine.…

Quantitative Methods · Quantitative Biology 2018-01-04 Sam Sinai , Eric Kelsic , George M. Church , Martin A. Nowak

Genetic Programming (GP) is an evolutionary algorithm commonly used for machine learning tasks. In this paper we present a method that allows GP to transform the representation of a large-scale machine learning dataset into a more compact…

Neural and Evolutionary Computing · Computer Science 2018-02-21 Lino Rodriguez-Coayahuitl , Alicia Morales-Reyes , Hugo Jair Escalante

The automatic generation of computer programs is one of the main applications with practical relevance in the field of evolutionary computation. With program synthesis techniques not only software developers could be supported in their…

Neural and Evolutionary Computing · Computer Science 2021-08-30 Dominik Sobania , Dirk Schweim , Franz Rothlauf

Optimal path planning involves finding a feasible state sequence between a start and a goal that optimizes an objective. This process relies on heuristic functions to guide the search direction. While a robust function can improve search…

Robotics · Computer Science 2025-08-29 Liding Zhang , Kuanqi Cai , Zhenshan Bing , Chaoqun Wang , Alois Knoll