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Protein-protein interactions (PPIs) are essentials for many biological processes where two or more proteins physically bind together to achieve their functions. Modeling PPIs is useful for many biomedical applications, such as vaccine…

Biomolecules · Quantitative Biology 2021-12-10 Yang Xue , Zijing Liu , Xiaomin Fang , Fan Wang

Prompt Learning has recently gained great popularity in bridging the gap between pretraining tasks and various downstream tasks. It freezes Pretrained Language Models (PLMs) and only tunes a few task-related parameters (prompts) for…

Computation and Language · Computer Science 2022-06-07 Yuezihan Jiang , Hao Yang , Junyang Lin , Hanyu Zhao , An Yang , Chang Zhou , Hongxia Yang , Zhi Yang , Bin Cui

Incremental Learning (IL) aims to learn deep models on sequential tasks continually, where each new task includes a batch of new classes and deep models have no access to task-ID information at the inference time. Recent vast pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Qian Feng , Hanbin Zhao , Chao Zhang , Jiahua Dong , Henghui Ding , Yu-Gang Jiang , Hui Qian

Prompt learning has emerged as an efficient alternative for fine-tuning foundational models, such as CLIP, for various downstream tasks. However, there is no work that provides a comprehensive explanation for the working mechanism of the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Shuailei Ma , Chen-Wei Xie , Ying Wei , Siyang Sun , Jiaqi Fan , Xiaoyi Bao , Yuxin Guo , Yun Zheng

While Pre-trained Language Models (PLMs) internalize a great amount of world knowledge, they have been shown incapable of recalling these knowledge to solve tasks requiring complex & multi-step reasoning. Similar to how humans develop a…

Computation and Language · Computer Science 2022-10-25 Boshi Wang , Xiang Deng , Huan Sun

Deep learning offers transformative potential in medical imaging, yet its clinical adoption is frequently hampered by challenges such as data scarcity, distribution shifts, and the need for robust task generalization. Prompt-based…

Image and Video Processing · Electrical Eng. & Systems 2025-07-03 Hao Yang , Xinlong Liang , Zhang Li , Yue Sun , Zheyu Hu , Xinghe Xie , Behdad Dashtbozorg , Jincheng Huang , Shiwei Zhu , Luyi Han , Jiong Zhang , Shanshan Wang , Ritse Mann , Qifeng Yu , Tao Tan

Pre-trained vision-language models are able to interpret visual concepts and language semantics. Prompt learning, a method of constructing prompts for text encoders or image encoders, elicits the potentials of pre-trained models and readily…

Computer Vision and Pattern Recognition · Computer Science 2025-02-21 Zhenhan Huang , Tejaswini Pedapati , Pin-Yu Chen , Jianxi Gao

Prompt engineering has emerged as an indispensable technique for extending the capabilities of large language models (LLMs) and vision-language models (VLMs). This approach leverages task-specific instructions, known as prompts, to enhance…

Artificial Intelligence · Computer Science 2025-03-18 Pranab Sahoo , Ayush Kumar Singh , Sriparna Saha , Vinija Jain , Samrat Mondal , Aman Chadha

Click-through rate (CTR) prediction has become increasingly indispensable for various Internet applications. Traditional CTR models convert the multi-field categorical data into ID features via one-hot encoding, and extract the…

Information Retrieval · Computer Science 2024-06-27 Jianghao Lin , Bo Chen , Hangyu Wang , Yunjia Xi , Yanru Qu , Xinyi Dai , Kangning Zhang , Ruiming Tang , Yong Yu , Weinan Zhang

Multi-modality pre-training paradigm that aligns protein sequences and biological descriptions has learned general protein representations and achieved promising performance in various downstream applications. However, these works were…

Machine Learning · Computer Science 2024-12-31 Hanjing Zhou , Mingze Yin , Wei Wu , Mingyang Li , Kun Fu , Jintai Chen , Jian Wu , Zheng Wang

Predicting protein-protein interactions (PPIs) by learning informative representations from amino acid sequences is a challenging yet important problem in biology. Although various deep learning models in Siamese architecture have been…

Machine Learning · Computer Science 2020-10-19 Kishan KC , Feng Cui , Anne Haake , Rui Li

Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have…

Quantitative Methods · Quantitative Biology 2024-01-29 Dexiong Chen , Philip Hartout , Paolo Pellizzoni , Carlos Oliver , Karsten Borgwardt

Prompt learning is a new learning paradigm which reformulates downstream tasks as similar pretraining tasks on pretrained models by leveraging textual prompts. Recent works have demonstrated that prompt learning is particularly useful for…

Computation and Language · Computer Science 2022-10-21 Yue Zhang , Hongliang Fei , Dingcheng Li , Tan Yu , Ping Li

The objective of this work is to explore how to effectively and efficiently adapt pre-trained visual foundation models to various downstream tasks of semantic segmentation. Previous methods usually fine-tuned the entire networks for each…

Computer Vision and Pattern Recognition · Computer Science 2022-11-22 Lingbo Liu , Jianlong Chang , Bruce X. B. Yu , Liang Lin , Qi Tian , Chang-Wen Chen

Pretrained language models (PLMs) have made remarkable progress in text generation tasks via fine-tuning. While, it is challenging to fine-tune PLMs in a data-scarce situation. Therefore, it is non-trivial to develop a general and…

Computation and Language · Computer Science 2022-05-17 Junyi Li , Tianyi Tang , Jian-Yun Nie , Ji-Rong Wen , Wayne Xin Zhao

Prompt-based learning has been demonstrated as a compelling paradigm contributing to large language models' tremendous success (LLMs). Inspired by their success in language tasks, existing research has leveraged LLMs in embodied instruction…

Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

Quantitative Methods · Quantitative Biology 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

Prompt engineering is a technique that involves augmenting a large pre-trained model with task-specific hints, known as prompts, to adapt the model to new tasks. Prompts can be created manually as natural language instructions or generated…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Jindong Gu , Zhen Han , Shuo Chen , Ahmad Beirami , Bailan He , Gengyuan Zhang , Ruotong Liao , Yao Qin , Volker Tresp , Philip Torr

Pre-trained language models (PLM) have marked a huge leap in neural dialogue modeling. While PLMs are pre-trained on large-scale text corpora, they are usually fine-tuned on scarce dialogue data with specific domain knowledge and dialogue…

Computation and Language · Computer Science 2021-12-14 Xiaodong Gu , Kang Min Yoo , Sang-Woo Lee

Prompt tuning, in which a base pretrained model is adapted to each task via conditioning on learned prompt vectors, has emerged as a promising approach for efficiently adapting large language models to multiple downstream tasks. However,…

Computation and Language · Computer Science 2023-03-07 Zhen Wang , Rameswar Panda , Leonid Karlinsky , Rogerio Feris , Huan Sun , Yoon Kim
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