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Electrocardiogram is a useful diagnostic signal that can detect cardiac abnormalities by measuring the electrical activity generated by the heart. Due to its rapid, non-invasive, and richly informative characteristics, ECG has many emerging…

Machine Learning · Computer Science 2025-12-09 Hanhui Deng , Xinglin Li , Jie Luo , Di Wu

Accurate click-through rate (CTR) prediction is vital for online advertising and recommendation systems. Recent deep learning advancements have improved the ability to capture feature interactions and understand user interests. However,…

Information Retrieval · Computer Science 2025-02-24 Kefan Wang , Hao Wang , Kenan Song , Wei Guo , Kai Cheng , Zhi Li , Yong Liu , Defu Lian , Enhong Chen

Enzyme sequences and structures are routinely used in the biological sciences as queries to search for functionally related enzymes in online databases. To this end, one usually departs from some notion of similarity, comparing two enzymes…

Protein contacts contain important information for protein structure and functional study, but contact prediction from sequence information remains very challenging. Recently evolutionary coupling (EC) analysis, which predicts contacts by…

Quantitative Methods · Quantitative Biology 2015-12-01 Siqi Sun , Jianzhu Ma , Sheng Wang , Jinbo Xu

The affinity and specificity of protein-molecule binding directly impact functional outcomes, uncovering the mechanisms underlying biological regulation and signal transduction. Most deep-learning-based prediction approaches focus on…

Machine Learning · Computer Science 2025-06-03 Haitao Lin , Odin Zhang , Jia Xu , Yunfan Liu , Zheng Cheng , Lirong Wu , Yufei Huang , Zhifeng Gao , Stan Z. Li

In recent era prediction of enzyme class from an unknown protein is one of the challenging tasks in bioinformatics. Day to day the number of proteins is increases as result the prediction of enzyme class gives a new opportunity to…

Machine Learning · Computer Science 2019-01-21 Chhote Lal Prasad Gupta , Anand Bihari , Sudhakar Tripathi

Discovering the intended items of user queries from a massive repository of items is one of the main goals of an e-commerce search system. Relevance prediction is essential to the search system since it helps improve performance. When…

Information Retrieval · Computer Science 2023-07-21 Jiong Cai , Yong Jiang , Yue Zhang , Chengyue Jiang , Ke Yu , Jianhui Ji , Rong Xiao , Haihong Tang , Tao Wang , Zhongqiang Huang , Pengjun Xie , Fei Huang , Kewei Tu

Endocrine-disrupting chemicals (EDCs) threaten human health, ecosystems, and biodiversity by interfering with hormonal signaling pathways conserved across vertebrates. Traditional in vivo assays are costly and time-consuming, limiting their…

Proteins perform critical processes in all living systems: converting solar energy into chemical energy, replicating DNA, as the basis of highly performant materials, sensing and much more. While an incredible range of functionality has…

Biomolecules · Quantitative Biology 2021-09-29 Leonardo V. Castorina , Rokas Petrenas , Kartic Subr , Christopher W. Wood

Deep learning is significantly advancing the analysis of electroencephalography (EEG) data by effectively discovering highly nonlinear patterns within the signals. Data partitioning and cross-validation are crucial for assessing model…

Signal Processing · Electrical Eng. & Systems 2025-05-20 Federico Del Pup , Andrea Zanola , Louis Fabrice Tshimanga , Alessandra Bertoldo , Livio Finos , Manfredo Atzori

Predicting enzyme-substrate interactions has long been a fundamental problem in biochemistry and metabolic engineering. While existing methods could leverage databases of expert-curated enzyme-substrate pairs for models to learn from known…

Artificial Intelligence · Computer Science 2026-01-12 Tengwei Song , Long Yin , Zhen Han , Zhiqiang Xu

We demonstrate that an attention-based encoder-decoder model can be used for sentence-level grammatical error identification for the Automated Evaluation of Scientific Writing (AESW) Shared Task 2016. The attention-based encoder-decoder…

Computation and Language · Computer Science 2016-04-19 Allen Schmaltz , Yoon Kim , Alexander M. Rush , Stuart M. Shieber

Enzyme engineering enables the modification of wild-type proteins to meet industrial and research demands by enhancing catalytic activity, stability, binding affinities, and other properties. The emergence of deep learning methods for…

Computation and Language · Computer Science 2024-10-29 Yang Tan , Ruilin Wang , Banghao Wu , Liang Hong , Bingxin Zhou

EEG decoding systems based on deep neural networks have been widely used in decision making of brain computer interfaces (BCI). Their predictions, however, can be unreliable given the significant variance and noise in EEG signals. Previous…

Signal Processing · Electrical Eng. & Systems 2022-10-04 Tiehang Duan , Zhenyi Wang , Sheng Liu , Sargur N. Srihari , Hui Yang

The high efficiency video coding (HEVC) standard and the joint exploration model (JEM) codec incorporate 35 and 67 intra prediction modes (IPMs) respectively, which are essential for efficient compression of Intra coded blocks. These IPMs…

Image and Video Processing · Electrical Eng. & Systems 2023-10-10 Kevin Reuzé , Wassim Hamidouche , Pierrick Philippe , Olivier Déforges

Predicting gene function from its DNA sequence is a fundamental challenge in biology. Many deep learning models have been proposed to embed DNA sequences and predict their enzymatic function, leveraging information in public databases…

Enzyme is the major workhorse to carry out the diverse cellular functions. It catalyzes the biological reactions with a high specificity, with its topology playing a crucial role. For ecologically safe production of numerous bioproducts…

Biomolecules · Quantitative Biology 2021-06-04 Prabha Sankara Narayanan , Ashish Runthala

Enzyme mining is rapidly evolving as a data-driven strategy to identify biocatalysts with tailored functions from the vast landscape of uncharacterized proteins. The integration of machine learning into these workflows enables…

Biomolecules · Quantitative Biology 2025-07-11 Yanzi Zhang , Felix Moorhoff , Sizhe Qiu , Wenjuan Dong , David Medina-Ortiz , Jing Zhao , Mehdi D. Davari

The dichotomy between the challenging nature of obtaining annotations for activities, and the more straightforward nature of data collection from wearables, has resulted in significant interest in the development of techniques that utilize…

Machine Learning · Computer Science 2022-11-14 Harish Haresamudram , Irfan Essa , Thomas Ploetz

The adoption of deep learning-based healthcare decision support systems such as the detection of irregular cardiac rhythm is hindered by challenges such as lack of access to quality data and the high costs associated with the collection and…

Machine Learning · Computer Science 2022-05-31 Sagnik Dakshit , Barbara Mukami Maweu , Sristi Dakshit , Balakrishnan Prabhakaran