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Microsatellite instability (MSI) is a tumor phenotype whose diagnosis largely impacts patient care in colorectal cancers (CRC), and is associated with response to immunotherapy in all solid tumors. Deep learning models detecting MSI tumors…

Image and Video Processing · Electrical Eng. & Systems 2022-03-23 Charlie Saillard , Olivier Dehaene , Tanguy Marchand , Olivier Moindrot , Aurélie Kamoun , Benoit Schmauch , Simon Jegou

Motivation: Microsatellite instability (MSI) is a cancer biomarker associated with cancer prognosis and chemotherapy sensitivity. Since the discovery of MSI, polymerase chain reaction (PCR)-based testing has been considered the gold…

Genomics · Quantitative Biology 2023-04-17 Ji Detao , Liu Weier

Microsatellite instability-high (MSI-H) is a tumor agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status is not routinely tested in prostate cancer, in part due to low prevalence and assay cost. As such, prediction…

Based on global genomic status, the cancer tumor is classified as Microsatellite Instable (MSI) and Microsatellite Stable (MSS). Immunotherapy is used to diagnose MSI, whereas radiation and chemotherapy are used for MSS. Therefore, it is…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Sai Venkatesh Chilukoti , Imran Hossen Md , Liqun Shan , Vijay Srinivas Tida , Xiali Hei

The accurate diagnosis and molecular profiling of colorectal cancers are critical for planning the best treatment options for patients. Microsatellite instability (MSI) or mismatch repair (MMR) status plays a vital role in appropriate…

Quantitative Methods · Quantitative Biology 2022-04-27 Ruqayya Awan , Mohammed Nimir , Shan E Ahmed Raza , Mohsin Bilal , Johannes Lotz , David Snead , Andrew Robinson , Nasir Rajpoot

Assessing microsatellite stability status of a patient's colorectal cancer is crucial in personalizing treatment regime. Recently, convolutional-neural-networks (CNN) combined with transfer-learning approaches were proposed to circumvent…

Computer Vision and Pattern Recognition · Computer Science 2022-08-23 Daniel Shats , Hadar Hezi , Guy Shani , Yosef E. Maruvka , Moti Freiman

The prediction of microsatellite instability (MSI) and microsatellite stability (MSS) is essential in predicting both the treatment response and prognosis of gastrointestinal cancer. In clinical practice, a universal MSI testing is…

Image and Video Processing · Electrical Eng. & Systems 2022-01-14 Kaifeng Pang , Zuhayr Asad , Shilin Zhao , Yuankai Huo

Microsatellite instability (MSI) is associated with several tumor types and its status has become increasingly vital in guiding patient treatment decisions. However, in clinical practice, distinguishing MSI from its counterpart is…

Machine Learning · Statistics 2020-10-08 Jin Zhu , Wangwei Wu , Yuting Zhang , Shiyun Lin , Yukang Jiang , Ruixian Liu , Xueqin Wang

We present a system for the prediction of microsatellite instability (MSI) from H&E images of colorectal cancer using deep learning (DL) techniques customized for tissue microarrays (TMAs). The system incorporates an end-to-end image…

Computer Vision and Pattern Recognition · Computer Science 2021-10-29 Aurelia Bustos , Artemio Payá , Andres Torrubia , Rodrigo Jover , Xavier Llor , Xavier Bessa , Antoni Castells , Cristina Alenda

Colorectal cancer (CRC) is among the top three malignant tumor types in terms of morbidity and mortality. Histopathological images are the gold standard for diagnosing colon cancer. Cellular nuclei instance segmentation and classification,…

Computer Vision and Pattern Recognition · Computer Science 2024-01-29 Liangrui Pan , Lian Wang , Zhichao Feng , Zhujun Xu , Liwen Xu , Shaoliang Peng

In this work, we introduce a spatially transformed DenseNet architecture for transformation invariant classification of cancer tissue. Our architecture increases the accuracy of the base DenseNet architecture while adding the ability to…

Image and Video Processing · Electrical Eng. & Systems 2022-04-26 Omar Mahdi , Ali Bou Nassif

Colorectal cancer (CRC) micro-satellite instability (MSI) prediction on histopathology images is a challenging weakly supervised learning task that involves multi-instance learning on gigapixel images. To date, radiology images have proven…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Quan Liu , Jiawen Yao , Lisha Yao , Xin Chen , Jingren Zhou , Le Lu , Ling Zhang , Zaiyi Liu , Yuankai Huo

Lung and colon cancers are predominant contributors to cancer mortality. Early and accurate diagnosis is crucial for effective treatment. By utilizing imaging technology in different image detection, learning models have shown promise in…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Diponkor Bala , S M Rakib Ul Karim , Rownak Ara Rasul

This paper presents a deep learning framework for the multi-class classification of gastrointestinal abnormalities in Video Capsule Endoscopy (VCE) frames. The aim is to automate the identification of ten GI abnormality classes, including…

Computer Vision and Pattern Recognition · Computer Science 2024-10-25 Aman Sagar , Preeti Mehta , Monika Shrivastva , Suchi Kumari

Previously, image interpretation in radiology relied heavily on manual methods. However, manual classification of brain tumor medical images is time-consuming and labor-intensive. Even with shallow convolutional neural network models, the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Yufeng Li , Wenchao Zhao , Bo Dang , Weimin Wang

Oil reheating has a significant impact on global health due to its extensive consumption, especially in South Asia, and severe health risks. Nevertheless, food image analysis using multispectral imaging systems(MISs) has not been applied to…

Image and Video Processing · Electrical Eng. & Systems 2022-02-08 D. Y. L. Ranasinghe , H. M. H. K. Weerasooriya , S. Herath , M. P. B. Ekanayake , H. M. V. R. Herath , G. M. R. I. Godaliyadda , T. Madhujith

Most existing star-galaxy classifiers depend on the reduced information from catalogs, necessitating careful data processing and feature extraction. In this study, we employ a supervised machine learning method (GoogLeNet) to automatically…

Astrophysics of Galaxies · Physics 2024-09-23 Shiliang Zhang , Guanwen Fang , Jie Song , Ran Li , Yizhou Gu , Zesen Lin , Chichun Zhou , Yao Dai , Xu Kong

The differentiation between tumor recurrence and radiation-induced contrast enhancements in post-treatment glioblastoma patients remains a major clinical challenge. Existing approaches rely on clinically sparsely available diffusion MRI or…

Accurate segmentation of gastrointestinal (GI) organs in magnetic resonance enterography (MRE) is critical for diagnosing inflammatory bowel disease (IBD). However, anatomical variability, class imbalance, and low tissue contrast hinder…

Image and Video Processing · Electrical Eng. & Systems 2026-04-21 Ashiqur Rahman , Md. Abu Sayed , Md Sharjis Ibne Wadud , Md. Abu Asad Al-Hafiz , Adam Mushtak , Muhammad E. H. Chowdhury

Gastrointestinal cancer is a leading cause of cancer-related incidence and death, making it crucial to develop novel computer-aided diagnosis systems for early detection and enhanced treatment. Traditional approaches rely on the expertise…

Image and Video Processing · Electrical Eng. & Systems 2024-08-21 Aliza Subedi , Smriti Regmi , Nisha Regmi , Bhumi Bhusal , Ulas Bagci , Debesh Jha
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